| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,484,126 | 3,042,661 | +1,558,535 | 0.22 | 0.29 | 0.00 | buy |
| Erste Asset Management GmbH | 11,000 | 250,400 | +239,400 | 0.04 | 0.63 | +0.59 | buy |
| PAULSON & CO. INC. | 350,200 | 500,000 | +149,800 | 7.90 | 6.53 | -1.36 | buy |
| RTW INVESTMENTS, LP | 221,562 | 309,485 | +87,923 | 0.97 | 0.95 | -0.02 | buy |
| Artisan Partners Limited Partnership | 230,090 | 280,090 | +50,000 | 0.09 | 0.07 | -0.02 | buy |
| Avoro Capital Advisors LLC | 1,515,151 | 1,555,000 | +39,849 | 4.75 | 3.54 | -1.21 | buy |
| TCG Crossover Management, LLC | 149,917 | 179,917 | +30,000 | 5.68 | 3.87 | -1.81 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 25,000 | 50,867 | +25,867 | 1.24 | 1.78 | +0.55 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 65,761 | 51,686 | +14,075 | 0.08 | 0.04 | -0.04 | sell |
| Rafferty Asset Management, LLC | 31,256 | 45,323 | +14,067 | 0.04 | 0.04 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 78,682 | 68,082 | +10,600 | 0.03 | 0.02 | -0.01 | sell |
| Tri Locum Partners LP | 26,010 | 33,761 | +7,751 | 2.24 | 1.58 | -0.65 | buy |
| Rockefeller Capital Management L.P. | 11,825 | 18,114 | +6,289 | 0.01 | 0.01 | 0.00 | buy |
| Nebula Research & Development LLC | 2,470 | 6,552 | +4,082 | 0.43 | 0.50 | +0.07 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 4,288 | 7,718 | +3,430 | 0.07 | 0.08 | +0.02 | buy |
| MPM BioImpact LLC | 38,011 | 40,859 | +2,848 | 1.77 | 1.59 | -0.18 | buy |
| L1 Capital Pty Ltd | 45,739 | 48,469 | +2,730 | 1.27 | 0.60 | -0.67 | buy |
| MOODY ALDRICH PARTNERS LLC | 10,926 | 13,579 | +2,653 | 0.49 | 0.38 | -0.11 | buy |
| SECTORAL ASSET MANAGEMENT INC | 18,985 | 20,901 | +1,916 | 0.73 | 0.59 | -0.14 | buy |
| PROFUND ADVISORS LLC | 5,825 | 7,723 | +1,898 | 0.07 | 0.06 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 4,232 | 5,983 | +1,751 | 0.02 | 0.02 | -0.00 | buy |
| Knott David M Jr | 14,000 | 15,000 | +1,000 | 1.29 | 0.84 | -0.45 | buy |
| Verity Asset Management, Inc. | 1,966 | 2,687 | +721 | 0.34 | 0.29 | -0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 1,341 | 2,019 | +678 | 0.03 | 0.03 | +0.00 | buy |
| E Fund Management Co., Ltd. | 1,683 | 2,327 | +644 | 0.03 | 0.03 | -0.00 | buy |
| MBB PUBLIC MARKETS I LLC | 5,490 | 5,990 | +500 | 0.07 | 0.06 | -0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 19,408 | 19,864 | +456 | 0.02 | 0.02 | -0.01 | buy |
| HighVista Strategies LLC | 2,796 | 3,045 | +249 | 0.30 | 0.21 | -0.09 | buy |
| China Universal Asset Management Co., Ltd. | 240 | 468 | +228 | 0.02 | 0.02 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 60 | 194 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 4,235 | 4,309 | +74 | 0.09 | 0.06 | -0.03 | buy |
| ProShare Advisors LLC | 2,955 | 2,977 | +22 | 0.00 | 0.00 | 0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 13,351 | 13,320 | -31 | 0.14 | 0.09 | -0.05 | sell |
| VIRTUS ADVISERS, LLC | 424 | 388 | -36 | 0.06 | 0.03 | -0.02 | sell |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 649 | 518 | -131 | 0.02 | 0.01 | -0.01 | sell |
| Edgestream Partners, L.P. | 2,570 | 1,567 | -1,003 | 0.05 | 0.02 | -0.04 | sell |
| SHIKIAR ASSET MANAGEMENT INC | 6,500 | 5,000 | -1,500 | 0.48 | 0.25 | -0.23 | sell |
| Hennion & Walsh Asset Management, Inc. | 37,594 | 35,972 | -1,622 | 0.51 | 0.33 | -0.18 | sell |
| Inspire Advisors, LLC | 3,288 | 1,579 | -1,709 | 0.15 | 0.04 | -0.11 | sell |
| Rock Springs Capital Management LP | 199,218 | 196,369 | -2,849 | 1.09 | 0.77 | -0.33 | sell |
| Atlas Wealth LLC | 16,004 | 13,095 | -2,909 | 0.07 | 0.05 | -0.02 | sell |
| Polar Asset Management Partners Inc. | 15,700 | 10,300 | -5,400 | 0.07 | 0.04 | -0.04 | sell |
| Affinity Asset Advisors, LLC | 92,500 | 85,000 | -7,500 | 8.41 | 4.06 | -4.35 | sell |
| ARMISTICE CAPITAL, LLC | 136,000 | 108,000 | -28,000 | 0.79 | 0.47 | -0.32 | sell |
| EMERALD ADVISERS, LLC | 61,483 | 878 | -60,605 | 0.62 | 0.01 | -0.62 | sell |
| ORBIMED ADVISORS LLC | 321,569 | 253,309 | -68,260 | 1.36 | 0.79 | -0.56 | sell |
| PERCEPTIVE ADVISORS LLC | 302,987 | 124,637 | -178,350 | 2.03 | 0.61 | -1.42 | sell |