| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 1,105,741 | 1,775,000 | +669,259 | 23.09 | 32.74 | +9.64 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 388,729 | 803,213 | +414,484 | 0.01 | 0.03 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 151,151 | 429,953 | +278,802 | 0.78 | 2.02 | +1.24 | buy |
| MORGAN STANLEY | 151,918 | 288,606 | +136,688 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 125,205 | +125,205 | 0.00 | 0.18 | +0.18 | buy |
| ARMISTICE CAPITAL, LLC | 50,000 | 168,000 | +118,000 | 0.31 | 1.19 | +0.89 | buy |
| Artal Group S.A. | 0 | 110,507 | +110,507 | 0.00 | 0.76 | +0.76 | buy |
| Rheos Capital Works Inc. | 0 | 110,215 | +110,215 | 0.00 | 1.41 | +1.41 | buy |
| Artisan Partners Limited Partnership | 296,480 | 401,709 | +105,229 | 0.11 | 0.16 | +0.05 | buy |
| LORD, ABBETT & CO. LLC | 0 | 97,103 | +97,103 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 1,574,742 | 1,668,806 | +94,064 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 93,571 | +93,571 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 625,165 | 713,914 | +88,749 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 198,169 | 285,931 | +87,762 | 1.13 | 1.94 | +0.81 | buy |
| EcoR1 Capital, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.51 | +0.51 | buy |
| Invesco Ltd. | 8,662 | 80,192 | +71,530 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 1,888,888 | 1,944,444 | +55,556 | 6.04 | 6.06 | +0.02 | buy |
| EMERALD ADVISERS, LLC | 47,722 | 101,623 | +53,901 | 0.47 | 1.09 | +0.62 | buy |
| Sio Capital Management, LLC | 0 | 51,000 | +51,000 | 0.00 | 4.74 | +4.74 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 50,709 | +50,709 | 0.00 | 0.13 | +0.13 | buy |
| FRED ALGER MANAGEMENT, LLC | 18,097 | 64,576 | +46,479 | 0.02 | 0.09 | +0.06 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 42,986 | +42,986 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 54,107 | 93,597 | +39,490 | 0.06 | 0.11 | +0.05 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 39,083 | +39,083 | 0.00 | 0.13 | +0.13 | buy |
| Rokos Capital Management LLP | 0 | 37,762 | +37,762 | 0.00 | 0.26 | +0.26 | buy |
| UBS Group AG | 88,377 | 125,415 | +37,038 | 0.01 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 39,280 | 75,759 | +36,479 | 0.48 | 1.05 | +0.57 | buy |
| TD ASSET MANAGEMENT INC | 15,540 | 50,330 | +34,790 | 0.00 | 0.01 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 34,219 | +34,219 | 0.00 | 0.10 | +0.10 | buy |
| Ensign Peak Advisors, Inc | 61,412 | 92,218 | +30,806 | 0.03 | 0.04 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 61,508 | 92,253 | +30,745 | 0.03 | 0.05 | +0.02 | buy |
| MACQUARIE GROUP LTD | 28,500 | 58,957 | +30,457 | 0.01 | 0.02 | +0.01 | buy |
| Twin Tree Management, LP | 0 | 30,297 | +30,297 | 0.00 | 0.18 | +0.18 | buy |
| CIBC Private Wealth Group LLC | 0 | 30,050 | +30,050 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 0 | 29,973 | +29,973 | 0.00 | 0.40 | +0.40 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 5,272 | 35,112 | +29,840 | 0.01 | 0.05 | +0.04 | buy |
| Tri Locum Partners LP | 25,524 | 53,355 | +27,831 | 2.90 | 4.94 | +2.04 | buy |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.76 | +0.76 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,873 | 97,752 | +21,879 | 0.01 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 40,910 | 61,399 | +20,489 | 2.21 | 2.64 | +0.42 | buy |
| Woodline Partners LP | 0 | 19,700 | +19,700 | 0.00 | 0.05 | +0.05 | buy |
| Sofinnova Investments, Inc. | 0 | 19,029 | +19,029 | 0.00 | 0.30 | +0.30 | buy |
| Handelsbanken Fonder AB | 3,300 | 22,300 | +19,000 | 0.00 | 0.03 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 115,000 | +15,000 | 4.61 | 4.99 | +0.38 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,079 | 30,741 | +14,662 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 10,492 | 24,612 | +14,120 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 22,500 | 36,500 | +14,000 | 0.52 | 0.92 | +0.40 | buy |
| Blue Owl Capital Holdings LP | 0 | 13,319 | +13,319 | 0.00 | 0.71 | +0.71 | buy |
| Propel Bio Management, LLC | 30,032 | 43,032 | +13,000 | 5.76 | 6.69 | +0.93 | buy |
| Pictet Asset Management Holding SA | 171,165 | 184,163 | +12,998 | 0.04 | 0.05 | +0.01 | buy |
| CITIGROUP INC | 21,323 | 32,790 | +11,467 | 0.01 | 0.01 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 0 | 11,033 | +11,033 | 0.00 | 1.29 | +1.29 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 336,255 | 346,857 | +10,602 | 0.01 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 9,210 | +9,210 | 0.00 | 0.10 | +0.10 | buy |
| Simplify Asset Management Inc. | 14,294 | 23,294 | +9,000 | 0.51 | 0.60 | +0.08 | buy |
| Cubist Systematic Strategies, LLC | 1,722 | 9,013 | +7,291 | 0.00 | 0.03 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 85,103 | 91,789 | +6,686 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 5,653 | +5,653 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 5,488 | +5,488 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 16,949 | 22,357 | +5,408 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 18,300 | 23,701 | +5,401 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 26,926 | 32,318 | +5,392 | 0.36 | 0.46 | +0.11 | buy |
| AMI ASSET MANAGEMENT CORP | 4,773 | 9,618 | +4,845 | 0.06 | 0.13 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,003 | 17,527 | +4,524 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 1,182 | 5,682 | +4,500 | 0.17 | 1.41 | +1.24 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,347 | 22,399 | +4,052 | 0.01 | 0.01 | +0.00 | buy |
| Pentwater Capital Management LP | 0 | 4,000 | +4,000 | 0.00 | 0.02 | +0.02 | buy |
| NEOS Investment Management LLC | 1,892 | 5,581 | +3,689 | 0.04 | 0.09 | +0.05 | buy |
| Calamos Advisors LLC | 0 | 3,613 | +3,613 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 3,258 | +3,258 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,212 | 122,692 | +2,480 | 0.01 | 0.01 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 2,253 | +2,253 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 2,186 | +2,186 | 0.00 | 0.03 | +0.03 | buy |
| Rockefeller Capital Management L.P. | 33,040 | 35,161 | +2,121 | 0.03 | 0.03 | +0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 2,075 | +2,075 | 0.00 | 0.34 | +0.34 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 2,016 | +2,016 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 21,400 | 23,400 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 1,800 | +1,800 | 0.00 | 0.01 | +0.01 | buy |
| Parkwood LLC | 0 | 1,782 | +1,782 | 0.00 | 0.05 | +0.05 | buy |
| Artia Global Partners LP | 0 | 1,557 | +1,557 | 0.00 | 0.10 | +0.10 | buy |
| China Universal Asset Management Co., Ltd. | 2,292 | 3,801 | +1,509 | 0.10 | 0.13 | +0.03 | buy |
| Allianz Asset Management GmbH | 0 | 1,502 | +1,502 | 0.00 | 0.00 | +0.00 | buy |
| Symmetry Investments LP | 0 | 1,500 | +1,500 | 0.00 | 0.04 | +0.04 | buy |
| Concentric Capital Strategies, LP | 0 | 1,499 | +1,499 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,414 | +1,414 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 1,262 | 2,633 | +1,371 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 1,347 | +1,347 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 1,220 | +1,220 | 0.00 | 0.01 | +0.01 | buy |
| Congress Park Capital LLC | 0 | 1,200 | +1,200 | 0.00 | 0.14 | +0.14 | buy |
| Cerity Partners LLC | 0 | 1,142 | +1,142 | 0.00 | 0.00 | +0.00 | buy |
| Overbrook Management Corp | 0 | 1,130 | +1,130 | 0.00 | 0.08 | +0.08 | buy |
| Qube Research & Technologies Ltd | 33 | 1,158 | +1,125 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 1,431 | 2,534 | +1,103 | 0.12 | 0.24 | +0.12 | buy |
| Walleye Capital LLC | 0 | 1,093 | +1,093 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 1,060 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 2,531 | 3,539 | +1,008 | 0.46 | 0.58 | +0.12 | buy |
| PITCAIRN CO | 0 | 1,007 | +1,007 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 992 | 1,980 | +988 | 0.05 | 0.07 | +0.02 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 973 | +973 | 0.00 | 0.00 | +0.00 | buy |