| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ally Bridge Group (NY) LLC | 0 | 786,236 | +786,236 | 0.00 | 0.85 | +0.85 | buy |
| ORBIMED ADVISORS LLC | 605,531 | 1,203,260 | +597,729 | 0.02 | 0.02 | -0.00 | buy |
| Lynx1 Capital Management LP | 15,078 | 559,470 | +544,392 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 154,098 | 597,729 | +443,631 | 0.02 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 398,486 | +398,486 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 216,006 | +216,006 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 164,376 | +164,376 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 91,220 | +91,220 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 0 | 84,400 | +84,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 37,454 | +37,454 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 77,103 | 111,365 | +34,262 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 18,092 | +18,092 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 14,524 | +14,524 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,579 | +12,579 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 4,676 | +4,676 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,947 | +1,947 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 128 | 1,721 | +1,593 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,964 | 5,142 | +1,178 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 730,000 | 730,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 25,802 | 25,802 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Cassaday & Co Wealth Management LLC | 11 | 6 | -5 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 19,244 | 0 | -19,244 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 194,536 | 133,936 | -60,600 | 0.01 | 0.00 | -0.01 | sell |
| Palumbo Wealth Management LLC | 61,175 | 0 | -61,175 | 0.03 | 0.00 | -0.03 | sell |
| Ikarian Capital, LLC | 678,142 | 478,142 | -200,000 | 0.18 | 0.07 | -0.11 | sell |
| Dauntless Investment Group, LLC | 416,998 | 80,574 | -336,424 | 2.14 | 0.12 | -2.03 | sell |