| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 1,976,018 | 2,141,701 | +165,683 | 5.80 | 7.10 | +1.30 | buy |
| RTW INVESTMENTS, LP | 1,993,687 | 1,993,687 | 0 | 8.59 | 11.27 | +2.67 | hold |
| PAULSON & CO. INC. | 2,089,523 | 1,907,523 | -182,000 | 31.44 | 29.46 | -1.98 | sell |
| JANUS HENDERSON GROUP PLC | 2,191,753 | 1,842,690 | -349,063 | 0.33 | 0.39 | +0.06 | sell |
| Avoro Capital Advisors LLC | 1,875,000 | 1,833,000 | -42,000 | 9.94 | 10.88 | +0.94 | sell |
| VANGUARD GROUP INC | 1,877,281 | 1,812,054 | -65,227 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 1,438,724 | 1,559,712 | +120,988 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 690,715 | 658,097 | -32,618 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 414,392 | 446,233 | +31,841 | 0.01 | 0.01 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 350,289 | 411,802 | +61,513 | 0.28 | 0.49 | +0.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,379 | 404,455 | +397,076 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 445,339 | 401,136 | -44,203 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 189,840 | 386,100 | +196,260 | 0.01 | 0.03 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 508,464 | 352,520 | -155,944 | 0.02 | 0.02 | -0.00 | sell |
| Invesco Ltd. | 200,356 | 299,565 | +99,209 | 0.01 | 0.02 | +0.01 | buy |
| Polar Capital Holdings Plc | 225,410 | 265,154 | +39,744 | 0.36 | 0.59 | +0.23 | buy |
| MORGAN STANLEY | 247,962 | 249,647 | +1,685 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 277,221 | 244,292 | -32,929 | 0.01 | 0.01 | +0.00 | sell |
| Hood River Capital Management LLC | 244,738 | 242,808 | -1,930 | 1.03 | 1.31 | +0.28 | sell |
| UBS Group AG | 505,714 | 217,343 | -288,371 | 0.03 | 0.02 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 153,085 | 213,652 | +60,567 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 201,571 | 206,254 | +4,683 | 0.09 | 0.14 | +0.05 | buy |
| Erste Asset Management GmbH | 201,100 | 201,100 | 0 | 0.51 | 0.86 | +0.35 | hold |
| Pictet Asset Management Holding SA | 208,266 | 191,796 | -16,470 | 0.06 | 0.08 | +0.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 167,784 | 165,615 | -2,169 | 0.03 | 0.04 | +0.01 | sell |
| NORTHERN TRUST CORP | 142,868 | 159,988 | +17,120 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 140,296 | 137,746 | -2,550 | 2.65 | 3.69 | +1.05 | sell |
| Fiera Capital Corp | 130,622 | 127,800 | -2,822 | 0.13 | 0.19 | +0.06 | sell |
| ArrowMark Colorado Holdings LLC | 144,808 | 123,259 | -21,549 | 0.79 | 1.05 | +0.26 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,836 | 120,682 | +109,846 | 0.00 | 0.07 | +0.07 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 0 | 120,000 | +120,000 | 0.00 | 0.25 | +0.25 | buy |
| ARMISTICE CAPITAL, LLC | 124,000 | 119,982 | -4,018 | 1.42 | 1.73 | +0.30 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 115,974 | +115,974 | 0.00 | 0.38 | +0.38 | buy |
| Affinity Asset Advisors, LLC | 80,000 | 115,000 | +35,000 | 3.58 | 4.91 | +1.33 | buy |
| Redwood Wealth Management Group, LLC | 110,153 | 106,751 | -3,402 | 1.33 | 1.28 | -0.05 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 100,322 | 104,818 | +4,496 | 0.05 | 0.07 | +0.02 | buy |
| Woodline Partners LP | 159,623 | 103,847 | -55,776 | 0.26 | 0.22 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 84,217 | 102,143 | +17,926 | 0.08 | 0.14 | +0.06 | buy |
| MPM BioImpact LLC | 100,415 | 100,415 | 0 | 5.27 | 7.54 | +2.27 | hold |
| Bank of New York Mellon Corp | 88,943 | 97,779 | +8,836 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 111,981 | 96,182 | -15,799 | 0.03 | 0.04 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 95,734 | +95,734 | 0.00 | 0.05 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 376,163 | 88,500 | -287,663 | 0.19 | 0.06 | -0.13 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 100,095 | 85,773 | -14,322 | 0.11 | 0.12 | +0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 34,500 | 82,401 | +47,901 | 0.02 | 0.08 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 60,715 | 75,570 | +14,855 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 75,000 | 75,000 | 0 | 1.35 | 1.65 | +0.31 | hold |
| Nuveen, LLC | 41,533 | 73,715 | +32,182 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 69,037 | 70,757 | +1,720 | 0.02 | 0.03 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 54,933 | 70,584 | +15,651 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 61,062 | 69,273 | +8,211 | 0.02 | 0.04 | +0.02 | buy |
| Soleus Capital Management, L.P. | 8,000 | 68,336 | +60,336 | 0.17 | 1.68 | +1.51 | buy |
| Tri Locum Partners LP | 97,765 | 67,706 | -30,059 | 8.98 | 7.14 | -1.84 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 51,090 | 59,437 | +8,347 | 0.02 | 0.03 | +0.01 | buy |
| Iron Triangle Partners LP | 0 | 58,378 | +58,378 | 0.00 | 3.81 | +3.81 | buy |
| Ensign Peak Advisors, Inc | 48,399 | 53,267 | +4,868 | 0.03 | 0.04 | +0.02 | buy |
| EULAV Asset Management | 31,000 | 51,000 | +20,000 | 0.22 | 0.54 | +0.32 | buy |
| EMERALD ADVISERS, LLC | 53,108 | 50,737 | -2,371 | 0.59 | 0.75 | +0.16 | sell |
| Mirae Asset Global Investments Co., Ltd. | 70,559 | 50,578 | -19,981 | 0.07 | 0.07 | -0.00 | sell |
| Candriam S.C.A. | 49,965 | 49,965 | 0 | 0.09 | 0.12 | +0.03 | hold |
| BARCLAYS PLC | 62,674 | 49,912 | -12,762 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 207,339 | 48,372 | -158,967 | 0.05 | 0.02 | -0.04 | sell |
| JPMORGAN CHASE & CO | 55,854 | 47,824 | -8,030 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 34,015 | 44,885 | +10,870 | 0.01 | 0.02 | +0.01 | buy |
| Rheos Capital Works Inc. | 43,215 | 43,215 | 0 | 0.75 | 1.11 | +0.36 | hold |
| Point72 Asset Management, L.P. | 110,877 | 41,233 | -69,644 | 0.08 | 0.04 | -0.04 | sell |
| Tao Capital Management LP | 112,785 | 41,000 | -71,785 | 25.03 | 14.22 | -10.80 | sell |
| WELLS FARGO & COMPANY/MN | 36,669 | 37,818 | +1,149 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 24,115 | 37,342 | +13,227 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,250 | 35,695 | +14,445 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 36,920 | 35,091 | -1,829 | 0.68 | 0.83 | +0.15 | sell |
| Ally Bridge Group (NY) LLC | 0 | 32,662 | +32,662 | 0.00 | 12.54 | +12.54 | buy |
| GILDER GAGNON HOWE & CO LLC | 31,553 | 30,848 | -705 | 0.10 | 0.14 | +0.04 | sell |
| Squarepoint Ops LLC | 4,382 | 29,936 | +25,554 | 0.00 | 0.03 | +0.03 | buy |
| STEADFAST CAPITAL MANAGEMENT LP | 0 | 29,800 | +29,800 | 0.00 | 0.25 | +0.25 | buy |
| Swiss National Bank | 27,400 | 27,900 | +500 | 0.00 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 0 | 27,785 | +27,785 | 0.00 | 0.05 | +0.05 | buy |
| GROUPAMA ASSET MANAGMENT | 40,891 | 27,444 | -13,447 | 0.20 | 0.18 | -0.02 | sell |
| RHUMBLINE ADVISERS | 26,363 | 27,263 | +900 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 27,583 | 24,097 | -3,486 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 39,809 | 23,476 | -16,333 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 14,121 | 22,538 | +8,417 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 22,490 | +22,490 | 0.00 | 0.14 | +0.14 | buy |
| Legal & General Group Plc | 23,109 | 21,671 | -1,438 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 1,367 | 21,328 | +19,961 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 0 | 20,956 | +20,956 | 0.00 | 0.15 | +0.15 | buy |
| ROYAL BANK OF CANADA | 9,603 | 20,173 | +10,570 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 17,542 | 19,115 | +1,573 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 24,533 | 18,715 | -5,818 | 0.02 | 0.03 | +0.00 | sell |
| Neuberger Berman Group LLC | 0 | 18,531 | +18,531 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 17,948 | 18,451 | +503 | 0.01 | 0.02 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 3,978 | 18,363 | +14,385 | 0.01 | 0.03 | +0.03 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 18,291 | +18,291 | 0.00 | 0.02 | +0.02 | buy |
| Rhenman & Partners Asset Management AB | 0 | 18,250 | +18,250 | 0.00 | 0.93 | +0.93 | buy |
| Cubist Systematic Strategies, LLC | 0 | 17,889 | +17,889 | 0.00 | 0.12 | +0.12 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,416 | 17,327 | -6,089 | 0.01 | 0.01 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 33,207 | 16,612 | -16,595 | 0.01 | 0.01 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 3,131 | 15,288 | +12,157 | 0.00 | 0.01 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 0 | 15,000 | +15,000 | 0.00 | 3.60 | +3.60 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,502 | 14,566 | +64 | 0.00 | 0.00 | +0.00 | buy |