| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Bellevue Group AG | 9,929,963 | 9,929,963 | 0 | 0.53 | 0.62 | +0.09 | hold |
| ARMISTICE CAPITAL, LLC | 6,258,000 | 6,276,000 | +18,000 | 0.54 | 0.47 | -0.06 | buy |
| BlackRock, Inc. | 5,405,472 | 5,057,175 | -348,297 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 4,357,540 | 4,316,681 | -40,859 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 2,535,802 | 3,488,493 | +952,691 | 0.04 | 0.06 | +0.02 | buy |
| Frazier Life Sciences Management, L.P. | 3,010,727 | 3,175,665 | +164,938 | 0.40 | 0.43 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,535,900 | 2,864,721 | -671,179 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 1,427,390 | 1,462,532 | +35,142 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,406,876 | 1,433,217 | +26,341 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,091,825 | 1,290,923 | +199,098 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,044,004 | 1,118,600 | +74,596 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 0 | 1,104,426 | +1,104,426 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 1,053,647 | 1,053,647 | 0 | 0.11 | 0.13 | +0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 883,369 | 860,745 | -22,624 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 857,505 | +857,505 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 661,914 | 744,902 | +82,988 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 882,660 | 717,288 | -165,372 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 566,328 | 565,904 | -424 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 324,902 | 546,807 | +221,905 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 702,820 | 540,970 | -161,850 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 318,423 | 538,523 | +220,100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 492,765 | 527,185 | +34,420 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 687,980 | 501,850 | -186,130 | 0.11 | 0.02 | -0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,254,236 | 485,987 | -768,249 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 522,197 | 454,337 | -67,860 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 420,000 | 420,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 381,516 | 393,766 | +12,250 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 228,446 | 351,136 | +122,690 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 307,140 | 323,857 | +16,717 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 423,616 | 319,070 | -104,546 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 830,000 | 280,000 | -550,000 | 0.22 | 0.05 | -0.16 | sell |
| PANAGORA ASSET MANAGEMENT INC | 354,835 | 255,745 | -99,090 | 0.01 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 207,877 | 246,604 | +38,727 | 0.05 | 0.06 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 218,856 | 218,856 | 0 | 0.05 | 0.05 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 142,146 | 201,151 | +59,005 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 188,711 | 188,711 | 0 | 0.01 | 0.00 | -0.00 | hold |
| FMR LLC | 137,215 | 174,496 | +37,281 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 86,012 | 169,959 | +83,947 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 218,561 | 166,122 | -52,439 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 121,278 | 121,026 | -252 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 111,993 | +111,993 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 98,753 | 111,891 | +13,138 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 67,900 | 111,300 | +43,400 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 104,000 | +104,000 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 102,730 | 102,730 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 90,779 | 92,859 | +2,080 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 129,996 | 89,134 | -40,862 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 82,667 | 85,217 | +2,550 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 80,079 | 80,071 | -8 | 0.08 | 0.07 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,883 | 76,824 | +28,941 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,178 | 66,742 | +55,564 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 58,993 | 57,422 | -1,571 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 80,878 | 54,334 | -26,544 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 50,750 | +50,750 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 45,643 | 50,149 | +4,506 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 48,823 | 48,823 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 169,000 | 43,400 | -125,600 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 15,093 | 39,669 | +24,576 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 114,744 | 38,353 | -76,391 | 0.00 | 0.00 | -0.00 | sell |
| SPC Financial, Inc. | 0 | 37,750 | +37,750 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 34,748 | 35,979 | +1,231 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,253 | 34,979 | +726 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 16,822 | 34,399 | +17,577 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 32,865 | 30,558 | -2,307 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 20,763 | 29,864 | +9,101 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,526 | 29,838 | +9,312 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 27,410 | +27,410 | 0.00 | 0.04 | +0.04 | buy |
| PDT Partners, LLC | 160,039 | 27,389 | -132,650 | 0.05 | 0.01 | -0.04 | sell |
| STIFEL FINANCIAL CORP | 39,888 | 25,861 | -14,027 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 23,520 | 23,512 | -8 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,400 | 23,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XML Financial, LLC | 17,600 | 23,169 | +5,569 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 29,658 | 21,158 | -8,500 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 15,321 | 20,284 | +4,963 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 21,320 | 18,717 | -2,603 | 0.00 | 0.00 | +0.00 | sell |
| Diversified Trust Co | 18,097 | 18,097 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Evercore Wealth Management, LLC | 17,543 | 17,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 13,600 | +13,600 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,064 | 13,308 | +1,244 | 0.00 | 0.00 | -0.00 | buy |
| Cerity Partners LLC | 15,647 | 12,921 | -2,726 | 0.00 | 0.00 | -0.00 | sell |
| SANDERS MORRIS HARRIS LLC | 0 | 12,345 | +12,345 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 11,743 | +11,743 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 15,894 | 11,281 | -4,613 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 31,193 | 10,950 | -20,243 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 9,869 | +9,869 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10,152 | 9,282 | -870 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,266 | 8,266 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sound Income Strategies, LLC | 7,262 | 7,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 6,707 | 6,421 | -286 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,300 | 6,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 6,120 | 6,165 | +45 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 6,452 | 6,140 | -312 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,244 | 5,244 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,454 | 4,454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,987 | 3,466 | +479 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 1,028 | 2,889 | +1,861 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,269 | 2,091 | -178 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,067 | 2,067 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,707 | 1,707 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 16,114 | 1,586 | -14,528 | 0.00 | 0.00 | -0.00 | sell |