| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,141,701 | 2,141,701 | 0 | 7.30 | 6.44 | -0.87 | hold |
| JANUS HENDERSON GROUP PLC | 1,584,843 | 2,018,647 | +433,804 | 0.41 | 0.50 | +0.09 | buy |
| RTW INVESTMENTS, LP | 1,993,687 | 1,993,687 | 0 | 11.63 | 10.38 | -1.24 | hold |
| Avoro Capital Advisors LLC | 1,807,500 | 1,818,181 | +10,681 | 10.35 | 9.38 | -0.97 | buy |
| BlackRock, Inc. | 1,644,750 | 1,559,965 | -84,785 | 0.02 | 0.01 | -0.00 | sell |
| PAULSON & CO. INC. | 1,707,522 | 1,392,188 | -315,334 | 30.48 | 23.42 | -7.06 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 461,402 | 694,958 | +233,556 | 0.05 | 0.07 | +0.02 | buy |
| STATE STREET CORP | 583,003 | 609,525 | +26,522 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 439,398 | 511,728 | +72,330 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 451,743 | 455,870 | +4,127 | 0.02 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 36,134 | 453,843 | +417,709 | 0.01 | 0.17 | +0.15 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 354,220 | 340,519 | -13,701 | 0.58 | 0.59 | +0.01 | sell |
| Invesco Ltd. | 365,314 | 329,519 | -35,795 | 0.03 | 0.02 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 313,659 | 328,110 | +14,451 | 0.02 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 270,151 | 289,310 | +19,159 | 0.72 | 0.66 | -0.06 | buy |
| GOLDMAN SACHS GROUP INC | 305,847 | 277,371 | -28,476 | 0.03 | 0.02 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 265,705 | 264,583 | -1,122 | 3.79 | 4.57 | +0.78 | sell |
| Hood River Capital Management LLC | 247,560 | 249,511 | +1,951 | 1.58 | 1.31 | -0.27 | buy |
| LORD, ABBETT & CO. LLC | 244,796 | 242,726 | -2,070 | 0.44 | 0.41 | -0.02 | sell |
| Point72 Asset Management, L.P. | 126,435 | 225,510 | +99,075 | 0.12 | 0.21 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 219,099 | 216,720 | -2,379 | 0.02 | 0.02 | -0.00 | sell |
| MORGAN STANLEY | 150,462 | 191,294 | +40,832 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 416,025 | 189,527 | -226,498 | 0.02 | 0.01 | -0.01 | sell |
| Pictet Asset Management Holding SA | 181,949 | 187,240 | +5,291 | 0.10 | 0.10 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 23,226 | 185,331 | +162,105 | 0.02 | 0.15 | +0.13 | buy |
| Artisan Partners Limited Partnership | 198,693 | 183,540 | -15,153 | 0.18 | 0.16 | -0.02 | sell |
| Fiera Capital Corp | 169,456 | 174,011 | +4,555 | 0.31 | 0.31 | -0.00 | buy |
| Rock Springs Capital Management LP | 139,618 | 170,999 | +31,381 | 4.17 | 5.28 | +1.10 | buy |
| AMERICAN CENTURY COMPANIES INC | 185,116 | 163,933 | -21,183 | 0.05 | 0.04 | -0.01 | sell |
| Erste Asset Management GmbH | 141,100 | 160,210 | +19,110 | 0.69 | 0.75 | +0.06 | buy |
| NORTHERN TRUST CORP | 151,802 | 149,214 | -2,588 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 136,869 | 135,908 | -961 | 0.01 | 0.01 | -0.00 | sell |
| TORONTO DOMINION BANK | 0 | 130,460 | +130,460 | 0.00 | 0.13 | +0.13 | buy |
| Woodline Partners LP | 125,659 | 125,899 | +240 | 0.28 | 0.25 | -0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,912 | 125,447 | +103,535 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 102,641 | 117,779 | +15,138 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 111,666 | 110,960 | -706 | 0.44 | 0.43 | -0.01 | sell |
| Redwood Wealth Management Group, LLC | 108,164 | 107,847 | -317 | 1.26 | 1.29 | +0.03 | sell |
| Tri Locum Partners LP | 86,023 | 103,288 | +17,265 | 6.50 | 7.59 | +1.08 | buy |
| AMERIPRISE FINANCIAL INC | 29,287 | 98,181 | +68,894 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 192,109 | 98,067 | -94,042 | 0.04 | 0.02 | -0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 94,813 | +94,813 | 0.00 | 0.21 | +0.21 | buy |
| Logos Global Management LP | 0 | 85,000 | +85,000 | 0.00 | 2.29 | +2.29 | buy |
| Candriam S.C.A. | 63,906 | 84,948 | +21,042 | 0.19 | 0.23 | +0.05 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 240,000 | 80,000 | -160,000 | 0.61 | 0.19 | -0.42 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,933 | 75,129 | -804 | 0.06 | 0.05 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 86,076 | 74,041 | -12,035 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 83,862 | 71,870 | -11,992 | 0.08 | 0.06 | -0.02 | sell |
| RAYMOND JAMES FINANCIAL INC | 66,724 | 66,529 | -195 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 82,624 | 62,441 | -20,183 | 1.06 | 0.87 | -0.19 | sell |
| Nuveen, LLC | 118,363 | 62,060 | -56,303 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 64,254 | 59,971 | -4,283 | 0.04 | 0.03 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 73,707 | 57,177 | -16,530 | 0.03 | 0.02 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 31,131 | 55,000 | +23,869 | 1.30 | 1.69 | +0.39 | buy |
| Squarepoint Ops LLC | 74,934 | 52,884 | -22,050 | 0.09 | 0.06 | -0.03 | sell |
| EULAV Asset Management | 49,000 | 49,000 | 0 | 0.76 | 0.82 | +0.06 | hold |
| Russell Investments Group, Ltd. | 48,159 | 44,504 | -3,655 | 0.03 | 0.03 | -0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 50,631 | 40,926 | -9,705 | 0.08 | 0.06 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 6,978 | 40,853 | +33,875 | 0.00 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,051 | 39,852 | +10,801 | 0.01 | 0.02 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 38,913 | 37,654 | -1,259 | 0.70 | 0.62 | -0.07 | sell |
| JPMORGAN CHASE & CO | 40,079 | 36,315 | -3,764 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 93,114 | 35,838 | -57,276 | 0.06 | 0.02 | -0.04 | sell |
| GROUPAMA ASSET MANAGMENT | 30,620 | 35,238 | +4,618 | 0.26 | 0.27 | +0.01 | buy |
| PFM Health Sciences, LP | 7,258 | 34,146 | +26,888 | 0.43 | 1.88 | +1.45 | buy |
| Rockefeller Capital Management L.P. | 19,661 | 33,849 | +14,188 | 0.02 | 0.03 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 15,347 | 32,879 | +17,532 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 43,457 | 32,212 | -11,245 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 33,520 | 31,870 | -1,650 | 0.26 | 0.17 | -0.09 | sell |
| Vestal Point Capital, LP | 0 | 31,468 | +31,468 | 0.00 | 0.46 | +0.46 | buy |
| D. E. Shaw & Co., Inc. | 88,554 | 30,139 | -58,415 | 0.04 | 0.01 | -0.03 | sell |
| GILDER GAGNON HOWE & CO LLC | 33,468 | 29,391 | -4,077 | 0.21 | 0.18 | -0.02 | sell |
| Swiss National Bank | 28,580 | 29,220 | +640 | 0.01 | 0.01 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 58,295 | 27,937 | -30,358 | 0.09 | 0.03 | -0.06 | sell |
| CITIGROUP INC | 23,327 | 25,589 | +2,262 | 0.01 | 0.01 | -0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.69 | +0.69 | buy |
| Clearbridge Investments, LLC | 0 | 24,447 | +24,447 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 23,076 | 24,198 | +1,122 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 19,550 | 24,050 | +4,500 | 1.06 | 1.55 | +0.49 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,846 | 23,796 | -50 | 0.00 | 0.00 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 17,254 | 23,560 | +6,306 | 0.02 | 0.03 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 31,286 | 23,198 | -8,088 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 24,819 | 22,233 | -2,586 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,466 | 22,216 | -42,250 | 0.05 | 0.02 | -0.04 | sell |
| MARSHALL WACE, LLP | 39,578 | 21,902 | -17,676 | 0.02 | 0.01 | -0.01 | sell |
| RHUMBLINE ADVISERS | 23,691 | 21,764 | -1,927 | 0.01 | 0.01 | -0.00 | sell |
| Tao Capital Management LP | 21,000 | 21,000 | 0 | 10.53 | 9.25 | -1.27 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 19,076 | 18,452 | -624 | 0.02 | 0.02 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,008 | 17,047 | +3,039 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 16,325 | 16,903 | +578 | 0.02 | 0.01 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 24,996 | 16,500 | -8,496 | 0.71 | 0.42 | -0.29 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,052 | 16,300 | +248 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 5,390 | 16,033 | +10,643 | 0.00 | 0.01 | +0.01 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 15,963 | +15,963 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,006 | 15,953 | +5,947 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 15,372 | 15,461 | +89 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 3,687 | 15,326 | +11,639 | 0.12 | 0.53 | +0.40 | buy |
| HighTower Advisors, LLC | 1,173 | 13,914 | +12,741 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 9,276 | 13,432 | +4,156 | 0.01 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 69 | 13,227 | +13,158 | 0.00 | 0.04 | +0.04 | buy |