| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,534,763 | +1,534,763 | 0.00 | 0.20 | +0.20 | buy |
| Altium Capital Management LLC | 500,000 | 815,000 | +315,000 | 1.23 | 1.72 | +0.49 | buy |
| UBS Group AG | 21,173 | 201,838 | +180,665 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,114,297 | 1,251,864 | +137,567 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 101,453 | +101,453 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 82,070 | +82,070 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 691,300 | 772,151 | +80,851 | 0.19 | 0.20 | +0.01 | buy |
| Trexquant Investment LP | 15,357 | 93,700 | +78,343 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 159,010 | 220,510 | +61,500 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 347,533 | 408,022 | +60,489 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 54,823 | +54,823 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 54,823 | +54,823 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,795,561 | 2,850,154 | +54,593 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 0 | 51,000 | +51,000 | 0.00 | 0.28 | +0.28 | buy |
| FMR LLC | 5,872,882 | 5,923,182 | +50,300 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 144,644 | 183,069 | +38,425 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 360,787 | 392,836 | +32,049 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 28,221 | +28,221 | 0.00 | 0.04 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 57,953 | 83,941 | +25,988 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 21,555 | +21,555 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 64,771 | 85,809 | +21,038 | 0.04 | 0.04 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 34,779 | 55,237 | +20,458 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,648 | +18,648 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 14,911 | +14,911 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 13,058 | +13,058 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 747,028 | 759,328 | +12,300 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 136,820 | 149,102 | +12,282 | 0.01 | 0.01 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 11,900 | +11,900 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,669 | +10,669 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 362,226 | 372,659 | +10,433 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 892,786 | 902,240 | +9,454 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 10,430 | 18,071 | +7,641 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 6,265 | +6,265 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,385 | 18,418 | +6,033 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 5,555 | +5,555 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,278,905 | 2,283,459 | +4,554 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 12,245 | 15,555 | +3,310 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,928 | 34,738 | +2,810 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 51,015 | 53,503 | +2,488 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,169 | 315,532 | +2,363 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 28,885 | 30,350 | +1,465 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 206,444 | 207,853 | +1,409 | 0.22 | 0.19 | -0.03 | buy |
| US BANCORP \DE\ | 0 | 1,382 | +1,382 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,750 | 21,662 | +912 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 583 | +583 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,861 | 6,433 | +572 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 27,441 | 27,975 | +534 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 489 | +489 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,188 | 11,514 | +326 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 9,732 | 9,996 | +264 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 135,376 | 135,440 | +64 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 51 | +51 | 0.00 | 0.00 | 0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 62 | 85 | +23 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 93 | 106 | +13 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,617 | 3,617 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,745 | 2,745 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 48,600 | 48,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 115 | 115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORGES BANK | 151,200 | 151,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 22,244 | 22,244 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 336 | 336 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CFM WEALTH PARTNERS LLC | 264,039 | 264,039 | 0 | 0.38 | 0.30 | -0.08 | hold |
| HighMark Wealth Management LLC | 3,500 | 3,500 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Berger Financial Group, Inc | 26,991 | 26,991 | 0 | 0.02 | 0.01 | -0.00 | hold |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 60,204 | 60,204 | 0 | 2.48 | 0.94 | -1.55 | hold |
| Washington Trust Advisors, Inc. | 167 | 167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRAIDWELL LP | 752,541 | 752,541 | 0 | 0.18 | 0.15 | -0.03 | hold |
| Farther Finance Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,044 | 4,044 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,914 | 6,914 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 224 | 224 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,187 | 1,187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,560 | 10,560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 35 | 0 | -35 | 0.00 | 0.00 | 0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 51 | 0 | -51 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 871 | 817 | -54 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 65 | 0 | -65 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,657 | 1,500 | -157 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,042 | 14,475 | -567 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 19,389 | 18,617 | -772 | 0.02 | 0.02 | -0.00 | sell |
| HSBC HOLDINGS PLC | 16,747 | 15,928 | -819 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,216 | 12,300 | -916 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 62,313 | 61,326 | -987 | 0.04 | 0.03 | -0.01 | sell |
| Jefferies Financial Group Inc. | 286,316 | 285,110 | -1,206 | 0.04 | 0.02 | -0.02 | sell |
| Corebridge Financial, Inc. | 20,255 | 18,833 | -1,422 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 14,902 | 13,336 | -1,566 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 109,445 | 107,422 | -2,023 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 2,634 | 0 | -2,634 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 3,100 | 0 | -3,100 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 94,900 | 90,000 | -4,900 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 68,300 | 62,900 | -5,400 | 0.01 | 0.01 | -0.00 | sell |
| 272 Capital LP | 5,730 | 0 | -5,730 | 0.02 | 0.00 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,008 | 33,585 | -9,423 | 0.00 | 0.00 | -0.00 | sell |