| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARMISTICE CAPITAL, LLC | 2,400,000 | 6,000,000 | +3,600,000 | 0.94 | 0.67 | -0.27 | buy |
| MILLENNIUM MANAGEMENT LLC | 92,695 | 3,312,672 | +3,219,977 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 989,579 | 2,451,797 | +1,462,218 | 0.08 | 0.06 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,363 | 1,223,993 | +1,210,630 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 1,151,400 | +1,151,400 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 130,133 | 916,527 | +786,394 | 0.02 | 0.03 | +0.01 | buy |
| MARSHALL WACE, LLP | 36,775 | 658,007 | +621,232 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 2,471,704 | 3,010,727 | +539,023 | 1.54 | 0.60 | -0.94 | buy |
| VANGUARD GROUP INC | 3,677,678 | 4,135,319 | +457,641 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 463,430 | 741,490 | +278,060 | 0.04 | 0.02 | -0.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 148,018 | 418,890 | +270,872 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 211,948 | 472,237 | +260,289 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 218,856 | +218,856 | 0.00 | 0.09 | +0.09 | buy |
| Walleye Capital LLC | 47,315 | 203,945 | +156,630 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 346,325 | 476,526 | +130,201 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 122,782 | +122,782 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 114,060 | +114,060 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 473,413 | 586,079 | +112,666 | 0.02 | 0.01 | -0.02 | buy |
| PDT Partners, LLC | 0 | 110,751 | +110,751 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 378,523 | 487,201 | +108,678 | 0.01 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 95,689 | +95,689 | 0.00 | 0.03 | +0.03 | buy |
| Atle Fund Management AB | 49,307 | 143,407 | +94,100 | 0.44 | 0.37 | -0.07 | buy |
| EntryPoint Capital, LLC | 2,695 | 82,079 | +79,384 | 0.04 | 0.16 | +0.13 | buy |
| HRT FINANCIAL LP | 0 | 75,042 | +75,042 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 725,000 | 800,000 | +75,000 | 0.88 | 0.25 | -0.63 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 23,915 | 91,327 | +67,412 | 0.00 | 0.00 | +0.00 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 66,617 | +66,617 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 82,030 | 143,161 | +61,131 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 418,282 | 475,056 | +56,774 | 0.03 | 0.01 | -0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 26,900 | 67,782 | +40,882 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,030 | 102,730 | +35,700 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 34,400 | +34,400 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 36,900 | 67,900 | +31,000 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 53,620 | 79,458 | +25,838 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 105,787 | 129,996 | +24,209 | 0.07 | 0.01 | -0.06 | buy |
| Brevan Howard Capital Management LP | 0 | 21,522 | +21,522 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 245,831 | 265,407 | +19,576 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 10,983 | 30,458 | +19,475 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 11,720 | 28,657 | +16,937 | 0.01 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 78,874 | 95,698 | +16,824 | 0.00 | 0.00 | -0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 0 | 14,800 | +14,800 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 2,984 | 17,344 | +14,360 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 14,334 | +14,334 | 0.00 | 0.01 | +0.01 | buy |
| DRW Securities, LLC | 0 | 13,105 | +13,105 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,325 | +12,325 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 249,707 | 261,944 | +12,237 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,012 | 16,072 | +12,060 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,309 | 19,343 | +10,034 | 0.07 | 0.04 | -0.03 | buy |
| OSAIC HOLDINGS, INC. | 0 | 7,770 | +7,770 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 31,210 | 35,681 | +4,471 | 0.00 | 0.00 | -0.00 | buy |
| Diversified Trust Co | 13,630 | 18,097 | +4,467 | 0.01 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 365,425 | 369,542 | +4,117 | 0.05 | 0.02 | -0.03 | buy |
| NATIONAL BANK OF CANADA /FI/ | 1,190 | 5,190 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 344,603 | 348,421 | +3,818 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 119,549 | 122,032 | +2,483 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 15,958 | 18,390 | +2,432 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 33,179 | 35,551 | +2,372 | 0.00 | 0.00 | -0.00 | buy |
| Sound Income Strategies, LLC | 5,252 | 7,262 | +2,010 | 0.01 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Manchester Capital Management LLC | 0 | 1,420 | +1,420 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 40,340 | 41,742 | +1,402 | 0.00 | 0.00 | -0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 1,233 | +1,233 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,152 | 21,323 | +1,171 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 113 | 754 | +641 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 560 | +560 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,785 | 13,134 | +349 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 279 | +279 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,171 | 23,444 | +273 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,708 | 20,976 | +268 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,230 | 23,400 | +170 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 57 | 179 | +122 | 0.00 | 0.00 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 6,238 | 6,261 | +23 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 20 | +10 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 3,508 | 3,508 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,300 | 6,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 2,082,021 | 2,082,021 | 0 | 0.39 | 0.12 | -0.27 | hold |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 209 | 209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 91,800 | 91,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 81 | 81 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Northeast Financial Consultants Inc | 10,000 | 10,000 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Pennant Investors, LP | 43,800 | 43,800 | 0 | 0.18 | 0.05 | -0.13 | hold |
| XML Financial, LLC | 10,600 | 10,600 | 0 | 0.02 | 0.00 | -0.01 | hold |
| HighMark Wealth Management LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Spire Wealth Management | 664 | 664 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 44 | 44 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,067 | 2,067 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 47 | 22 | -25 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,353 | 10,296 | -57 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 16,217 | 16,025 | -192 | 0.04 | 0.01 | -0.03 | sell |
| Fortitude Family Office, LLC | 734 | 455 | -279 | 0.01 | 0.00 | -0.01 | sell |
| ADIRONDACK TRUST CO | 294 | 0 | -294 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 33,403 | 33,100 | -303 | 0.00 | 0.00 | -0.00 | sell |