| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 342,000 | 4,053,077 | +3,711,077 | 0.03 | 0.61 | +0.58 | buy |
| STATE STREET CORP | 1,300,401 | 2,174,022 | +873,621 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 611,932 | +611,932 | 0.00 | 0.13 | +0.13 | buy |
| Frazier Life Sciences Management, L.P. | 1,803,204 | 2,401,704 | +598,500 | 0.56 | 1.24 | +0.68 | buy |
| Integral Health Asset Management, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.63 | +0.63 | buy |
| DEUTSCHE BANK AG\ | 25,155 | 188,332 | +163,177 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 156,493 | +156,493 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 9,803,313 | 9,953,313 | +150,000 | 0.74 | 1.46 | +0.73 | buy |
| T. Rowe Price Investment Management, Inc. | 5,491,952 | 5,639,994 | +148,042 | 0.02 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 502,058 | 617,963 | +115,905 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 29,649 | 139,090 | +109,441 | 0.03 | 0.24 | +0.20 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 139,251 | 244,196 | +104,945 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 665,150 | 763,527 | +98,377 | 0.01 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 94,732 | +94,732 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 93,005 | +93,005 | 0.00 | 0.08 | +0.08 | buy |
| JPMORGAN CHASE & CO | 1,050,570 | 1,134,744 | +84,174 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,320,000 | 1,404,068 | +84,068 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 76,246 | +76,246 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 110,582 | 182,484 | +71,902 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 198,847 | 265,072 | +66,225 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 14,318 | 72,839 | +58,521 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 51,366 | +51,366 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 49,193 | +49,193 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 45,003 | +45,003 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 2,185 | 46,471 | +44,286 | 0.00 | 0.00 | +0.00 | buy |
| Pennant Investors, LP | 0 | 43,800 | +43,800 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 100,471 | 133,011 | +32,540 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 0 | 30,892 | +30,892 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 30,546 | +30,546 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 11,252 | 38,947 | +27,695 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,226 | 42,109 | +24,883 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 134,273 | 157,531 | +23,258 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 378,660 | 398,944 | +20,284 | 0.01 | 0.02 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,400 | 30,200 | +19,800 | 0.00 | 0.03 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 18,911 | +18,911 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 0 | 16,424 | +16,424 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 24,840 | 40,834 | +15,994 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 15,902 | +15,902 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 8,524 | 24,365 | +15,841 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 14,060 | +14,060 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 64,848 | 75,048 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 9,944 | +9,944 | 0.00 | 0.06 | +0.06 | buy |
| ROYAL BANK OF CANADA | 19,961 | 28,837 | +8,876 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 825,389 | 833,500 | +8,111 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,877 | 28,589 | +7,712 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 22,456 | 30,085 | +7,629 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 27,332 | 33,870 | +6,538 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 4,173 | 10,580 | +6,407 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,597 | 7,174 | +5,577 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 770,170 | 774,479 | +4,309 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,477 | 18,046 | +3,569 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 46,018 | 49,337 | +3,319 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,955 | 14,036 | +2,081 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,499 | 6,300 | +1,801 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 1,456 | +1,456 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,099 | 9,457 | +1,358 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 500 | 1,479 | +979 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 15,602 | 16,536 | +934 | 0.00 | 0.00 | +0.00 | buy |
| ADIRONDACK TRUST CO | 0 | 294 | +294 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 43,186 | 43,279 | +93 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 57,835 | 57,847 | +12 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 107,600 | 107,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 60,329 | 60,329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FARMERS & MERCHANTS INVESTMENTS INC | 80 | 80 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 209 | 209 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 33,179 | 33,179 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rock Springs Capital Management LP | 1,178,796 | 1,178,796 | 0 | 0.15 | 0.28 | +0.13 | hold |
| Capital Advisors, Ltd. LLC | 81 | 81 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Northeast Financial Consultants Inc | 10,000 | 10,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| HighMark Wealth Management LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,285 | 3,285 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 190 | 190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 213 | 213 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 6,180 | 6,180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,400 | 23,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Headlands Technologies LLC | 37 | 0 | -37 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 71,015 | 70,977 | -38 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,783 | 18,694 | -89 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 117 | 27 | -90 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 30,373 | 30,251 | -122 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 90,674 | 90,449 | -225 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,250 | 1,997 | -253 | 0.00 | 0.00 | +0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 363 | 0 | -363 | 0.00 | 0.00 | -0.00 | sell |
| Diversified Trust Co | 12,158 | 11,750 | -408 | 0.00 | 0.00 | +0.00 | sell |
| Spire Wealth Management | 1,114 | 614 | -500 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 6,933 | 6,318 | -615 | 0.00 | 0.00 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 16,286 | 15,482 | -804 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 88,311 | 87,088 | -1,223 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 52,563 | 51,063 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 353,277 | 351,175 | -2,102 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 12,144 | 9,144 | -3,000 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,748 | 22,464 | -3,284 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,429 | 10,017 | -3,412 | 0.00 | 0.00 | +0.00 | sell |
| XML Financial, LLC | 14,600 | 10,600 | -4,000 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 45,694 | 41,674 | -4,020 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,011 | 28,813 | -4,198 | 0.00 | 0.00 | +0.00 | sell |