| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 1,850,000 | 2,042,000 | +192,000 | 38.31 | 27.55 | -10.76 | buy |
| BRAIDWELL LP | 0 | 183,818 | +183,818 | 0.00 | 1.11 | +1.11 | buy |
| STATE STREET CORP | 744,714 | 887,752 | +143,038 | 0.01 | 0.01 | -0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 111,144 | +111,144 | 0.00 | 1.41 | +1.41 | buy |
| MARSHALL WACE, LLP | 1,700 | 80,401 | +78,701 | 0.00 | 0.02 | +0.02 | buy |
| RTW INVESTMENTS, LP | 1,915,862 | 1,993,687 | +77,825 | 8.31 | 6.12 | -2.19 | buy |
| GOLDMAN SACHS GROUP INC | 171,451 | 239,780 | +68,329 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 220,031 | 269,394 | +49,363 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 76,399 | 123,425 | +47,026 | 0.67 | 1.04 | +0.36 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 44,497 | +44,497 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 11,190 | 54,649 | +43,459 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 1,511 | 37,660 | +36,149 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 30,000 | +30,000 | 0.00 | 0.50 | +0.50 | buy |
| VANGUARD GROUP INC | 1,806,704 | 1,833,768 | +27,064 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 15,196 | 40,279 | +25,083 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 24,460 | 46,094 | +21,634 | 0.05 | 0.08 | +0.03 | buy |
| JPMORGAN CHASE & CO | 52,656 | 70,778 | +18,122 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 245,499 | 263,062 | +17,563 | 2.08 | 1.82 | -0.26 | buy |
| NORTHERN TRUST CORP | 131,445 | 147,772 | +16,327 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4,814 | 18,207 | +13,393 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 137,275 | 150,598 | +13,323 | 0.04 | 0.04 | -0.01 | buy |
| CITIGROUP INC | 16,062 | 28,621 | +12,559 | 0.00 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 0 | 12,300 | +12,300 | 0.00 | 0.28 | +0.28 | buy |
| HRT FINANCIAL LP | 0 | 10,088 | +10,088 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,314 | 147,970 | +9,656 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 9,031 | +9,031 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 8,930 | +8,930 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 138,309 | 147,090 | +8,781 | 0.37 | 0.26 | -0.11 | buy |
| Rafferty Asset Management, LLC | 36,418 | 44,624 | +8,206 | 0.04 | 0.03 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 12,708 | 20,842 | +8,134 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 173,240 | 180,630 | +7,390 | 0.01 | 0.01 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 6,428 | +6,428 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 6,032 | +6,032 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 399,854 | 405,655 | +5,801 | 0.01 | 0.01 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 5,764 | +5,764 | 0.00 | 0.03 | +0.03 | buy |
| Cinctive Capital Management LP | 0 | 5,074 | +5,074 | 0.00 | 0.06 | +0.06 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,954 | 14,024 | +5,070 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 5,025 | +5,025 | 0.00 | 0.10 | +0.10 | buy |
| XTX Topco Ltd | 0 | 4,881 | +4,881 | 0.00 | 0.08 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,956 | 9,767 | +4,811 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 1,585 | 6,176 | +4,591 | 0.01 | 0.03 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 5,682 | 9,762 | +4,080 | 1.70 | 1.78 | +0.09 | buy |
| Headlands Technologies LLC | 0 | 3,953 | +3,953 | 0.00 | 0.10 | +0.10 | buy |
| Cavalier Investments, LLC | 0 | 3,641 | +3,641 | 0.00 | 0.24 | +0.24 | buy |
| FIRST TRUST ADVISORS LP | 0 | 2,662 | +2,662 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 2,645 | +2,645 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 46,571 | 48,942 | +2,371 | 0.01 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 6,816 | 8,807 | +1,991 | 0.07 | 0.07 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 1,951 | +1,951 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 1,936 | +1,936 | 0.00 | 0.08 | +0.08 | buy |
| Blueshift Asset Management, LLC | 0 | 1,852 | +1,852 | 0.00 | 0.10 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 1,736 | +1,736 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 2,504 | 4,176 | +1,672 | 0.10 | 0.10 | -0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 1,643 | +1,643 | 0.00 | 0.08 | +0.08 | buy |
| Engineers Gate Manager LP | 0 | 1,501 | +1,501 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 1,394 | +1,394 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 3,298 | 4,598 | +1,300 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 8,375 | 9,648 | +1,273 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 71,185 | 72,395 | +1,210 | 3.10 | 2.30 | -0.79 | buy |
| GROUPAMA ASSET MANAGMENT | 11,874 | 12,837 | +963 | 0.05 | 0.06 | +0.01 | buy |
| Handelsbanken Fonder AB | 31,600 | 32,500 | +900 | 0.04 | 0.03 | -0.01 | buy |
| OSAIC HOLDINGS, INC. | 1,418 | 2,154 | +736 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 661 | +661 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 1,333 | 1,993 | +660 | 0.47 | 0.83 | +0.35 | buy |
| E Fund Management Co., Ltd. | 2,212 | 2,863 | +651 | 0.03 | 0.03 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 44,570 | 45,130 | +560 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 4,610 | 5,118 | +508 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 2,764 | 3,207 | +443 | 0.00 | 0.00 | -0.00 | buy |
| WOLVERINE TRADING, LLC | 4,582 | 4,999 | +417 | 0.02 | 0.03 | +0.01 | buy |
| NEOS Investment Management LLC | 4,598 | 4,978 | +380 | 0.05 | 0.03 | -0.02 | buy |
| AlphaQuest LLC | 213 | 581 | +368 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 352 | +352 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 3,335 | 3,646 | +311 | 0.01 | 0.01 | -0.00 | buy |
| ASSETMARK, INC | 3,639 | 3,942 | +303 | 0.00 | 0.00 | -0.00 | buy |
| Everhart Financial Group, Inc. | 1,403 | 1,653 | +250 | 0.10 | 0.08 | -0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 111,113 | 111,363 | +250 | 0.02 | 0.01 | -0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,454 | 14,667 | +213 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 24,800 | 25,000 | +200 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 3,525 | 3,683 | +158 | 0.01 | 0.00 | -0.00 | buy |
| Kestra Advisory Services, LLC | 2,469 | 2,614 | +145 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 13,430 | 13,572 | +142 | 0.00 | 0.00 | -0.00 | buy |
| BROWN ADVISORY INC | 1,500 | 1,625 | +125 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 2,888 | 2,998 | +110 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,280 | 1,383 | +103 | 0.00 | 0.00 | -0.00 | buy |
| Verity Asset Management, Inc. | 1,365 | 1,466 | +101 | 0.15 | 0.12 | -0.03 | buy |
| Creative Planning | 3,212 | 3,299 | +87 | 0.00 | 0.00 | -0.00 | buy |
| Snowden Capital Advisors LLC | 1,462 | 1,539 | +77 | 0.01 | 0.01 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 143 | 211 | +68 | 0.00 | 0.00 | +0.00 | buy |
| EASTERN BANK | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 621 | 683 | +62 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,719 | 1,777 | +58 | 0.02 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 1,322 | 1,373 | +51 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 27 | 69 | +42 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 2,252 | 2,292 | +40 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 1,117 | 1,155 | +38 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 22,262 | 22,295 | +33 | 0.00 | 0.00 | -0.00 | buy |