| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 1,850,000 | 2,042,000 | +192,000 | 38.31 | 27.55 | -10.76 | buy |
| RTW INVESTMENTS, LP | 1,915,862 | 1,993,687 | +77,825 | 8.31 | 6.12 | -2.19 | buy |
| CIBC Private Wealth Group LLC | 30,051 | 3,100 | +26,951 | 0.02 | 0.00 | 0.00 | sell |
| Rock Springs Capital Management LP | 245,499 | 263,062 | +17,563 | 2.07 | 1.82 | -0.25 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 83,062 | 72,083 | +10,979 | 0.10 | 0.07 | -0.02 | sell |
| Woodline Partners LP | 138,309 | 147,090 | +8,781 | 0.37 | 0.26 | -0.11 | buy |
| Rafferty Asset Management, LLC | 36,418 | 44,624 | +8,206 | 0.04 | 0.03 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 12,708 | 20,842 | +8,134 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,485,751 | 2,478,160 | +7,591 | 0.38 | 0.27 | 0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,954 | 14,024 | +5,070 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 5,682 | 9,762 | +4,080 | 1.70 | 1.78 | +0.09 | buy |
| PROFUND ADVISORS LLC | 6,816 | 8,807 | +1,991 | 0.07 | 0.07 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,504 | 4,176 | +1,672 | 0.10 | 0.10 | -0.00 | buy |
| ProShare Advisors LLC | 3,298 | 4,598 | +1,300 | 0.00 | 0.00 | 0.00 | buy |
| MPM BioImpact LLC | 71,185 | 72,395 | +1,210 | 3.10 | 2.30 | -0.79 | buy |
| Rockefeller Capital Management L.P. | 19,088 | 18,088 | +1,000 | 0.02 | 0.01 | 0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 11,874 | 12,837 | +963 | 0.05 | 0.06 | +0.01 | buy |
| JGP Global Gestao de Recursos Ltda. | 1,333 | 1,993 | +660 | 0.47 | 0.83 | +0.35 | buy |
| E Fund Management Co., Ltd. | 2,212 | 2,863 | +651 | 0.03 | 0.03 | -0.00 | buy |
| NEOS Investment Management LLC | 4,598 | 4,978 | +380 | 0.05 | 0.03 | -0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 111,113 | 111,363 | +250 | 0.02 | 0.01 | -0.01 | buy |
| Everhart Financial Group, Inc. | 1,403 | 1,653 | +250 | 0.10 | 0.08 | -0.02 | buy |
| Verity Asset Management, Inc. | 1,365 | 1,466 | +101 | 0.15 | 0.12 | -0.03 | buy |
| Ameritas Investment Partners, Inc. | 1,719 | 1,777 | +58 | 0.02 | 0.01 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 1,476 | 1,507 | +31 | 0.01 | 0.00 | 0.00 | buy |
| CENTAURUS FINANCIAL, INC. | 583 | 611 | +28 | 0.01 | 0.01 | -0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 13,325 | 13,328 | +3 | 0.16 | 0.10 | -0.06 | buy |
| Simplify Asset Management Inc. | 23,313 | 23,305 | -8 | 0.57 | 0.34 | -0.23 | sell |
| SECTORAL ASSET MANAGEMENT INC | 1,065 | 1,045 | -20 | 0.12 | 0.13 | +0.01 | sell |
| PITCAIRN CO | 1,091 | 1,027 | -64 | 0.02 | 0.01 | -0.01 | sell |
| Dana Investment Advisors, Inc. | 3,713 | 3,584 | -129 | 0.04 | 0.03 | -0.01 | sell |
| J. Safra Sarasin Holding AG | 5,751 | 5,600 | -151 | 0.03 | 0.02 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 38,377 | 38,133 | -244 | 0.13 | 0.10 | -0.04 | sell |
| HighVista Strategies LLC | 2,534 | 2,211 | -323 | 0.26 | 0.16 | -0.10 | sell |
| AMI ASSET MANAGEMENT CORP | 5,485 | 5,013 | -472 | 0.08 | 0.06 | -0.03 | sell |
| Hennion & Walsh Asset Management, Inc. | 20,337 | 18,917 | -1,420 | 0.29 | 0.19 | -0.11 | sell |
| Bayesian Capital Management, LP | 3,409 | 1,502 | -1,907 | 0.11 | 0.04 | -0.07 | sell |
| Knights of Columbus Asset Advisors LLC | 5,246 | 2,579 | -2,667 | 0.10 | 0.04 | -0.06 | sell |
| Fiera Capital Corp | 115,415 | 111,880 | -3,535 | 0.10 | 0.07 | -0.03 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 51,173 | 46,445 | -4,728 | 0.02 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 102,455 | 93,446 | -9,009 | 0.14 | 0.10 | -0.04 | sell |
| Affinity Asset Advisors, LLC | 110,000 | 100,000 | -10,000 | 3.55 | 2.90 | -0.66 | sell |
| Erste Asset Management GmbH | 245,380 | 234,400 | -10,980 | 0.91 | 0.60 | -0.32 | sell |
| Rheos Capital Works Inc. | 110,215 | 99,215 | -11,000 | 1.62 | 1.10 | -0.52 | sell |
| Rhenman & Partners Asset Management AB | 26,500 | 15,300 | -11,200 | 0.71 | 0.26 | -0.45 | sell |
| TD ASSET MANAGEMENT INC | 55,730 | 38,130 | -17,600 | 0.01 | 0.01 | -0.01 | sell |
| Tri Locum Partners LP | 65,352 | 43,287 | -22,065 | 4.63 | 2.20 | -2.43 | sell |
| Polar Capital Holdings Plc | 125,300 | 100,475 | -24,825 | 0.21 | 0.10 | -0.11 | sell |
| ArrowMark Colorado Holdings LLC | 187,393 | 161,952 | -25,441 | 0.63 | 0.44 | -0.19 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 35,112 | 8,955 | -26,157 | 100.00 | 13.70 | -86.30 | sell |
| Avoro Capital Advisors LLC | 2,055,555 | 2,029,000 | -26,555 | 7.67 | 6.28 | -1.39 | sell |
| Artisan Partners Limited Partnership | 345,085 | 306,846 | -38,239 | 0.14 | 0.10 | -0.05 | sell |
| AlpInvest Partners B.V. | 84,595 | 42,297 | -42,298 | 8.50 | 5.31 | -3.19 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 75,759 | 21,687 | -54,072 | 1.11 | 0.24 | -0.87 | sell |
| EMERALD ADVISERS, LLC | 96,764 | 27,265 | -69,499 | 1.14 | 0.22 | -0.91 | sell |
| ARMISTICE CAPITAL, LLC | 150,000 | 49,915 | -100,085 | 0.53 | 0.17 | -0.36 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 858,765 | 733,697 | -125,068 | 0.03 | 0.02 | -0.01 | sell |