| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 1,105,741 | 1,775,000 | +669,259 | 23.09 | 32.74 | +9.64 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 388,729 | 803,213 | +414,484 | 0.01 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,902,050 | 2,601,282 | +300,768 | 0.40 | 0.38 | 0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 151,151 | 429,953 | +278,802 | 0.78 | 2.01 | +1.23 | buy |
| ARMISTICE CAPITAL, LLC | 50,000 | 168,000 | +118,000 | 0.16 | 0.59 | +0.44 | buy |
| Artisan Partners Limited Partnership | 296,480 | 401,709 | +105,229 | 0.11 | 0.16 | +0.05 | buy |
| Rock Springs Capital Management LP | 198,169 | 285,931 | +87,762 | 1.13 | 1.94 | +0.81 | buy |
| Avoro Capital Advisors LLC | 1,888,888 | 1,944,444 | +55,556 | 6.04 | 6.06 | +0.02 | buy |
| EMERALD ADVISERS, LLC | 47,722 | 101,623 | +53,901 | 0.47 | 1.09 | +0.62 | buy |
| FRED ALGER MANAGEMENT, LLC | 18,097 | 64,576 | +46,479 | 0.02 | 0.09 | +0.06 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 54,107 | 93,597 | +39,490 | 0.06 | 0.11 | +0.05 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 39,280 | 75,759 | +36,479 | 0.48 | 1.05 | +0.57 | buy |
| TD ASSET MANAGEMENT INC | 15,540 | 50,330 | +34,790 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 5,272 | 35,112 | +29,840 | 0.01 | 0.05 | +0.04 | buy |
| Tri Locum Partners LP | 25,524 | 53,355 | +27,831 | 2.90 | 4.94 | +2.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,873 | 97,752 | +21,879 | 0.01 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 40,910 | 61,399 | +20,489 | 2.21 | 2.64 | +0.42 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 115,000 | +15,000 | 4.61 | 4.99 | +0.38 | buy |
| Rhenman & Partners Asset Management AB | 22,500 | 36,500 | +14,000 | 0.52 | 0.92 | +0.40 | buy |
| Propel Bio Management, LLC | 30,032 | 43,032 | +13,000 | 5.76 | 6.69 | +0.93 | buy |
| Simplify Asset Management Inc. | 14,294 | 23,294 | +9,000 | 0.51 | 0.60 | +0.08 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 18,300 | 23,701 | +5,401 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 26,926 | 32,318 | +5,392 | 0.36 | 0.46 | +0.11 | buy |
| AMI ASSET MANAGEMENT CORP | 4,773 | 9,618 | +4,845 | 0.06 | 0.13 | +0.07 | buy |
| Nan Fung Group Holdings Ltd | 1,182 | 5,682 | +4,500 | 0.17 | 1.41 | +1.24 | buy |
| NEOS Investment Management LLC | 1,892 | 5,581 | +3,689 | 0.04 | 0.09 | +0.05 | buy |
| Rockefeller Capital Management L.P. | 33,040 | 35,161 | +2,121 | 0.03 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,292 | 3,801 | +1,509 | 0.10 | 0.13 | +0.03 | buy |
| PROFUND ADVISORS LLC | 7,160 | 5,763 | +1,397 | 0.07 | 0.06 | 0.00 | sell |
| HighVista Strategies LLC | 1,431 | 2,534 | +1,103 | 0.12 | 0.24 | +0.12 | buy |
| Atle Fund Management AB | 2,531 | 3,539 | +1,008 | 0.46 | 0.58 | +0.12 | buy |
| SHIKIAR ASSET MANAGEMENT INC | 5,000 | 5,400 | +400 | 0.36 | 0.42 | +0.06 | buy |
| ProShare Advisors LLC | 3,711 | 4,054 | +343 | 0.00 | 0.00 | 0.00 | buy |
| Everhart Financial Group, Inc. | 1,143 | 1,378 | +235 | 0.09 | 0.11 | +0.01 | buy |
| Dana Investment Advisors, Inc. | 3,171 | 3,275 | +104 | 0.04 | 0.03 | -0.01 | buy |
| FIL Ltd | 1,391 | 1,493 | +102 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 1,305 | 1,333 | +28 | 0.18 | 0.23 | +0.05 | buy |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 552 | 549 | -3 | 0.02 | 0.02 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 397 | 368 | -29 | 0.06 | 0.05 | -0.01 | sell |
| Ameritas Investment Partners, Inc. | 1,532 | 1,476 | -56 | 0.01 | 0.01 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 1,201 | 1,131 | -70 | 0.12 | 0.12 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 6,644 | 6,163 | -481 | 0.03 | 0.03 | +0.00 | sell |
| E Fund Management Co., Ltd. | 2,306 | 1,698 | -608 | 0.03 | 0.03 | -0.01 | sell |
| FIRST NATIONAL TRUST CO | 4,414 | 3,544 | -870 | 0.04 | 0.04 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3,000 | 2,036 | -964 | 0.06 | 0.04 | -0.02 | sell |
| Verity Asset Management, Inc. | 2,689 | 1,574 | -1,115 | 0.40 | 0.23 | -0.16 | sell |
| Capital Impact Advisors, LLC | 4,992 | 3,726 | -1,266 | 1.52 | 1.29 | -0.22 | sell |
| EULAV Asset Management | 13,000 | 11,000 | -2,000 | 0.09 | 0.08 | -0.01 | sell |
| Knights of Columbus Asset Advisors LLC | 8,695 | 5,163 | -3,532 | 0.13 | 0.10 | -0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 9,223 | 5,124 | -4,099 | 0.38 | 0.23 | -0.15 | sell |
| Exome Asset Management LLC | 13,202 | 7,900 | -5,302 | 3.02 | 1.81 | -1.21 | sell |
| Rafferty Asset Management, LLC | 43,099 | 35,917 | -7,182 | 0.04 | 0.04 | -0.01 | sell |
| GROUPAMA ASSET MANAGMENT | 9,029 | 215 | -8,814 | 0.05 | 0.06 | +0.00 | sell |
| Candriam S.C.A. | 27,000 | 18,000 | -9,000 | 0.04 | 0.03 | -0.01 | sell |
| Knott David M Jr | 14,800 | 3,584 | -11,216 | 1.31 | 0.34 | -0.97 | sell |
| University of Wisconsin Foundation | 73,487 | 56,376 | -17,111 | 28.29 | 16.99 | -11.30 | sell |
| LMR Partners LLP | 51,885 | 22,108 | -29,777 | 0.30 | 0.15 | -0.15 | sell |
| TCG Crossover Management, LLC | 179,917 | 149,283 | -30,634 | 4.62 | 3.15 | -1.47 | sell |
| Erste Asset Management GmbH | 325,000 | 250,625 | -74,375 | 1.10 | 0.91 | -0.20 | sell |
| AlpInvest Partners B.V. | 211,488 | 105,744 | -105,744 | 11.18 | 11.03 | -0.15 | sell |
| Bain Capital Life Sciences Investors, LLC | 324,619 | 196,995 | -127,624 | 7.20 | 4.23 | -2.97 | sell |
| RTW INVESTMENTS, LP | 815,191 | 397,047 | -418,144 | 2.95 | 1.57 | -1.38 | sell |