| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 9,919,992 | 9,919,992 | 0 | 0.26 | 0.35 | +0.08 | hold |
| ARMISTICE CAPITAL, LLC | 5,960,000 | 5,960,000 | 0 | 0.27 | 0.31 | +0.04 | hold |
| VANGUARD GROUP INC | 4,213,114 | 4,224,234 | +11,120 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 3,175,665 | 3,175,665 | 0 | 0.15 | 0.16 | +0.01 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 2,491,703 | 2,517,547 | +25,844 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,015,864 | 2,116,870 | +101,006 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 3,251,022 | 1,950,287 | -1,300,735 | 0.02 | 0.02 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,326,494 | 1,701,223 | +374,729 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,817,529 | 1,538,694 | -278,835 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 989,233 | +989,233 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 758,204 | 846,694 | +88,490 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,004,798 | 815,865 | -188,933 | 0.00 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 460,137 | 755,245 | +295,108 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 857,100 | 748,600 | -108,500 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 682,277 | 710,608 | +28,331 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 683,538 | 657,521 | -26,017 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 405,911 | 629,535 | +223,624 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 171,578 | 493,531 | +321,953 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 407,288 | 437,091 | +29,803 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 55,483 | 385,633 | +330,150 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 508,803 | 345,582 | -163,221 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 350,967 | 338,106 | -12,861 | 0.01 | 0.01 | +0.00 | sell |
| Voleon Capital Management LP | 0 | 307,395 | +307,395 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 280,000 | 280,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| STATE STREET CORP | 300,287 | 274,587 | -25,700 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 698,288 | 258,662 | -439,626 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 223,793 | +223,793 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 100,511 | 222,200 | +121,689 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 218,856 | 218,856 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 210,000 | +210,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 15,483 | 173,959 | +158,476 | 0.00 | 0.02 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 160,000 | +160,000 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 152,913 | 151,141 | -1,772 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 352,105 | 109,226 | -242,879 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 104,751 | 95,275 | -9,476 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 133,700 | 88,700 | -45,000 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 88,130 | +88,130 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 46,132 | 86,671 | +40,539 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 61,032 | 84,453 | +23,421 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 80,071 | 80,071 | 0 | 0.03 | 0.03 | -0.00 | hold |
| FMR LLC | 63,915 | 63,334 | -581 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 0 | 61,200 | +61,200 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 60,801 | +60,801 | 0.00 | 0.01 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 28,500 | 54,600 | +26,100 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 49,564 | 49,105 | -459 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 21,105 | 42,714 | +21,609 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 25,982 | 42,382 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 57,818 | 39,306 | -18,512 | 0.00 | 0.00 | -0.00 | sell |
| SPC Financial, Inc. | 37,750 | 37,750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XML Financial, LLC | 32,336 | 32,336 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SEI INVESTMENTS CO | 31,318 | 31,318 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rangeley Capital, LLC | 27,000 | 30,220 | +3,220 | 0.04 | 0.05 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 334,349 | 30,008 | -304,341 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 25,180 | 25,180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 50,211 | 25,105 | -25,106 | 0.01 | 0.01 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 26,217 | 23,920 | -2,297 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 23,512 | 23,512 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 0 | 22,415 | +22,415 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 20,000 | 21,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 11,018 | 17,179 | +6,161 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 20,679 | 16,763 | -3,916 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 16,429 | 16,429 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corient Private Wealth LLC | 0 | 14,624 | +14,624 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,688 | +13,688 | 0.00 | 0.00 | +0.00 | buy |
| SANDERS MORRIS HARRIS LLC | 0 | 12,345 | +12,345 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 11,166 | +11,166 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,671 | 11,079 | -1,592 | 0.00 | 0.00 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 0 | 10,579 | +10,579 | 0.00 | 0.00 | +0.00 | buy |
| Sound Income Strategies, LLC | 7,262 | 7,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 5,010 | 7,124 | +2,114 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 3,059 | 3,059 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,437 | 2,444 | +7 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 35,190 | 1,779 | -33,411 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,557 | 1,303 | -254 | 0.00 | 0.00 | +0.00 | sell |
| Manchester Capital Management LLC | 1,245 | 1,245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IMG Wealth Management, Inc. | 1,150 | 1,150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 2,398 | 1,008 | -1,390 | 0.00 | 0.00 | -0.00 | sell |
| Spire Wealth Management | 664 | 664 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cornerstone Planning Group LLC | 560 | 560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 499 | 499 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighMark Wealth Management LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 363 | 363 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 213 | 213 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 209 | 209 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Point72 (DIFC) Ltd | 190 | 190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Caitong International Asset Management Co., Ltd | 0 | 133 | +133 | 0.00 | 0.00 | +0.00 | buy |
| FARMERS & MERCHANTS INVESTMENTS INC | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Advisory Services Network, LLC | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 56 | 56 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 44 | 44 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 75,529 | 0 | -75,529 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 214,278 | 0 | -214,278 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 17,483 | 0 | -17,483 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 102,714 | 0 | -102,714 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 18,196 | 0 | -18,196 | 0.00 | 0.00 | -0.00 | sell |