| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 9,929,963 | 9,919,992 | -9,971 | 0.28 | 0.26 | -0.02 | sell |
| ARMISTICE CAPITAL, LLC | 6,296,000 | 5,960,000 | -336,000 | 0.21 | 0.27 | +0.06 | sell |
| VANGUARD GROUP INC | 4,425,992 | 4,213,114 | -212,878 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 3,250,248 | 3,251,022 | +774 | 0.02 | 0.02 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,175,665 | 3,175,665 | 0 | 0.18 | 0.15 | -0.03 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 2,308,649 | 2,491,703 | +183,054 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,724,250 | 2,015,864 | +291,614 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,913,128 | 1,817,529 | -3,095,599 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 0 | 1,602,717 | +1,602,717 | 0.00 | 0.11 | +0.11 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,152,270 | 1,326,494 | +174,224 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 665,351 | 1,004,798 | +339,447 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,068,200 | 857,100 | -211,100 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 246,427 | 758,204 | +511,777 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 197,696 | 698,288 | +500,592 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,456,188 | 683,538 | -772,650 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 816,054 | 682,277 | -133,777 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 645,625 | 508,803 | -136,822 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 745,062 | 460,137 | -284,925 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 654,898 | 407,288 | -247,610 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 299,028 | 405,911 | +106,883 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 352,105 | +352,105 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 476,496 | 350,967 | -125,529 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,535 | 334,349 | -191,186 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,409,312 | 300,287 | -1,109,025 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 280,000 | 280,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 219,000 | +219,000 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 218,856 | 218,856 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Amundi | 214,278 | 214,278 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 188,711 | 188,711 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITADEL ADVISORS LLC | 0 | 171,578 | +171,578 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 521,269 | 152,913 | -368,356 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 115,200 | 133,700 | +18,500 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 52,425 | 104,751 | +52,326 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 31,170 | 102,714 | +71,544 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 28,700 | 100,511 | +71,811 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 88,059 | +88,059 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 80,071 | 80,071 | 0 | 0.03 | 0.03 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 232,399 | 75,529 | -156,870 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 67,758 | +67,758 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 248,235 | 63,915 | -184,320 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 68,377 | 61,032 | -7,345 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 59,339 | +59,339 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 110,137 | 57,818 | -52,319 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 10,486 | 55,483 | +44,997 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 50,211 | +50,211 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 1,614 | 49,564 | +47,950 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 105,143 | 46,132 | -59,011 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,075 | 45,200 | -19,875 | 0.00 | 0.00 | -0.00 | sell |
| SPC Financial, Inc. | 37,750 | 37,750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 45,857 | 35,190 | -10,667 | 0.00 | 0.00 | -0.00 | sell |
| XML Financial, LLC | 19,169 | 32,336 | +13,167 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 22,262 | 31,557 | +9,295 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 34,016 | 31,318 | -2,698 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 29,945 | +29,945 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 28,500 | +28,500 | 0.00 | 0.01 | +0.01 | buy |
| Rangeley Capital, LLC | 0 | 27,000 | +27,000 | 0.00 | 0.04 | +0.04 | buy |
| STIFEL FINANCIAL CORP | 27,373 | 26,217 | -1,156 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,182 | 25,982 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 25,180 | +25,180 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 24,665 | +24,665 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 23,512 | 23,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Engineers Gate Manager LP | 0 | 23,291 | +23,291 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 21,105 | +21,105 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 22,261 | 20,679 | -1,582 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 86,765 | 20,000 | -66,765 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 0 | 18,196 | +18,196 | 0.00 | 0.00 | +0.00 | buy |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 17,483 | +17,483 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 16,429 | 16,429 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 0 | 15,483 | +15,483 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,589 | 12,671 | +82 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 11,534 | +11,534 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 40,440 | 11,018 | -29,422 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 0 | 10,137 | +10,137 | 0.00 | 0.00 | +0.00 | buy |
| Northeast Financial Consultants Inc | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 5,227 | 7,509 | +2,282 | 0.00 | 0.00 | +0.00 | buy |
| Sound Income Strategies, LLC | 7,262 | 7,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 6,421 | 5,844 | -577 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 8,408 | 5,448 | -2,960 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 5,010 | +5,010 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 3,043 | 3,059 | +16 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,100 | 2,437 | +337 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 2,398 | 2,398 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUMMIT SECURITIES GROUP LLC | 0 | 2,157 | +2,157 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,557 | 1,557 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Manchester Capital Management LLC | 1,245 | 1,245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IMG Wealth Management, Inc. | 1,150 | 1,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Spire Wealth Management | 664 | 664 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cornerstone Planning Group LLC | 560 | 560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,983 | 499 | -1,484 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 363 | +363 | 0.00 | 0.00 | +0.00 | buy |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 209 | 209 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 190 | +190 | 0.00 | 0.00 | +0.00 | buy |
| FARMERS & MERCHANTS INVESTMENTS INC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 18 | 56 | +38 | 0.00 | 0.00 | 0.00 | buy |
| EverSource Wealth Advisors, LLC | 65 | 47 | -18 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 44 | 44 | 0 | 0.00 | 0.00 | -0.00 | hold |