| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Clearbridge Investments, LLC | 24,447 | 109,325 | +84,878 | 0.01 | 0.05 | +0.04 | buy |
| Artisan Partners Limited Partnership | 183,540 | 210,205 | +26,665 | 0.15 | 0.18 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 264,583 | 288,000 | +23,417 | 2.46 | 1.89 | -0.57 | buy |
| Avoro Capital Advisors LLC | 1,818,181 | 1,833,333 | +15,152 | 9.36 | 8.84 | -0.52 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 4,000 | 14,950 | +10,950 | 0.60 | 2.03 | +1.42 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 9,040 | 17,419 | +8,379 | 0.75 | 1.22 | +0.47 | buy |
| Rock Springs Capital Management LP | 170,999 | 174,999 | +4,000 | 5.28 | 4.59 | -0.69 | buy |
| EULAV Asset Management | 49,000 | 52,000 | +3,000 | 0.82 | 0.89 | +0.07 | buy |
| Bellevue Group AG | 3,040 | 4,675 | +1,635 | 0.04 | 0.05 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 2,141,701 | 2,143,131 | +1,430 | 6.44 | 5.77 | -0.67 | buy |
| SEGALL BRYANT & HAMILL, LLC | 31,870 | 32,444 | +574 | 0.24 | 0.21 | -0.03 | buy |
| Dana Investment Advisors, Inc. | 3,197 | 3,677 | +480 | 0.05 | 0.05 | +0.00 | buy |
| HighVista Strategies LLC | 2,598 | 2,852 | +254 | 0.38 | 0.35 | -0.03 | buy |
| Seelaus Asset Management LLC | 422 | 624 | +202 | 0.16 | 0.24 | +0.08 | buy |
| Abel Hall, LLC | 1,271 | 1,389 | +118 | 0.14 | 0.13 | -0.01 | buy |
| PIER 88 INVESTMENT PARTNERS LLC | 1,200 | 1,300 | +100 | 0.16 | 0.17 | +0.00 | buy |
| Verity Asset Management, Inc. | 1,164 | 1,252 | +88 | 0.26 | 0.25 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 8,616 | 8,684 | +68 | 0.15 | 0.13 | -0.02 | buy |
| INTRUST BANK NA | 863 | 903 | +40 | 0.04 | 0.04 | -0.00 | buy |
| PRAXIS INVESTMENT MANAGEMENT INC | 540 | 558 | +18 | 0.02 | 0.02 | -0.00 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 33 | 47 | +14 | 0.01 | 0.01 | +0.00 | buy |
| Dogwood Wealth Management LLC | 6 | 9 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Compagnie Lombard Odier SCmA | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| VSM Wealth Advisory, LLC | 100 | 60 | -40 | 0.00 | 0.01 | +0.01 | sell |
| TEMA ETFS LLC | 1,551 | 1,499 | -52 | 0.05 | 0.03 | -0.03 | sell |
| CASTLEARK MANAGEMENT LLC | 5,296 | 5,076 | -220 | 0.09 | 0.07 | -0.02 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 15,963 | 15,655 | -308 | 0.06 | 0.06 | -0.01 | sell |
| J. Safra Sarasin Holding AG | 2,323 | 1,950 | -373 | 0.02 | 0.02 | -0.01 | sell |
| AMI ASSET MANAGEMENT CORP | 2,613 | 2,135 | -478 | 0.09 | 0.07 | -0.02 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 23,560 | 22,985 | -575 | 0.03 | 0.02 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 4,271 | 3,669 | -602 | 0.17 | 0.12 | -0.05 | sell |
| BAMCO INC /NY/ | 5,300 | 4,500 | -800 | 0.01 | 0.00 | -0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 3,707 | 2,629 | -1,078 | 0.11 | 0.07 | -0.04 | sell |
| Calamos Advisors LLC | 3,490 | 1,642 | -1,848 | 0.01 | 0.00 | -0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 35,238 | 30,941 | -4,297 | 0.27 | 0.21 | -0.06 | sell |
| PFM Health Sciences, LP | 34,146 | 29,313 | -4,833 | 1.63 | 1.35 | -0.28 | sell |
| Candriam S.C.A. | 84,948 | 72,121 | -12,827 | 0.23 | 0.17 | -0.06 | sell |
| Rhenman & Partners Asset Management AB | 24,050 | 8,050 | -16,000 | 1.55 | 0.41 | -1.15 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 340,519 | 324,123 | -16,396 | 0.59 | 0.52 | -0.07 | sell |
| ArrowMark Colorado Holdings LLC | 62,441 | 18,624 | -43,817 | 0.87 | 0.42 | -0.45 | sell |
| PAULSON & CO. INC. | 1,392,188 | 1,340,020 | -52,168 | 23.42 | 27.94 | +4.51 | sell |
| Fiera Capital Corp | 174,011 | 99,857 | -74,154 | 0.31 | 0.19 | -0.12 | sell |
| Hood River Capital Management LLC | 249,511 | 169,084 | -80,427 | 1.31 | 0.66 | -0.65 | sell |