| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 1,803,204 | 2,401,704 | +598,500 | 0.56 | 1.24 | +0.68 | buy |
| Bellevue Group AG | 9,803,313 | 9,953,313 | +150,000 | 0.74 | 1.46 | +0.73 | buy |
| T. Rowe Price Investment Management, Inc. | 5,491,952 | 5,639,994 | +148,042 | 0.02 | 0.04 | +0.02 | buy |
| Atom Investors LP | 29,649 | 139,090 | +109,441 | 0.03 | 0.24 | +0.20 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 139,251 | 244,196 | +104,945 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 225,918 | 123,716 | +102,202 | 0.10 | 0.11 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 1,597 | 7,174 | +5,577 | 0.00 | 0.01 | +0.01 | buy |
| Diversified Trust Co | 12,158 | 11,750 | -408 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 16,286 | 15,482 | -804 | 0.00 | 0.00 | +0.00 | sell |
| XML Financial, LLC | 14,600 | 10,600 | -4,000 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 45,694 | 41,674 | -4,020 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,264,158 | 1,258,641 | -5,517 | 2.19 | 3.73 | +1.54 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 35,343 | 29,110 | -6,233 | 0.03 | 0.05 | +0.02 | sell |
| PINNACLE ASSOCIATES LTD | 697,067 | 687,980 | -9,087 | 0.06 | 0.11 | +0.05 | sell |
| WINTON GROUP Ltd | 31,647 | 16,333 | -15,314 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 194,204 | 165,107 | -29,097 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 52,396 | 15,168 | -37,228 | 0.02 | 0.15 | +0.13 | sell |
| DAFNA Capital Management LLC | 258,496 | 152,250 | -106,246 | 0.37 | 0.35 | -0.02 | sell |
| WASATCH ADVISORS LP | 1,409,534 | 1,297,574 | -111,960 | 0.04 | 0.07 | +0.03 | sell |
| ARMISTICE CAPITAL, LLC | 4,712,000 | 4,572,000 | -140,000 | 0.34 | 0.60 | +0.26 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 399,484 | 114,979 | -284,505 | 0.01 | 0.01 | -0.01 | sell |