| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,902,050 | 2,601,282 | -300,768 | 0.40 | 0.38 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 1,969,798 | 1,969,798 | 0 | 5.19 | 6.60 | +1.41 | hold |
| Avoro Capital Advisors LLC | 1,888,888 | 1,944,444 | +55,556 | 6.04 | 6.06 | +0.02 | buy |
| PAULSON & CO. INC. | 1,105,741 | 1,775,000 | +669,259 | 23.09 | 32.74 | +9.64 | buy |
| VANGUARD GROUP INC | 1,574,742 | 1,668,806 | +94,064 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 388,729 | 803,213 | +414,484 | 0.01 | 0.03 | +0.01 | buy |
| FMR LLC | 625,165 | 713,914 | +88,749 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 700,739 | 624,938 | -75,801 | 0.01 | 0.01 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 151,151 | 429,953 | +278,802 | 0.78 | 2.02 | +1.24 | buy |
| Artisan Partners Limited Partnership | 296,480 | 401,709 | +105,229 | 0.11 | 0.16 | +0.05 | buy |
| RTW INVESTMENTS, LP | 815,191 | 397,047 | -418,144 | 2.95 | 1.57 | -1.38 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 336,255 | 346,857 | +10,602 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 151,918 | 288,606 | +136,688 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 198,169 | 285,931 | +87,762 | 1.13 | 1.94 | +0.81 | buy |
| Erste Asset Management GmbH | 325,000 | 250,625 | -74,375 | 1.10 | 0.91 | -0.20 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 204,500 | 204,500 | 0 | 0.74 | 0.69 | -0.04 | hold |
| Bain Capital Life Sciences Investors, LLC | 324,619 | 196,995 | -127,624 | 7.20 | 4.23 | -2.97 | sell |
| Pictet Asset Management Holding SA | 171,165 | 184,163 | +12,998 | 0.04 | 0.05 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 50,000 | 168,000 | +118,000 | 0.31 | 1.19 | +0.89 | buy |
| TCG Crossover Management, LLC | 179,917 | 149,283 | -30,634 | 4.62 | 3.15 | -1.47 | sell |
| NORTHERN TRUST CORP | 134,706 | 131,358 | -3,348 | 0.01 | 0.01 | +0.00 | sell |
| Tao Capital Management LP | 130,529 | 130,529 | 0 | 27.63 | 33.02 | +5.40 | hold |
| UBS Group AG | 88,377 | 125,415 | +37,038 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 125,205 | +125,205 | 0.00 | 0.18 | +0.18 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,212 | 122,692 | +2,480 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 115,000 | +15,000 | 4.61 | 4.99 | +0.38 | buy |
| BANK OF AMERICA CORP /DE/ | 114,904 | 113,114 | -1,790 | 0.00 | 0.00 | +0.00 | sell |
| Artal Group S.A. | 0 | 110,507 | +110,507 | 0.00 | 0.76 | +0.76 | buy |
| Rheos Capital Works Inc. | 0 | 110,215 | +110,215 | 0.00 | 1.41 | +1.41 | buy |
| AlpInvest Partners B.V. | 211,488 | 105,744 | -105,744 | 11.18 | 11.03 | -0.15 | sell |
| EMERALD ADVISERS, LLC | 47,722 | 101,623 | +53,901 | 0.47 | 1.09 | +0.62 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,873 | 97,752 | +21,879 | 0.01 | 0.02 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 97,103 | +97,103 | 0.00 | 0.08 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 54,107 | 93,597 | +39,490 | 0.06 | 0.11 | +0.05 | buy |
| Point72 Asset Management, L.P. | 0 | 93,571 | +93,571 | 0.00 | 0.07 | +0.07 | buy |
| Mirae Asset Global Investments Co., Ltd. | 61,508 | 92,253 | +30,745 | 0.03 | 0.05 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 61,412 | 92,218 | +30,806 | 0.03 | 0.04 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 85,103 | 91,789 | +6,686 | 0.00 | 0.01 | +0.00 | buy |
| NORGES BANK | 145,589 | 89,950 | -55,639 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 8,662 | 80,192 | +71,530 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 39,280 | 75,759 | +36,479 | 0.48 | 1.05 | +0.57 | buy |
| EcoR1 Capital, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.51 | +0.51 | buy |
| FRED ALGER MANAGEMENT, LLC | 18,097 | 64,576 | +46,479 | 0.02 | 0.09 | +0.06 | buy |
| MPM BioImpact LLC | 40,910 | 61,399 | +20,489 | 2.21 | 2.64 | +0.42 | buy |
| MACQUARIE GROUP LTD | 28,500 | 58,957 | +30,457 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 62,178 | 57,883 | -4,295 | 0.00 | 0.00 | +0.00 | sell |
| University of Wisconsin Foundation | 73,487 | 56,376 | -17,111 | 28.29 | 16.99 | -11.30 | sell |
| JPMORGAN CHASE & CO | 59,313 | 55,404 | -3,909 | 0.00 | 0.00 | -0.00 | sell |
| Tri Locum Partners LP | 25,524 | 53,355 | +27,831 | 2.90 | 4.94 | +2.04 | buy |
| Sio Capital Management, LLC | 0 | 51,000 | +51,000 | 0.00 | 4.74 | +4.74 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 50,709 | +50,709 | 0.00 | 0.13 | +0.13 | buy |
| TD ASSET MANAGEMENT INC | 15,540 | 50,330 | +34,790 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 59,397 | 46,546 | -12,851 | 0.01 | 0.01 | -0.00 | sell |
| GROUP ONE TRADING LLC | 191,931 | 43,171 | -148,760 | 1.40 | 0.41 | -0.99 | sell |
| Propel Bio Management, LLC | 30,032 | 43,032 | +13,000 | 5.76 | 6.69 | +0.93 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 42,986 | +42,986 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 39,083 | +39,083 | 0.00 | 0.13 | +0.13 | buy |
| Rokos Capital Management LLP | 0 | 37,762 | +37,762 | 0.00 | 0.26 | +0.26 | buy |
| Rhenman & Partners Asset Management AB | 22,500 | 36,500 | +14,000 | 0.52 | 0.92 | +0.40 | buy |
| Rafferty Asset Management, LLC | 43,099 | 35,917 | -7,182 | 0.04 | 0.04 | -0.01 | sell |
| Rockefeller Capital Management L.P. | 33,040 | 35,161 | +2,121 | 0.03 | 0.03 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 5,272 | 35,112 | +29,840 | 0.01 | 0.05 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 34,219 | +34,219 | 0.00 | 0.10 | +0.10 | buy |
| CITIGROUP INC | 21,323 | 32,790 | +11,467 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 26,926 | 32,318 | +5,392 | 0.36 | 0.46 | +0.11 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,079 | 30,741 | +14,662 | 0.00 | 0.01 | +0.01 | buy |
| Twin Tree Management, LP | 0 | 30,297 | +30,297 | 0.00 | 0.18 | +0.18 | buy |
| CIBC Private Wealth Group LLC | 0 | 30,050 | +30,050 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 0 | 29,973 | +29,973 | 0.00 | 0.40 | +0.40 | buy |
| ALLIANCEBERNSTEIN L.P. | 339,754 | 27,900 | -311,854 | 0.03 | 0.00 | -0.03 | sell |
| BARCLAYS PLC | 38,354 | 25,223 | -13,131 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 216,818 | 25,151 | -191,667 | 0.06 | 0.01 | -0.05 | sell |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.76 | +0.76 | buy |
| CITADEL ADVISORS LLC | 10,492 | 24,612 | +14,120 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 18,300 | 23,701 | +5,401 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 21,400 | 23,400 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 14,294 | 23,294 | +9,000 | 0.51 | 0.60 | +0.08 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,347 | 22,399 | +4,052 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 16,949 | 22,357 | +5,408 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 3,300 | 22,300 | +19,000 | 0.00 | 0.03 | +0.02 | buy |
| LMR Partners LLP | 51,885 | 22,108 | -29,777 | 0.30 | 0.15 | -0.15 | sell |
| RHUMBLINE ADVISERS | 20,624 | 21,142 | +518 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 20,190 | 20,190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 0 | 19,700 | +19,700 | 0.00 | 0.05 | +0.05 | buy |
| Sofinnova Investments, Inc. | 0 | 19,029 | +19,029 | 0.00 | 0.30 | +0.30 | buy |
| Candriam S.C.A. | 27,000 | 18,000 | -9,000 | 0.04 | 0.03 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,003 | 17,527 | +4,524 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,785 | 16,811 | -42,974 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 14,235 | 14,235 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 13,320 | 13,320 | 0 | 0.15 | 0.16 | +0.01 | hold |
| Blue Owl Capital Holdings LP | 0 | 13,319 | +13,319 | 0.00 | 0.71 | +0.71 | buy |
| Assenagon Asset Management S.A. | 19,082 | 12,958 | -6,124 | 0.01 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 21,174 | 12,525 | -8,649 | 0.06 | 0.04 | -0.02 | sell |
| Legal & General Group Plc | 12,254 | 12,496 | +242 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,095 | 12,139 | +44 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 13,106 | 11,988 | -1,118 | 0.01 | 0.01 | -0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 12,803 | 11,839 | -964 | 0.03 | 0.03 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 22,769 | 11,374 | -11,395 | 0.01 | 0.00 | -0.01 | sell |
| Newbridge Financial Services Group, Inc. | 0 | 11,033 | +11,033 | 0.00 | 1.29 | +1.29 | buy |
| EULAV Asset Management | 13,000 | 11,000 | -2,000 | 0.09 | 0.08 | -0.01 | sell |