| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,141,701 | 2,143,131 | +1,430 | 6.44 | 5.77 | -0.67 | buy |
| RTW INVESTMENTS, LP | 1,993,687 | 1,993,687 | 0 | 10.38 | 9.14 | -1.25 | hold |
| Avoro Capital Advisors LLC | 1,818,181 | 1,833,333 | +15,152 | 9.38 | 8.84 | -0.54 | buy |
| PAULSON & CO. INC. | 1,392,188 | 1,340,020 | -52,168 | 23.42 | 27.94 | +4.51 | sell |
| BlackRock, Inc. | 1,559,965 | 1,200,770 | -359,195 | 0.01 | 0.01 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 694,958 | 825,714 | +130,756 | 0.07 | 0.08 | +0.01 | buy |
| STATE STREET CORP | 609,525 | 527,057 | -82,468 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 453,843 | 507,233 | +53,390 | 0.17 | 0.16 | -0.01 | buy |
| UBS Group AG | 117,779 | 401,708 | +283,929 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 455,870 | 374,880 | -80,990 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 511,728 | 356,201 | -155,527 | 0.01 | 0.01 | -0.01 | sell |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 340,519 | 324,123 | -16,396 | 0.59 | 0.52 | -0.07 | sell |
| Invesco Ltd. | 329,519 | 301,435 | -28,084 | 0.02 | 0.01 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 264,583 | 288,000 | +23,417 | 4.57 | 4.28 | -0.29 | buy |
| LORD, ABBETT & CO. LLC | 242,726 | 281,500 | +38,774 | 0.41 | 0.43 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 277,371 | 246,280 | -31,091 | 0.02 | 0.01 | -0.01 | sell |
| Polar Capital Holdings Plc | 289,310 | 244,274 | -45,036 | 0.66 | 0.37 | -0.29 | sell |
| AMERIPRISE FINANCIAL INC | 98,181 | 231,205 | +133,024 | 0.01 | 0.03 | +0.01 | buy |
| NORGES BANK | 0 | 213,886 | +213,886 | 0.00 | 0.01 | +0.01 | buy |
| Artisan Partners Limited Partnership | 183,540 | 210,205 | +26,665 | 0.16 | 0.18 | +0.03 | buy |
| Pictet Asset Management Holding SA | 187,240 | 192,896 | +5,656 | 0.10 | 0.10 | -0.00 | buy |
| JANE STREET GROUP, LLC | 35,838 | 191,541 | +155,703 | 0.02 | 0.07 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 125,447 | 189,458 | +64,011 | 0.02 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 328,110 | 187,226 | -140,884 | 0.02 | 0.01 | -0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 184,324 | +184,324 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 216,720 | 184,324 | -32,396 | 0.02 | 0.01 | -0.00 | sell |
| TORONTO DOMINION BANK | 130,460 | 181,432 | +50,972 | 0.13 | 0.16 | +0.03 | buy |
| Rock Springs Capital Management LP | 170,999 | 174,999 | +4,000 | 5.28 | 4.59 | -0.69 | buy |
| Hood River Capital Management LLC | 249,511 | 169,084 | -80,427 | 1.31 | 0.66 | -0.65 | sell |
| Holocene Advisors, LP | 0 | 152,924 | +152,924 | 0.00 | 0.19 | +0.19 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22,216 | 148,610 | +126,394 | 0.02 | 0.07 | +0.06 | buy |
| MORGAN STANLEY | 191,294 | 139,009 | -52,285 | 0.01 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 225,510 | 137,029 | -88,481 | 0.21 | 0.11 | -0.09 | sell |
| BANK OF AMERICA CORP /DE/ | 189,527 | 134,036 | -55,491 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 135,908 | 128,520 | -7,388 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 125,899 | 125,899 | 0 | 0.25 | 0.21 | -0.04 | hold |
| Assenagon Asset Management S.A. | 16,033 | 124,214 | +108,181 | 0.01 | 0.09 | +0.07 | buy |
| Erste Asset Management GmbH | 160,210 | 110,210 | -50,000 | 0.75 | 0.45 | -0.30 | sell |
| Clearbridge Investments, LLC | 24,447 | 109,325 | +84,878 | 0.01 | 0.05 | +0.04 | buy |
| MARSHALL WACE, LLP | 21,902 | 101,859 | +79,957 | 0.01 | 0.05 | +0.03 | buy |
| Fiera Capital Corp | 174,011 | 99,857 | -74,154 | 0.31 | 0.19 | -0.12 | sell |
| AMERICAN CENTURY COMPANIES INC | 163,933 | 99,396 | -64,537 | 0.04 | 0.02 | -0.02 | sell |
| NORTHERN TRUST CORP | 149,214 | 98,510 | -50,704 | 0.01 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 75,129 | 94,743 | +19,614 | 0.05 | 0.06 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 94,813 | 93,931 | -882 | 0.21 | 0.16 | -0.04 | sell |
| HRT FINANCIAL LP | 0 | 84,634 | +84,634 | 0.00 | 0.08 | +0.08 | buy |
| DEUTSCHE BANK AG\ | 98,067 | 83,916 | -14,151 | 0.02 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 40,853 | 81,196 | +40,343 | 0.02 | 0.03 | +0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 80,000 | 80,000 | 0 | 0.19 | 0.17 | -0.02 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 79,011 | +79,011 | 0.00 | 0.08 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 110,960 | 78,094 | -32,866 | 0.43 | 0.24 | -0.18 | sell |
| Candriam S.C.A. | 84,948 | 72,121 | -12,827 | 0.23 | 0.17 | -0.06 | sell |
| Tri Locum Partners LP | 103,288 | 68,273 | -35,015 | 7.59 | 4.51 | -3.08 | sell |
| Allspring Global Investments Holdings, LLC | 1,198 | 67,668 | +66,470 | 0.00 | 0.05 | +0.05 | buy |
| Vestal Point Capital, LP | 31,468 | 65,000 | +33,532 | 0.46 | 0.82 | +0.36 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 59,971 | 61,202 | +1,231 | 0.03 | 0.03 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 57,177 | 57,998 | +821 | 0.02 | 0.02 | -0.00 | buy |
| EULAV Asset Management | 49,000 | 52,000 | +3,000 | 0.82 | 0.89 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39,852 | 51,630 | +11,778 | 0.02 | 0.02 | +0.00 | buy |
| Russell Investments Group, Ltd. | 44,504 | 49,189 | +4,685 | 0.03 | 0.02 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 71,870 | 45,942 | -25,928 | 0.06 | 0.03 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 55,000 | 40,000 | -15,000 | 1.69 | 1.05 | -0.64 | sell |
| CITIGROUP INC | 25,589 | 37,255 | +11,666 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 30,139 | 35,071 | +4,932 | 0.01 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 40,926 | 33,420 | -7,506 | 0.06 | 0.03 | -0.03 | sell |
| Nuveen, LLC | 62,060 | 32,631 | -29,429 | 0.01 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 31,870 | 32,444 | +574 | 0.17 | 0.21 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,796 | 32,403 | +8,607 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 32,879 | 31,998 | -881 | 0.02 | 0.02 | -0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 35,238 | 30,941 | -4,297 | 0.27 | 0.21 | -0.06 | sell |
| Swiss National Bank | 29,220 | 29,940 | +720 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 36,315 | 29,473 | -6,842 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 34,146 | 29,313 | -4,833 | 1.88 | 1.37 | -0.51 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,260 | 29,080 | +16,820 | 0.00 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 33,849 | 29,015 | -4,834 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 29,391 | 28,573 | -818 | 0.18 | 0.16 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 32,212 | 26,536 | -5,676 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 24,198 | 25,826 | +1,628 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 25,000 | 25,000 | 0 | 0.69 | 0.55 | -0.14 | hold |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 23,198 | 24,277 | +1,079 | 0.01 | 0.01 | -0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 23,560 | 22,985 | -575 | 0.03 | 0.02 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 6,250 | 22,003 | +15,753 | 0.05 | 0.19 | +0.14 | buy |
| Tao Capital Management LP | 21,000 | 21,000 | 0 | 9.25 | 0.58 | -8.67 | hold |
| HSBC HOLDINGS PLC | 1,101 | 20,240 | +19,139 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 22,233 | 19,826 | -2,407 | 0.01 | 0.01 | -0.00 | sell |
| Weiss Asset Management LP | 0 | 19,325 | +19,325 | 0.00 | 0.12 | +0.12 | buy |
| RAYMOND JAMES FINANCIAL INC | 66,529 | 19,305 | -47,224 | 0.01 | 0.00 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 62,441 | 18,624 | -43,817 | 0.87 | 0.42 | -0.45 | sell |
| RHUMBLINE ADVISERS | 21,764 | 18,154 | -3,610 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 9,040 | 17,419 | +8,379 | 0.81 | 1.34 | +0.52 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,047 | 17,197 | +150 | 0.01 | 0.01 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,953 | 15,827 | -126 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 15,963 | 15,655 | -308 | 0.06 | 0.06 | -0.01 | sell |
| SHIKIAR ASSET MANAGEMENT INC | 4,000 | 14,950 | +10,950 | 0.60 | 2.03 | +1.42 | buy |
| FEDERATED HERMES, INC. | 16,903 | 14,914 | -1,989 | 0.01 | 0.01 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 15,461 | 14,263 | -1,198 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 18,452 | 14,263 | -4,189 | 0.02 | 0.01 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 4,673 | 13,997 | +9,324 | 0.00 | 0.01 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 613 | 13,561 | +12,948 | 0.05 | 0.41 | +0.35 | buy |
| Rheos Capital Works Inc. | 13,215 | 13,215 | 0 | 0.46 | 0.40 | -0.06 | hold |