| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,785,610 | 3,818,600 | +2,032,990 | 1.28 | 3.15 | +1.86 | buy |
| BlackRock, Inc. | 2,850,978 | 3,421,815 | +570,837 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,700,000 | 3,399,900 | +1,699,900 | 2.42 | 5.25 | +2.83 | buy |
| STATE STREET CORP | 829,521 | 2,181,901 | +1,352,380 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,507,844 | 1,507,844 | 0 | 0.45 | 0.49 | +0.04 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,017,332 | 1,118,326 | +100,994 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 447,983 | 911,976 | +463,993 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,839,876 | 821,179 | -1,018,697 | 0.08 | 0.04 | -0.04 | sell |
| FMR LLC | 922,634 | 772,649 | -149,985 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 325,000 | 590,000 | +265,000 | 2.05 | 2.35 | +0.30 | buy |
| JANE STREET GROUP, LLC | 0 | 566,081 | +566,081 | 0.00 | 0.02 | +0.02 | buy |
| J. Goldman & Co LP | 595,376 | 541,522 | -53,854 | 0.67 | 0.76 | +0.09 | sell |
| CITADEL ADVISORS LLC | 901,996 | 539,232 | -362,764 | 0.02 | 0.01 | -0.01 | sell |
| Ikarian Capital, LLC | 578,015 | 528,015 | -50,000 | 2.16 | 2.30 | +0.14 | sell |
| MORGAN STANLEY | 585,840 | 423,819 | -162,021 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 350,641 | 417,543 | +66,902 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 53,819 | 415,483 | +361,664 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 402,999 | +402,999 | 0.00 | 0.02 | +0.02 | buy |
| DG Capital Management, LLC | 413,963 | 392,096 | -21,867 | 9.61 | 5.15 | -4.45 | sell |
| UBS Group AG | 238,216 | 371,984 | +133,768 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 682,344 | 356,354 | -325,990 | 0.01 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 369,134 | 343,613 | -25,521 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 119,372 | 314,792 | +195,420 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 352,998 | 297,123 | -55,875 | 0.02 | 0.02 | -0.00 | sell |
| RTW INVESTMENTS, LP | 250,000 | 250,000 | 0 | 0.07 | 0.08 | +0.00 | hold |
| Palo Alto Investors LP | 226,304 | 229,763 | +3,459 | 0.91 | 1.07 | +0.16 | buy |
| MOODY ALDRICH PARTNERS LLC | 208,755 | 226,028 | +17,273 | 1.12 | 1.24 | +0.11 | buy |
| Trexquant Investment LP | 0 | 222,413 | +222,413 | 0.00 | 0.05 | +0.05 | buy |
| HBK Sorce Advisory LLC | 203,705 | 204,837 | +1,132 | 0.12 | 0.13 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.32 | +0.32 | buy |
| RAYMOND JAMES FINANCIAL INC | 195,390 | 196,300 | +910 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 13,621 | 185,372 | +171,751 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 242,883 | 178,383 | -64,500 | 0.30 | 0.28 | -0.02 | sell |
| Walleye Capital LLC | 0 | 177,543 | +177,543 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 190,730 | 176,145 | -14,585 | 0.14 | 0.12 | -0.02 | sell |
| Nuveen, LLC | 90,951 | 162,906 | +71,955 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 219,086 | 137,655 | -81,431 | 0.02 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 118,364 | 130,730 | +12,366 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 127,138 | +127,138 | 0.00 | 0.13 | +0.13 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 119,352 | 126,023 | +6,671 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 123,831 | +123,831 | 0.00 | 0.40 | +0.40 | buy |
| Ally Bridge Group (NY) LLC | 0 | 113,899 | +113,899 | 0.00 | 3.44 | +3.44 | buy |
| MARSHALL WACE, LLP | 121,912 | 109,531 | -12,381 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 128,270 | 108,604 | -19,666 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 104,361 | +104,361 | 0.00 | 0.04 | +0.04 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 100,000 | 0 | 0.22 | 0.20 | -0.02 | hold |
| Swiss National Bank | 0 | 96,800 | +96,800 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 90,593 | +90,593 | 0.00 | 0.17 | +0.17 | buy |
| Black Diamond Financial, LLC | 79,077 | 79,077 | 0 | 0.24 | 0.26 | +0.02 | hold |
| DIADEMA PARTNERS LP | 158,075 | 78,851 | -79,224 | 2.72 | 0.99 | -1.73 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 252 | 76,377 | +76,125 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,370 | 64,716 | +62,346 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 80,813 | 63,666 | -17,147 | 0.03 | 0.02 | -0.01 | sell |
| Rafferty Asset Management, LLC | 0 | 62,353 | +62,353 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 12,755 | 59,575 | +46,820 | 0.00 | 0.00 | +0.00 | buy |
| FOUNDATIONS INVESTMENT ADVISORS, LLC | 0 | 54,004 | +54,004 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,607 | 53,375 | -24,232 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 46,977 | 52,083 | +5,106 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 0 | 44,401 | +44,401 | 0.00 | 0.22 | +0.22 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 41,000 | 41,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 38,830 | 40,430 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 38,830 | +38,830 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 28,732 | 38,585 | +9,853 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 17,853 | 37,592 | +19,739 | 0.09 | 0.22 | +0.13 | buy |
| Legal & General Group Plc | 3,969 | 37,138 | +33,169 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 39,881 | 35,950 | -3,931 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,152 | 30,995 | +7,843 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 54,773 | 30,932 | -23,841 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 27,404 | 29,316 | +1,912 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 28,703 | +28,703 | 0.00 | 0.03 | +0.03 | buy |
| LPL Financial LLC | 46,601 | 28,002 | -18,599 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 27,958 | +27,958 | 0.00 | 0.03 | +0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,288 | 26,752 | +464 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,863 | 24,841 | +6,978 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 24,430 | +24,430 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 24,073 | +24,073 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 21,976 | 23,195 | +1,219 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 22,600 | +22,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 45,604 | 21,424 | -24,180 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 51,481 | 19,933 | -31,548 | 0.71 | 0.24 | -0.48 | sell |
| Brevan Howard Capital Management LP | 0 | 18,110 | +18,110 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 12,610 | 17,805 | +5,195 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,232 | 16,780 | +1,548 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 16,733 | +16,733 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 21,450 | 15,417 | -6,033 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 15,090 | +15,090 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 12,389 | 14,472 | +2,083 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 12,630 | 14,433 | +1,803 | 0.00 | 0.00 | +0.00 | buy |
| Dauntless Investment Group, LLC | 0 | 14,070 | +14,070 | 0.00 | 1.20 | +1.20 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,294 | 14,000 | +5,706 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 13,569 | +13,569 | 0.00 | 0.03 | +0.03 | buy |
| Arizona State Retirement System | 0 | 13,448 | +13,448 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 13,382 | +13,382 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,000 | 13,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 12,840 | +12,840 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,606 | 11,684 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,349 | 11,349 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 2,859 | 11,036 | +8,177 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |