| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,281,023 | 5,872,882 | +591,859 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 500,000 | +500,000 | 0.00 | 1.23 | +1.23 | buy |
| PFM Health Sciences, LP | 0 | 368,929 | +368,929 | 0.00 | 0.18 | +0.18 | buy |
| MORGAN STANLEY | 3,471,077 | 3,788,945 | +317,868 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 206,444 | +206,444 | 0.00 | 0.22 | +0.22 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 190,800 | +190,800 | 0.00 | 0.01 | +0.01 | buy |
| Polar Asset Management Partners Inc. | 0 | 107,684 | +107,684 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,175,613 | 2,278,905 | +103,292 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 68,300 | +68,300 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 64,771 | +64,771 | 0.00 | 0.04 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 57,953 | +57,953 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 57,109 | +57,109 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,059,018 | 1,114,297 | +55,279 | 0.02 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,059 | 63,763 | +52,704 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 310,449 | 362,226 | +51,777 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 652,400 | 691,300 | +38,900 | 0.12 | 0.19 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 34,779 | +34,779 | 0.00 | 0.00 | +0.00 | buy |
| Berger Financial Group, Inc | 0 | 26,991 | +26,991 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 48,552 | 75,246 | +26,694 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,030,520 | 1,055,522 | +25,002 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,418 | 28,885 | +20,467 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 728,436 | 747,028 | +18,592 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 90,866 | 109,445 | +18,579 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 70,290 | 88,074 | +17,784 | 0.04 | 0.06 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 684,819 | 700,389 | +15,570 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 297,626 | 313,169 | +15,543 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 15,357 | +15,357 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,809 | 44,596 | +13,787 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 12,245 | +12,245 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 241,919 | 253,756 | +11,837 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 881,635 | 892,786 | +11,151 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 9,732 | +9,732 | 0.00 | 0.00 | +0.00 | buy |
| 272 Capital LP | 0 | 5,730 | +5,730 | 0.00 | 0.02 | +0.02 | buy |
| HighMark Wealth Management LLC | 0 | 3,500 | +3,500 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 72,626 | 76,026 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 3,100 | +3,100 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 28,954 | 31,928 | +2,974 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 2,634 | +2,634 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 345,074 | 347,533 | +2,459 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 60,246 | 62,313 | +2,067 | 0.02 | 0.04 | +0.02 | buy |
| HSBC HOLDINGS PLC | 15,038 | 16,747 | +1,709 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 92,430 | 94,109 | +1,679 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 13,800 | 15,200 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,524 | 20,750 | +1,226 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 285,110 | 286,316 | +1,206 | 0.04 | 0.04 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 135,685 | 136,820 | +1,135 | 0.01 | 0.01 | +0.00 | buy |
| CWM, LLC | 100 | 871 | +771 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 10,533 | 11,188 | +655 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 42,709 | 43,008 | +299 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 42 | 224 | +182 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,060 | 13,216 | +156 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,587 | 1,657 | +70 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 18 | 62 | +44 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 35 | +35 | 0.00 | 0.00 | 0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,617 | 3,617 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,745 | 2,745 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 48,600 | 48,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 151,200 | 151,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 22,244 | 22,244 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 93 | 93 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 336 | 336 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CFM WEALTH PARTNERS LLC | 264,039 | 264,039 | 0 | 0.31 | 0.38 | +0.07 | hold |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 60,204 | 60,204 | 0 | 1.27 | 2.48 | +1.21 | hold |
| Washington Trust Advisors, Inc. | 167 | 167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRAIDWELL LP | 752,541 | 752,541 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Farther Finance Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,187 | 1,187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,560 | 10,560 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 12,403 | 12,385 | -18 | 0.00 | 0.00 | +0.00 | sell |
| Covestor Ltd | 22 | 0 | -22 | 0.00 | 0.00 | 0.00 | sell |
| SIMPLEX TRADING, LLC | 31 | 0 | -31 | 0.00 | 0.00 | 0.00 | sell |
| Bell Investment Advisors, Inc | 91 | 0 | -91 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 4,143 | 4,044 | -99 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 20,380 | 20,255 | -125 | 0.00 | 0.00 | +0.00 | sell |
| CKW FINANCIAL GROUP | 525 | 0 | -525 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,619 | 15,042 | -577 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 51,706 | 51,015 | -691 | 0.00 | 0.00 | +0.00 | sell |
| VALLEY NATIONAL ADVISERS INC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 15,978 | 14,902 | -1,076 | 0.00 | 0.00 | +0.00 | sell |
| Corton Capital Inc. | 13,779 | 12,604 | -1,175 | 0.05 | 0.05 | +0.00 | sell |
| UBS Group AG | 22,635 | 21,173 | -1,462 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,552 | 5,861 | -1,691 | 0.00 | 0.00 | +0.00 | sell |
| PURA VIDA INVESTMENTS, LLC | 512,964 | 509,775 | -3,189 | 3.93 | 6.95 | +3.02 | sell |
| Russell Investments Group, Ltd. | 42,119 | 36,369 | -5,750 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 5,855 | 0 | -5,855 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 34,234 | 27,800 | -6,434 | 0.00 | 0.00 | +0.00 | sell |
| Quantbot Technologies LP | 7,717 | 0 | -7,717 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,345 | 6,914 | -8,431 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 8,900 | 0 | -8,900 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 9,919 | 0 | -9,919 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 14,628 | 0 | -14,628 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 15,975 | 0 | -15,975 | 0.01 | 0.00 | -0.01 | sell |
| MACKENZIE FINANCIAL CORP | 16,124 | 0 | -16,124 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,200 | 0 | -16,200 | 0.01 | 0.00 | -0.01 | sell |