| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 2,400,000 | 6,000,000 | +3,600,000 | 0.47 | 0.32 | -0.15 | buy |
| WASATCH ADVISORS LP | 989,579 | 2,451,797 | +1,462,218 | 0.08 | 0.06 | -0.02 | buy |
| Hudson Bay Capital Management LP | 130,133 | 916,527 | +786,394 | 0.01 | 0.02 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 2,471,704 | 3,010,727 | +539,023 | 1.54 | 0.60 | -0.94 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 148,018 | 418,890 | +270,872 | 0.01 | 0.01 | -0.00 | buy |
| Atle Fund Management AB | 49,307 | 143,407 | +94,100 | 0.44 | 0.37 | -0.07 | buy |
| Vestal Point Capital, LP | 725,000 | 800,000 | +75,000 | 0.88 | 0.25 | -0.63 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 418,282 | 475,056 | +56,774 | 0.03 | 0.01 | -0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 105,787 | 129,996 | +24,209 | 0.07 | 0.01 | -0.06 | buy |
| VIRTUS ADVISERS, LLC | 9,309 | 19,343 | +10,034 | 0.07 | 0.04 | -0.03 | buy |
| Diversified Trust Co | 13,630 | 18,097 | +4,467 | 0.01 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 365,425 | 369,542 | +4,117 | 0.05 | 0.01 | -0.03 | buy |
| Sound Income Strategies, LLC | 5,252 | 7,262 | +2,010 | 0.01 | 0.00 | 0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 40,340 | 41,742 | +1,402 | 0.00 | 0.00 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 16,217 | 16,025 | -192 | 0.04 | 0.01 | -0.03 | sell |
| Fortitude Family Office, LLC | 734 | 455 | -279 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 11,935 | 7,357 | -4,578 | 0.02 | 0.00 | -0.02 | sell |
| PINNACLE ASSOCIATES LTD | 647,235 | 637,319 | -9,916 | 0.15 | 0.04 | -0.11 | sell |
| Bellevue Group AG | 9,965,862 | 9,942,313 | -23,549 | 2.24 | 0.69 | -1.55 | sell |
| Atom Investors LP | 104,845 | 78,005 | -26,840 | 0.19 | 0.03 | -0.16 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 478,079 | 370,000 | -108,079 | 1.97 | 0.39 | -1.59 | sell |
| Ikarian Capital, LLC | 318,167 | 200,079 | -118,088 | 0.51 | 0.15 | -0.37 | sell |
| Rock Springs Capital Management LP | 1,305,250 | 1,053,647 | -251,603 | 0.49 | 0.13 | -0.35 | sell |