| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 9,953,313 | 9,965,862 | +12,549 | 1.46 | 2.24 | +0.77 | buy |
| Avoro Capital Advisors LLC | 0 | 6,150,000 | +6,150,000 | 0.00 | 1.06 | +1.06 | buy |
| STATE STREET CORP | 2,174,022 | 4,389,647 | +2,215,625 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,309,394 | 3,677,678 | -631,716 | 0.00 | 0.00 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 5,639,994 | 2,767,034 | -2,872,960 | 0.04 | 0.02 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 2,401,704 | 2,471,704 | +70,000 | 1.24 | 1.54 | +0.30 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,813 | 2,438,050 | +2,409,237 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,572,000 | 2,400,000 | -2,172,000 | 1.17 | 0.94 | -0.23 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 4,053,077 | 2,082,021 | -1,971,056 | 0.61 | 0.39 | -0.22 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,404,068 | 1,432,013 | +27,945 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,178,796 | 1,305,250 | +126,454 | 0.28 | 0.49 | +0.21 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,214,900 | 1,051,259 | -163,641 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,134,744 | 1,029,049 | -105,695 | 0.00 | 0.00 | +0.00 | sell |
| WASATCH ADVISORS LP | 1,297,574 | 989,579 | -307,995 | 0.07 | 0.08 | +0.01 | sell |
| NORTHERN TRUST CORP | 774,479 | 732,414 | -42,065 | 0.00 | 0.00 | +0.00 | sell |
| Vestal Point Capital, LP | 0 | 725,000 | +725,000 | 0.00 | 0.88 | +0.88 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 763,527 | 715,027 | -48,500 | 0.01 | 0.02 | +0.01 | sell |
| PINNACLE ASSOCIATES LTD | 687,980 | 647,235 | -40,745 | 0.11 | 0.15 | +0.04 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,222 | 531,922 | +451,700 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 833,500 | 522,946 | -310,554 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 450,000 | 500,000 | +50,000 | 0.63 | 0.72 | +0.10 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,258,641 | 478,079 | -780,562 | 3.73 | 1.97 | -1.76 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,057,693 | 473,413 | -584,280 | 0.04 | 0.02 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 398,944 | 463,430 | +64,486 | 0.02 | 0.04 | +0.01 | buy |
| FEDERATED HERMES, INC. | 803,375 | 453,732 | -349,643 | 0.02 | 0.02 | -0.00 | sell |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 244,196 | 418,282 | +174,086 | 0.01 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 72,839 | 378,523 | +305,684 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 611,932 | 378,327 | -233,605 | 0.13 | 0.10 | -0.03 | sell |
| Woodline Partners LP | 0 | 365,425 | +365,425 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 182,484 | 364,234 | +181,750 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 94,732 | 352,695 | +257,963 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 617,963 | 346,325 | -271,638 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 267,876 | 344,603 | +76,727 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 318,167 | +318,167 | 0.00 | 1.27 | +1.27 | buy |
| FRANKLIN RESOURCES INC | 57,847 | 315,272 | +257,425 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 142,418 | 310,900 | +168,482 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 46,471 | 305,076 | +258,605 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 0 | 295,020 | +295,020 | 0.00 | 0.29 | +0.29 | buy |
| UBS Group AG | 133,011 | 258,359 | +125,348 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 265,072 | 249,707 | -15,365 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 30,546 | 246,483 | +215,937 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 238,123 | 245,831 | +7,708 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 75,048 | 213,448 | +138,400 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 351,175 | 211,948 | -139,227 | 0.00 | 0.00 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 0 | 208,698 | +208,698 | 0.00 | 0.03 | +0.03 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 114,979 | 148,018 | +33,039 | 0.01 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 49,193 | 130,133 | +80,940 | 0.00 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,464 | 119,549 | +97,085 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 45,003 | 116,317 | +71,314 | 0.01 | 0.02 | +0.01 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 15,168 | 105,787 | +90,619 | 0.15 | 0.07 | -0.07 | buy |
| Atom Investors LP | 139,090 | 104,845 | -34,245 | 0.24 | 0.19 | -0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 97,703 | +97,703 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 90,449 | 93,099 | +2,650 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 862,965 | 92,695 | -770,270 | 0.01 | 0.00 | -0.01 | sell |
| Swiss National Bank | 0 | 91,800 | +91,800 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 132,374 | 82,030 | -50,344 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 157,531 | 81,742 | -75,789 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 58,679 | 81,185 | +22,506 | 0.01 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,400 | 78,874 | +49,474 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 87,088 | 75,505 | -11,583 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 107,600 | 67,030 | -40,570 | 0.00 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 0 | 64,007 | +64,007 | 0.00 | 0.23 | +0.23 | buy |
| AMERICAN CENTURY COMPANIES INC | 51,366 | 63,428 | +12,062 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 38,947 | 58,997 | +20,050 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 149,184 | 58,624 | -90,560 | 0.03 | 0.02 | -0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 49,337 | 57,060 | +7,723 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,424 | 54,810 | +38,386 | 0.01 | 0.03 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 33,870 | 53,620 | +19,750 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 60,329 | 53,113 | -7,216 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 9,457 | 51,781 | +42,324 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 0 | 49,307 | +49,307 | 0.00 | 0.44 | +0.44 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,017 | 47,955 | +37,938 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 47,315 | +47,315 | 0.00 | 0.01 | +0.01 | buy |
| Pennant Investors, LP | 43,800 | 43,800 | 0 | 0.13 | 0.18 | +0.05 | hold |
| ALPS ADVISORS INC | 41,674 | 43,752 | +2,078 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 165,107 | 40,340 | -124,767 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 188,332 | 39,400 | -148,932 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 67,300 | 36,900 | -30,400 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 36,775 | +36,775 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 43,279 | 36,095 | -7,184 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 42,109 | 35,313 | -6,796 | 0.00 | 0.00 | -0.00 | sell |
| Lighthouse Investment Partners, LLC | 0 | 34,211 | +34,211 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 33,750 | +33,750 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 33,403 | +33,403 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,179 | 33,179 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 10,580 | 32,548 | +21,968 | 0.00 | 0.02 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 31,663 | +31,663 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 70,977 | 31,210 | -39,767 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 30,251 | 29,993 | -258 | 0.00 | 0.00 | +0.00 | sell |
| Pathstone Holdings, LLC | 13,050 | 29,161 | +16,111 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 28,745 | +28,745 | 0.00 | 0.06 | +0.06 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 26,900 | +26,900 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 30,892 | 24,201 | -6,691 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 23,915 | +23,915 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,400 | 23,230 | -170 | 0.00 | 0.00 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 23,197 | +23,197 | 0.00 | 0.07 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,694 | 23,171 | +4,477 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 53,515 | 21,015 | -32,500 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 18,046 | 20,708 | +2,662 | 0.00 | 0.00 | +0.00 | buy |