| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 397,047 | 1,915,862 | +1,518,815 | 1.57 | 8.31 | +6.74 | buy |
| ArrowMark Colorado Holdings LLC | 34,219 | 187,393 | +153,174 | 0.10 | 0.63 | +0.52 | buy |
| VANGUARD GROUP INC | 1,668,806 | 1,806,704 | +137,898 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 113,114 | 239,554 | +126,440 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 624,938 | 744,714 | +119,776 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 19,700 | 138,309 | +118,609 | 0.05 | 0.37 | +0.32 | buy |
| Fiera Capital Corp | 0 | 115,415 | +115,415 | 0.00 | 0.10 | +0.10 | buy |
| Avoro Capital Advisors LLC | 1,944,444 | 2,055,555 | +111,111 | 6.06 | 7.67 | +1.61 | buy |
| GOLDMAN SACHS GROUP INC | 91,789 | 171,451 | +79,662 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 713,914 | 789,003 | +75,089 | 0.01 | 0.01 | +0.00 | buy |
| PAULSON & CO. INC. | 1,775,000 | 1,850,000 | +75,000 | 32.74 | 38.31 | +5.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,213 | 858,765 | +55,552 | 0.03 | 0.03 | +0.00 | buy |
| Invesco Ltd. | 80,192 | 133,758 | +53,566 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 346,857 | 399,854 | +52,997 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 125,415 | 173,240 | +47,825 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 64,576 | 102,455 | +37,879 | 0.09 | 0.14 | +0.05 | buy |
| GROUP ONE TRADING LLC | 43,171 | 76,399 | +33,228 | 0.41 | 0.67 | +0.26 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,399 | 51,173 | +28,774 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,527 | 44,287 | +26,760 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 89,950 | 116,027 | +26,077 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 19,029 | 44,417 | +25,388 | 0.30 | 0.78 | +0.48 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 24,460 | +24,460 | 0.00 | 0.05 | +0.05 | buy |
| ORG Partners LLC | 0 | 22,393 | +22,393 | 0.00 | 0.07 | +0.07 | buy |
| RiverFront Investment Group, LLC | 0 | 21,100 | +21,100 | 0.00 | 0.00 | +0.00 | buy |
| RiverFront Investment Group, LLC | 0 | 21,100 | +21,100 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,900 | 44,570 | +16,670 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 57,883 | 73,815 | +15,932 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 122,692 | 138,314 | +15,622 | 0.01 | 0.01 | -0.00 | buy |
| Atlas Wealth LLC | 0 | 14,511 | +14,511 | 0.00 | 0.05 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 97,752 | 111,113 | +13,361 | 0.02 | 0.02 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,811 | 29,635 | +12,824 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 53,355 | 65,352 | +11,997 | 4.94 | 4.63 | -0.31 | buy |
| GROUPAMA ASSET MANAGMENT | 215 | 11,874 | +11,659 | 0.06 | 0.05 | -0.01 | buy |
| JANE STREET GROUP, LLC | 25,151 | 36,204 | +11,053 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 14,235 | 24,609 | +10,374 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 61,399 | 71,185 | +9,786 | 2.64 | 3.10 | +0.46 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 4,838 | 14,454 | +9,616 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 22,300 | 31,600 | +9,300 | 0.03 | 0.04 | +0.01 | buy |
| ROYAL BANK OF CANADA | 2,511 | 8,375 | +5,864 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 50,330 | 55,730 | +5,400 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 5,170 | +5,170 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,741 | 35,678 | +4,937 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,969,798 | 1,974,590 | +4,792 | 6.60 | 7.07 | +0.47 | buy |
| WOLVERINE TRADING, LLC | 0 | 4,582 | +4,582 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 21,142 | 25,351 | +4,209 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,488 | 9,302 | +3,814 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 3,639 | +3,639 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 3,477 | +3,477 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 3,409 | +3,409 | 0.00 | 0.11 | +0.11 | buy |
| Concentric Capital Strategies, LP | 1,499 | 4,828 | +3,329 | 0.03 | 0.08 | +0.06 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 12,525 | 15,762 | +3,237 | 0.04 | 0.05 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 593 | 3,572 | +2,979 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 0 | 2,968 | +2,968 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 7,900 | 10,800 | +2,900 | 1.81 | 2.69 | +0.89 | buy |
| MetLife Investment Management, LLC | 7,586 | 10,123 | +2,537 | 0.01 | 0.02 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,448 | +2,448 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 20,190 | 22,262 | +2,072 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 800 | 2,600 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 3,429 | 5,178 | +1,749 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 915 | 2,655 | +1,740 | 0.01 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,577 | 5,067 | +1,490 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 1,476 | +1,476 | 0.00 | 0.01 | +0.01 | buy |
| Snowden Capital Advisors LLC | 0 | 1,462 | +1,462 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 23,400 | 24,800 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 1,269 | +1,269 | 0.00 | 0.01 | +0.01 | buy |
| INCEPTIONR LLC | 0 | 1,159 | +1,159 | 0.00 | 0.09 | +0.09 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 954 | 2,068 | +1,114 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 5,763 | 6,816 | +1,053 | 0.06 | 0.07 | +0.01 | buy |
| TORNO CAPITAL, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.03 | +0.03 | buy |
| Focus Partners Wealth | 0 | 970 | +970 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 2,277 | 3,212 | +935 | 0.00 | 0.00 | +0.00 | buy |
| Dorsey & Whitney Trust CO LLC | 0 | 934 | +934 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 12,496 | 13,430 | +934 | 0.00 | 0.00 | +0.00 | buy |
| Envestnet Portfolio Solutions, Inc. | 0 | 898 | +898 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 0 | 893 | +893 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 892 | +892 | 0.00 | 0.06 | +0.06 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 862 | +862 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 368 | 1,189 | +821 | 0.05 | 0.16 | +0.11 | buy |
| TRUIST FINANCIAL CORP | 0 | 772 | +772 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 728 | +728 | 0.00 | 0.00 | +0.00 | buy |
| D.A. DAVIDSON & CO. | 0 | 715 | +715 | 0.00 | 0.00 | +0.00 | buy |
| CENTAURUS FINANCIAL, INC. | 0 | 583 | +583 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,139 | 12,659 | +520 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 1,698 | 2,212 | +514 | 0.03 | 0.03 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,577 | 9,087 | +510 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 35,917 | 36,418 | +501 | 0.04 | 0.04 | +0.00 | buy |
| Calamos Advisors LLC | 3,613 | 4,112 | +499 | 0.00 | 0.01 | +0.00 | buy |
| Parkwood LLC | 1,782 | 2,264 | +482 | 0.05 | 0.08 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 2,036 | 2,500 | +464 | 0.04 | 0.06 | +0.02 | buy |
| Dana Investment Advisors, Inc. | 3,275 | 3,713 | +438 | 0.03 | 0.04 | +0.01 | buy |
| HighTower Advisors, LLC | 1,390 | 1,784 | +394 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,057 | 2,444 | +387 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 2,970 | 3,335 | +365 | 0.01 | 0.01 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 341 | +341 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 335 | +335 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 982 | 1,289 | +307 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 3,255 | 3,525 | +270 | 0.01 | 0.01 | +0.00 | buy |
| Mariner, LLC | 2,633 | 2,888 | +255 | 0.00 | 0.00 | +0.00 | buy |