| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 397,047 | 1,915,862 | +1,518,815 | 1.57 | 8.31 | +6.74 | buy |
| ArrowMark Colorado Holdings LLC | 34,219 | 187,393 | +153,174 | 0.10 | 0.63 | +0.52 | buy |
| Woodline Partners LP | 19,700 | 138,309 | +118,609 | 0.05 | 0.37 | +0.32 | buy |
| JANUS HENDERSON GROUP PLC | 2,601,282 | 2,485,751 | +115,531 | 0.38 | 0.38 | 0.00 | sell |
| Avoro Capital Advisors LLC | 1,944,444 | 2,055,555 | +111,111 | 6.06 | 7.67 | +1.61 | buy |
| PAULSON & CO. INC. | 1,775,000 | 1,850,000 | +75,000 | 32.74 | 38.31 | +5.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,213 | 858,765 | +55,552 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 346,857 | 399,854 | +52,997 | 0.01 | 0.01 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 64,576 | 102,455 | +37,879 | 0.09 | 0.14 | +0.05 | buy |
| Sofinnova Investments, Inc. | 19,029 | 44,417 | +25,388 | 0.28 | 0.65 | +0.36 | buy |
| Rockefeller Capital Management L.P. | 35,161 | 19,088 | +16,073 | 0.03 | 0.02 | 0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 97,752 | 111,113 | +13,361 | 0.02 | 0.02 | +0.00 | buy |
| Tri Locum Partners LP | 53,355 | 65,352 | +11,997 | 4.94 | 4.63 | -0.31 | buy |
| GROUPAMA ASSET MANAGMENT | 215 | 11,874 | +11,659 | 0.06 | 0.05 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 23,701 | 12,708 | +10,993 | 0.01 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 93,597 | 83,062 | +10,535 | 0.11 | 0.10 | -0.01 | sell |
| MPM BioImpact LLC | 61,399 | 71,185 | +9,786 | 2.64 | 3.10 | +0.46 | buy |
| TD ASSET MANAGEMENT INC | 50,330 | 55,730 | +5,400 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,969,798 | 1,974,590 | +4,792 | 6.60 | 7.07 | +0.47 | buy |
| Concentric Capital Strategies, LP | 1,499 | 4,828 | +3,329 | 0.03 | 0.08 | +0.06 | buy |
| Exome Asset Management LLC | 7,900 | 10,800 | +2,900 | 1.81 | 2.69 | +0.89 | buy |
| PROFUND ADVISORS LLC | 5,763 | 6,816 | +1,053 | 0.06 | 0.07 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 368 | 1,189 | +821 | 0.05 | 0.16 | +0.11 | buy |
| ProShare Advisors LLC | 4,054 | 3,298 | +756 | 0.00 | 0.00 | 0.00 | sell |
| E Fund Management Co., Ltd. | 1,698 | 2,212 | +514 | 0.03 | 0.03 | +0.01 | buy |
| Rafferty Asset Management, LLC | 35,917 | 36,418 | +501 | 0.04 | 0.04 | +0.00 | buy |
| Calamos Advisors LLC | 3,613 | 4,112 | +499 | 0.00 | 0.01 | +0.00 | buy |
| Parkwood LLC | 1,782 | 2,264 | +482 | 0.04 | 0.08 | +0.04 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 2,036 | 2,500 | +464 | 0.04 | 0.06 | +0.02 | buy |
| Dana Investment Advisors, Inc. | 3,275 | 3,713 | +438 | 0.03 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 1,476 | 1,719 | +243 | 0.01 | 0.02 | +0.00 | buy |
| FIL Ltd | 1,493 | 1,606 | +113 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 125,205 | 125,300 | +95 | 0.18 | 0.21 | +0.03 | buy |
| PITCAIRN CO | 1,007 | 1,091 | +84 | 0.02 | 0.02 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 5,163 | 5,246 | +83 | 0.10 | 0.10 | -0.00 | buy |
| Bellevue Group AG | 1,060 | 1,100 | +40 | 0.00 | 0.01 | +0.00 | buy |
| Everhart Financial Group, Inc. | 1,378 | 1,403 | +25 | 0.11 | 0.10 | -0.01 | buy |
| Compagnie Lombard Odier SCmA | 80 | 104 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 23,294 | 23,313 | +19 | 0.60 | 0.57 | -0.02 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 13,320 | 13,325 | +5 | 0.16 | 0.16 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 30,050 | 30,051 | +1 | 0.02 | 0.02 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,131 | 1,065 | -66 | 0.12 | 0.12 | +0.00 | sell |
| CASTLEARK MANAGEMENT LLC | 9,210 | 9,130 | -80 | 0.10 | 0.10 | +0.00 | sell |
| INVESTORS ASSET MANAGEMENT OF GEORGIA INC /GA/ /ADV | 875 | 725 | -150 | 0.11 | 0.10 | -0.01 | sell |
| New Harbor Financial Group, LLC | 911 | 718 | -193 | 0.08 | 0.06 | -0.02 | sell |
| Verity Asset Management, Inc. | 1,574 | 1,365 | -209 | 0.23 | 0.15 | -0.08 | sell |
| MOODY ALDRICH PARTNERS LLC | 5,124 | 4,814 | -310 | 0.23 | 0.26 | +0.03 | sell |
| GILDER GAGNON HOWE & CO LLC | 39,083 | 38,377 | -706 | 0.13 | 0.13 | +0.00 | sell |
| NEOS Investment Management LLC | 5,581 | 4,598 | -983 | 0.09 | 0.05 | -0.04 | sell |
| EULAV Asset Management | 11,000 | 10,000 | -1,000 | 0.08 | 0.08 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 3,801 | 2,504 | -1,297 | 0.13 | 0.10 | -0.03 | sell |
| AMI ASSET MANAGEMENT CORP | 9,618 | 5,485 | -4,133 | 0.13 | 0.08 | -0.05 | sell |
| EMERALD ADVISERS, LLC | 101,623 | 96,764 | -4,859 | 1.09 | 1.14 | +0.04 | sell |
| Affinity Asset Advisors, LLC | 115,000 | 110,000 | -5,000 | 3.80 | 3.55 | -0.25 | sell |
| Erste Asset Management GmbH | 250,625 | 245,380 | -5,245 | 0.91 | 0.91 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 36,500 | 26,500 | -10,000 | 0.92 | 0.71 | -0.21 | sell |
| University of Wisconsin Foundation | 56,376 | 45,730 | -10,646 | 16.99 | 14.42 | -2.56 | sell |
| Hennion & Walsh Asset Management, Inc. | 32,318 | 20,337 | -11,981 | 0.46 | 0.29 | -0.17 | sell |
| Rokos Capital Management LLP | 37,762 | 23,649 | -14,113 | 0.05 | 0.04 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 42,986 | 25,644 | -17,342 | 0.01 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 168,000 | 150,000 | -18,000 | 0.59 | 0.53 | -0.07 | sell |
| AlpInvest Partners B.V. | 105,744 | 84,595 | -21,149 | 11.03 | 8.50 | -2.53 | sell |
| Rock Springs Capital Management LP | 285,931 | 245,499 | -40,432 | 1.94 | 2.07 | +0.13 | sell |
| Artisan Partners Limited Partnership | 401,709 | 345,085 | -56,624 | 0.16 | 0.14 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 429,953 | 264,600 | -165,353 | 2.01 | 1.79 | -0.22 | sell |