| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 330,000 | +330,000 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 164,157 | 421,781 | +257,624 | 0.04 | 0.03 | -0.01 | buy |
| Vestal Point Capital, LP | 75,000 | 175,000 | +100,000 | 0.04 | 0.03 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 20,801 | 33,379 | +12,578 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 28,431 | 33,305 | +4,874 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,261 | +3,261 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 155 | 507 | +352 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 10,012 | 10,071 | +59 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 13,141 | 13,173 | +32 | 0.00 | 0.00 | -0.00 | buy |
| Banque Transatlantique SA | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 605,531 | 605,531 | 0 | 0.11 | 0.03 | -0.08 | hold |
| Pacific Capital Wealth Advisors, Inc. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Vermillion & White Wealth Management Group, LLC | 205 | 96 | -109 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,164 | 0 | -1,164 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 9,956 | 0 | -9,956 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,052 | 0 | -10,052 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 116,714 | 52,630 | -64,084 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 98,493 | 28,493 | -70,000 | 0.25 | 0.02 | -0.23 | sell |