| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 9,942,313 | 9,929,963 | -12,350 | 0.69 | 0.53 | -0.16 | sell |
| ARMISTICE CAPITAL, LLC | 6,000,000 | 6,258,000 | +258,000 | 0.67 | 0.54 | -0.13 | buy |
| VANGUARD GROUP INC | 4,135,319 | 4,357,540 | +222,221 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,312,672 | 3,535,900 | +223,228 | 0.01 | 0.01 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,010,727 | 3,010,727 | 0 | 0.60 | 0.40 | -0.20 | hold |
| WASATCH ADVISORS LP | 2,451,797 | 2,535,802 | +84,005 | 0.06 | 0.04 | -0.01 | buy |
| STATE STREET CORP | 1,542,590 | 1,427,390 | -115,200 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,415,239 | 1,406,876 | -8,363 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,337,020 | 1,254,236 | -82,784 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 586,079 | 1,091,825 | +505,746 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,053,647 | 1,053,647 | 0 | 0.14 | 0.11 | -0.02 | hold |
| TWO SIGMA ADVISERS, LP | 1,151,400 | 1,044,004 | -107,396 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,223,993 | 883,369 | -340,624 | 0.01 | 0.01 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 898,497 | 882,660 | -15,837 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 800,000 | 830,000 | +30,000 | 0.25 | 0.22 | -0.04 | buy |
| NORTHERN TRUST CORP | 712,168 | 702,820 | -9,348 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 637,319 | 687,980 | +50,661 | 0.04 | 0.11 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 475,056 | 661,914 | +186,858 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 418,890 | 566,328 | +147,438 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 487,201 | 522,197 | +34,996 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 510,505 | 492,765 | -17,740 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 143,161 | 423,616 | +280,455 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 658,007 | 381,516 | -276,491 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 741,490 | 354,835 | -386,655 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 480,261 | 324,902 | -155,359 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 484,027 | 318,423 | -165,604 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 265,407 | 307,140 | +41,733 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 476,526 | 228,446 | -248,080 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 218,856 | 218,856 | 0 | 0.09 | 0.05 | -0.04 | hold |
| Bank of New York Mellon Corp | 261,944 | 218,561 | -43,383 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 95,689 | 207,877 | +112,188 | 0.03 | 0.05 | +0.02 | buy |
| Woodline Partners LP | 369,542 | 188,711 | -180,831 | 0.02 | 0.01 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 169,000 | 169,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 110,751 | 160,039 | +49,288 | 0.04 | 0.05 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 119,759 | 142,146 | +22,387 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 10,316 | 137,215 | +126,899 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 122,032 | 121,278 | -754 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 114,060 | 119,029 | +4,969 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 203,945 | 114,744 | -89,201 | 0.01 | 0.00 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 108,131 | 107,293 | -838 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 102,730 | 102,730 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 45,114 | 98,753 | +53,639 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 19,136 | 90,779 | +71,643 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 90,304 | +90,304 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 85,541 | 86,012 | +471 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 88,294 | 82,667 | -5,627 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 79,458 | 80,878 | +1,420 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 200,079 | 80,079 | -120,000 | 0.27 | 0.08 | -0.18 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 91,327 | 72,879 | -18,448 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 67,900 | 67,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 21,323 | 58,993 | +37,670 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 56,018 | +56,018 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 13,532 | 48,823 | +35,291 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,087 | 47,883 | -54,204 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 24,635 | 45,643 | +21,008 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,564 | 43,855 | +10,291 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 21,522 | 41,706 | +20,184 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 41,742 | 40,754 | -988 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 33,310 | 39,888 | +6,578 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 37,170 | +37,170 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 35,681 | 34,748 | -933 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,913 | 34,253 | +3,340 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 33,068 | 32,865 | -203 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 95,698 | 32,775 | -62,923 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,193 | +31,193 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 30,458 | 29,658 | -800 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 28,657 | 29,615 | +958 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 82,079 | 28,173 | -53,906 | 0.16 | 0.05 | -0.11 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 58,763 | 23,520 | -35,243 | 0.01 | 0.00 | -0.01 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,400 | 23,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 0 | 21,320 | +21,320 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 20,763 | +20,763 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,976 | 20,526 | -450 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 19,343 | 19,694 | +351 | 0.04 | 0.03 | -0.01 | buy |
| Diversified Trust Co | 18,097 | 18,097 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XML Financial, LLC | 10,600 | 17,600 | +7,000 | 0.00 | 0.01 | +0.00 | buy |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SG Americas Securities, LLC | 0 | 16,822 | +16,822 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 18,390 | 16,114 | -2,276 | 0.00 | 0.00 | -0.00 | sell |
| Pathstone Holdings, LLC | 17,687 | 15,894 | -1,793 | 0.00 | 0.00 | -0.00 | sell |
| Cerity Partners LLC | 0 | 15,647 | +15,647 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,018 | 15,321 | +3,303 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 35,551 | 15,093 | -20,458 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,357 | 12,064 | +4,707 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 11,178 | +11,178 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 179 | 10,152 | +9,973 | 0.00 | 0.00 | +0.00 | buy |
| Northeast Financial Consultants Inc | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,266 | 8,266 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sound Income Strategies, LLC | 7,262 | 7,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 754 | 6,707 | +5,953 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 47,959 | 6,452 | -41,507 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,300 | 6,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 6,261 | 6,120 | -141 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,444 | 5,244 | -18,200 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,123 | 4,454 | -42,669 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 25,000 | 3,135 | -21,865 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 17,344 | 2,987 | -14,357 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,870 | 2,269 | +399 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,067 | 2,067 | 0 | 0.00 | 0.00 | -0.00 | hold |