| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 500,000 | 1,105,741 | +605,741 | 6.53 | 23.09 | +16.56 | buy |
| RTW INVESTMENTS, LP | 309,485 | 815,191 | +505,706 | 0.95 | 2.95 | +1.99 | buy |
| BAKER BROS. ADVISORS LP | 1,545,113 | 1,969,798 | +424,685 | 1.30 | 5.19 | +3.89 | buy |
| Avoro Capital Advisors LLC | 1,555,000 | 1,888,888 | +333,888 | 3.54 | 6.04 | +2.49 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 324,619 | +324,619 | 0.00 | 7.20 | +7.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 170,373 | 388,729 | +218,356 | 0.00 | 0.01 | +0.01 | buy |
| AlpInvest Partners B.V. | 0 | 211,488 | +211,488 | 0.00 | 11.18 | +11.18 | buy |
| FMR LLC | 440,380 | 625,165 | +184,785 | 0.01 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 75,688 | 191,931 | +116,243 | 0.44 | 1.40 | +0.96 | buy |
| JANE STREET GROUP, LLC | 103,386 | 216,818 | +113,432 | 0.02 | 0.06 | +0.04 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 82,287 | +82,287 | 0.00 | 1.03 | +1.03 | buy |
| Erste Asset Management GmbH | 250,400 | 325,000 | +74,600 | 0.63 | 1.10 | +0.47 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 69,406 | +69,406 | 0.00 | 0.86 | +0.86 | buy |
| Pictet Asset Management Holding SA | 111,425 | 171,165 | +59,740 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 642,266 | 700,739 | +58,473 | 0.01 | 0.01 | +0.00 | buy |
| Tao Capital Management LP | 77,657 | 130,529 | +52,872 | 8.78 | 27.63 | +18.85 | buy |
| LMR Partners LLP | 0 | 51,885 | +51,885 | 0.00 | 0.30 | +0.30 | buy |
| EMERALD ADVISERS, LLC | 878 | 47,722 | +46,844 | 0.01 | 0.47 | +0.47 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 296,438 | 336,255 | +39,817 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,113 | 59,785 | +39,672 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 39,280 | +39,280 | 0.00 | 0.48 | +0.48 | buy |
| University of Wisconsin Foundation | 40,133 | 73,487 | +33,354 | 6.72 | 28.29 | +21.58 | buy |
| UBS Group AG | 56,185 | 88,377 | +32,192 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 124,637 | 151,151 | +26,514 | 0.61 | 0.78 | +0.17 | buy |
| Rhenman & Partners Asset Management AB | 0 | 22,500 | +22,500 | 0.00 | 0.52 | +0.52 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 21,174 | +21,174 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,119 | 62,773 | +18,654 | 0.01 | 0.02 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 18,300 | +18,300 | 0.00 | 0.01 | +0.01 | buy |
| Artisan Partners Limited Partnership | 280,090 | 296,480 | +16,390 | 0.07 | 0.11 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 0 | 15,540 | +15,540 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 43,871 | 59,397 | +15,526 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 85,000 | 100,000 | +15,000 | 4.06 | 4.61 | +0.56 | buy |
| Rockefeller Capital Management L.P. | 18,114 | 33,040 | +14,926 | 0.01 | 0.03 | +0.02 | buy |
| EULAV Asset Management | 0 | 13,000 | +13,000 | 0.00 | 0.09 | +0.09 | buy |
| AMERICAN CENTURY COMPANIES INC | 63,609 | 75,873 | +12,264 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 26,410 | 38,354 | +11,944 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 123,649 | 134,706 | +11,057 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 109,501 | 120,212 | +10,711 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 51,047 | 61,412 | +10,365 | 0.02 | 0.03 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 5,914 | 15,622 | +9,708 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 76,412 | 85,103 | +8,691 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 7,763 | +7,763 | 0.00 | 0.00 | +0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 7,718 | 15,147 | +7,429 | 0.08 | 0.22 | +0.14 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,621 | 22,769 | +6,148 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 109,505 | 114,904 | +5,399 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 5,227 | +5,227 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 4,773 | +4,773 | 0.00 | 0.06 | +0.06 | buy |
| ROYAL BANK OF CANADA | 2,222 | 6,715 | +4,493 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 4,309 | 8,695 | +4,386 | 0.06 | 0.13 | +0.07 | buy |
| Virtu Financial LLC | 0 | 4,063 | +4,063 | 0.00 | 0.07 | +0.07 | buy |
| HRT FINANCIAL LP | 0 | 3,716 | +3,716 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 0 | 3,572 | +3,572 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 58,786 | 62,178 | +3,392 | 0.00 | 0.00 | +0.00 | buy |
| Capital Impact Advisors, LLC | 2,139 | 4,992 | +2,853 | 0.52 | 1.52 | +1.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,156 | 13,003 | +2,847 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 14,243 | 16,949 | +2,706 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 51,686 | 54,107 | +2,421 | 0.04 | 0.06 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 2,350 | +2,350 | 0.00 | 0.04 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 2,293 | +2,293 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,860 | 16,079 | +2,219 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 2,200 | +2,200 | 0.00 | 0.14 | +0.14 | buy |
| Headlands Technologies LLC | 0 | 2,045 | +2,045 | 0.00 | 0.14 | +0.14 | buy |
| NEOS Investment Management LLC | 0 | 1,892 | +1,892 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 468 | 2,292 | +1,824 | 0.02 | 0.10 | +0.08 | buy |
| Rock Springs Capital Management LP | 196,369 | 198,169 | +1,800 | 0.77 | 1.13 | +0.36 | buy |
| L1 Capital Pty Ltd | 48,469 | 50,230 | +1,761 | 0.60 | 1.09 | +0.49 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,594 | 18,347 | +1,753 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 1,722 | +1,722 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 7,105 | 8,662 | +1,557 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 1,551 | +1,551 | 0.00 | 0.03 | +0.03 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 1,474 | +1,474 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,573,338 | 1,574,742 | +1,404 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 19,223 | 20,624 | +1,401 | 0.00 | 0.01 | +0.00 | buy |
| FIL Ltd | 0 | 1,391 | +1,391 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 1,305 | +1,305 | 0.00 | 0.18 | +0.18 | buy |
| Mariner, LLC | 0 | 1,262 | +1,262 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,247 | +1,247 | 0.00 | 0.01 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 0 | 1,182 | +1,182 | 0.00 | 0.17 | +0.17 | buy |
| Everhart Financial Group, Inc. | 0 | 1,143 | +1,143 | 0.00 | 0.09 | +0.09 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 1,120 | +1,120 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 1,027 | +1,027 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 1,000 | +1,000 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 0 | 992 | +992 | 0.00 | 0.05 | +0.05 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 2,019 | 3,000 | +981 | 0.03 | 0.06 | +0.03 | buy |
| New Harbor Financial Group, LLC | 0 | 911 | +911 | 0.00 | 0.09 | +0.09 | buy |
| HighTower Advisors, LLC | 0 | 903 | +903 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 891 | +891 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 10,088 | 10,918 | +830 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 2,977 | 3,711 | +734 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 4,233 | 4,941 | +708 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 5,983 | 6,644 | +661 | 0.02 | 0.03 | +0.01 | buy |
| MetLife Investment Management, LLC | 7,177 | 7,758 | +581 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 6,796 | 7,354 | +558 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 2,800 | 3,300 | +500 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 1,421 | 1,920 | +499 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 4,217 | 4,503 | +286 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 3,137 | 3,421 | +284 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,060 | 2,312 | +252 | 0.01 | 0.01 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 2,178 | 2,405 | +227 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,901 | 12,095 | +194 | 0.00 | 0.00 | +0.00 | buy |