| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PAULSON & CO. INC. | 500,000 | 1,105,741 | +605,741 | 6.53 | 23.09 | +16.56 | buy |
| RTW INVESTMENTS, LP | 309,485 | 815,191 | +505,706 | 0.95 | 2.95 | +1.99 | buy |
| BAKER BROS. ADVISORS LP | 1,545,113 | 1,969,798 | +424,685 | 1.30 | 5.19 | +3.89 | buy |
| Avoro Capital Advisors LLC | 1,555,000 | 1,888,888 | +333,888 | 3.54 | 6.04 | +2.49 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 170,373 | 388,729 | +218,356 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,042,661 | 2,902,050 | +140,611 | 0.29 | 0.40 | 0.00 | sell |
| Erste Asset Management GmbH | 250,400 | 325,000 | +74,600 | 0.63 | 1.10 | +0.47 | buy |
| Tao Capital Management LP | 77,657 | 130,529 | +52,872 | 8.78 | 27.63 | +18.85 | buy |
| EMERALD ADVISERS, LLC | 878 | 47,722 | +46,844 | 0.01 | 0.47 | +0.47 | buy |
| University of Wisconsin Foundation | 40,133 | 73,487 | +33,354 | 6.72 | 28.29 | +21.58 | buy |
| PERCEPTIVE ADVISORS LLC | 124,637 | 151,151 | +26,514 | 0.61 | 0.78 | +0.17 | buy |
| Artisan Partners Limited Partnership | 280,090 | 296,480 | +16,390 | 0.07 | 0.11 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 85,000 | 100,000 | +15,000 | 4.06 | 4.61 | +0.56 | buy |
| Rockefeller Capital Management L.P. | 18,114 | 33,040 | +14,926 | 0.01 | 0.03 | 0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 7,718 | 15,147 | +7,429 | 0.08 | 0.22 | +0.14 | buy |
| Knights of Columbus Asset Advisors LLC | 4,309 | 8,695 | +4,386 | 0.06 | 0.13 | +0.07 | buy |
| Capital Impact Advisors, LLC | 2,139 | 4,992 | +2,853 | 0.52 | 1.52 | +1.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 51,686 | 54,107 | +2,421 | 0.04 | 0.06 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 468 | 2,292 | +1,824 | 0.02 | 0.10 | +0.08 | buy |
| Rock Springs Capital Management LP | 196,369 | 198,169 | +1,800 | 0.77 | 1.13 | +0.36 | buy |
| L1 Capital Pty Ltd | 48,469 | 50,230 | +1,761 | 0.60 | 1.09 | +0.49 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 2,019 | 3,000 | +981 | 0.03 | 0.06 | +0.03 | buy |
| ProShare Advisors LLC | 2,977 | 3,711 | +734 | 0.00 | 0.00 | 0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 5,983 | 6,644 | +661 | 0.02 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 7,723 | 7,160 | +563 | 0.06 | 0.07 | 0.00 | sell |
| Dana Investment Advisors, Inc. | 3,047 | 3,171 | +124 | 0.02 | 0.04 | +0.01 | buy |
| MPM BioImpact LLC | 40,859 | 40,910 | +51 | 1.59 | 2.21 | +0.62 | buy |
| NATIXIS | 902 | 857 | +45 | 0.00 | 0.00 | 0.00 | sell |
| LIBERTY ONE INVESTMENT MANAGEMENT, LLC | 518 | 552 | +34 | 0.01 | 0.02 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 388 | 397 | +9 | 0.03 | 0.06 | +0.02 | buy |
| Verity Asset Management, Inc. | 2,687 | 2,689 | +2 | 0.29 | 0.40 | +0.11 | buy |
| E Fund Management Co., Ltd. | 2,327 | 2,306 | -21 | 0.03 | 0.03 | +0.01 | sell |
| Knott David M Jr | 15,000 | 14,800 | -200 | 0.84 | 1.31 | +0.47 | sell |
| FIRST NATIONAL TRUST CO | 4,869 | 4,414 | -455 | 0.03 | 0.04 | +0.01 | sell |
| Edgestream Partners, L.P. | 1,567 | 987 | -580 | 0.02 | 0.02 | -0.00 | sell |
| HighVista Strategies LLC | 3,045 | 1,431 | -1,614 | 0.21 | 0.12 | -0.09 | sell |
| FRED ALGER MANAGEMENT, LLC | 19,864 | 18,097 | -1,767 | 0.02 | 0.02 | +0.01 | sell |
| Candriam S.C.A. | 29,000 | 27,000 | -2,000 | 0.03 | 0.04 | +0.01 | sell |
| Rafferty Asset Management, LLC | 45,323 | 43,099 | -2,224 | 0.04 | 0.04 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 13,579 | 9,223 | -4,356 | 0.38 | 0.38 | +0.01 | sell |
| MBB PUBLIC MARKETS I LLC | 5,990 | 1,400 | -4,590 | 0.06 | 0.02 | -0.04 | sell |
| Tri Locum Partners LP | 33,761 | 25,524 | -8,237 | 1.58 | 2.90 | +1.32 | sell |
| Hennion & Walsh Asset Management, Inc. | 35,972 | 26,926 | -9,046 | 0.33 | 0.36 | +0.02 | sell |
| CenterBook Partners LP | 18,027 | 953 | -17,074 | 0.33 | 0.03 | -0.30 | sell |
| SECTORAL ASSET MANAGEMENT INC | 20,901 | 1,201 | -19,700 | 0.59 | 0.12 | -0.47 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 50,867 | 27,767 | -23,100 | 1.35 | 1.03 | -0.32 | sell |
| ARMISTICE CAPITAL, LLC | 108,000 | 50,000 | -58,000 | 0.24 | 0.16 | -0.08 | sell |