| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 2,478,160 | 2,208,394 | -269,766 | 0.27 | 0.35 | +0.08 | sell |
| PAULSON & CO. INC. | 2,042,000 | 2,042,000 | 0 | 27.55 | 38.14 | +10.59 | hold |
| Avoro Capital Advisors LLC | 2,029,000 | 2,029,000 | 0 | 6.28 | 8.86 | +2.58 | hold |
| RTW INVESTMENTS, LP | 1,993,687 | 1,993,687 | 0 | 6.12 | 9.30 | +3.18 | hold |
| BAKER BROS. ADVISORS LP | 1,974,590 | 1,974,590 | 0 | 4.34 | 6.51 | +2.17 | hold |
| VANGUARD GROUP INC | 1,833,768 | 1,706,135 | -127,633 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 1,461,386 | 1,494,167 | +32,781 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 783,545 | 867,850 | +84,305 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 887,752 | 781,288 | -106,464 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 733,697 | 588,764 | -144,933 | 0.02 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 405,655 | 410,578 | +4,923 | 0.01 | 0.01 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 0 | 371,771 | +371,771 | 0.00 | 0.28 | +0.28 | buy |
| UBS Group AG | 180,630 | 325,274 | +144,644 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 147,090 | 309,117 | +162,027 | 0.26 | 0.65 | +0.38 | buy |
| Rock Springs Capital Management LP | 263,062 | 265,212 | +2,150 | 1.82 | 3.12 | +1.30 | buy |
| GOLDMAN SACHS GROUP INC | 239,780 | 231,450 | -8,330 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 269,394 | 218,481 | -50,913 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 214,888 | 217,828 | +2,940 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 150,598 | 208,484 | +57,886 | 0.04 | 0.07 | +0.03 | buy |
| Artisan Partners Limited Partnership | 306,846 | 207,469 | -99,377 | 0.10 | 0.10 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 161,952 | 199,667 | +37,715 | 0.44 | 0.83 | +0.39 | buy |
| Erste Asset Management GmbH | 234,400 | 164,400 | -70,000 | 0.60 | 0.63 | +0.03 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 44,497 | 160,782 | +116,285 | 0.01 | 0.07 | +0.06 | buy |
| NORTHERN TRUST CORP | 147,772 | 155,883 | +8,111 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 147,970 | 150,746 | +2,776 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 100,475 | 137,720 | +37,245 | 0.10 | 0.24 | +0.14 | buy |
| AMERICAN CENTURY COMPANIES INC | 111,363 | 136,849 | +25,486 | 0.01 | 0.02 | +0.01 | buy |
| Tao Capital Management LP | 130,529 | 130,529 | 0 | 25.09 | 28.11 | +3.02 | hold |
| Invesco Ltd. | 120,246 | 129,074 | +8,828 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 0 | 127,839 | +127,839 | 0.00 | 0.58 | +0.58 | buy |
| Siren, L.L.C. | 0 | 125,942 | +125,942 | 0.00 | 1.72 | +1.72 | buy |
| NORGES BANK | 69,974 | 115,092 | +45,118 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 111,144 | 112,325 | +1,181 | 1.41 | 1.25 | -0.16 | buy |
| Fiera Capital Corp | 111,880 | 107,422 | -4,458 | 0.07 | 0.10 | +0.03 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 72,083 | 103,288 | +31,205 | 0.07 | 0.14 | +0.07 | buy |
| GROUP ONE TRADING LLC | 123,425 | 100,146 | -23,279 | 1.04 | 1.05 | +0.01 | sell |
| ARMISTICE CAPITAL, LLC | 49,915 | 100,000 | +50,085 | 0.28 | 0.72 | +0.44 | buy |
| CITIGROUP INC | 28,621 | 98,238 | +69,617 | 0.01 | 0.03 | +0.02 | buy |
| Vestal Point Capital, LP | 30,000 | 95,000 | +65,000 | 0.50 | 1.74 | +1.24 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 82,500 | -17,500 | 3.29 | 3.98 | +0.68 | sell |
| EcoR1 Capital, LLC | 75,000 | 75,000 | 0 | 0.55 | 0.92 | +0.38 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 2,292 | 70,635 | +68,343 | 0.00 | 0.02 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 76,822 | 70,179 | -6,643 | 0.07 | 0.09 | +0.02 | sell |
| JPMORGAN CHASE & CO | 70,778 | 64,235 | -6,543 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 60,361 | 60,210 | -151 | 0.00 | 0.00 | +0.00 | sell |
| Rheos Capital Works Inc. | 99,215 | 56,215 | -43,000 | 1.10 | 0.96 | -0.14 | sell |
| BARCLAYS PLC | 40,279 | 53,253 | +12,974 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 48,917 | +48,917 | 0.00 | 0.05 | +0.05 | buy |
| Tri Locum Partners LP | 43,287 | 47,472 | +4,185 | 2.20 | 3.03 | +0.83 | buy |
| DEUTSCHE BANK AG\ | 48,942 | 43,658 | -5,284 | 0.00 | 0.01 | +0.00 | sell |
| Propel Bio Management, LLC | 43,032 | 43,032 | 0 | 5.30 | 13.19 | +7.89 | hold |
| University of Wisconsin Foundation | 45,730 | 41,541 | -4,189 | 6.33 | 9.32 | +2.99 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 46,445 | 40,815 | -5,630 | 0.01 | 0.02 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 45,130 | 37,772 | -7,358 | 0.00 | 0.00 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 38,133 | 36,168 | -1,965 | 0.10 | 0.12 | +0.02 | sell |
| Ensign Peak Advisors, Inc | 15,734 | 35,361 | +19,627 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 29,319 | 34,923 | +5,604 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 44,624 | 33,123 | -11,501 | 0.03 | 0.04 | +0.00 | sell |
| Handelsbanken Fonder AB | 32,500 | 32,800 | +300 | 0.03 | 0.04 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 22,356 | 27,538 | +5,182 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 27,265 | 27,266 | +1 | 0.22 | 0.33 | +0.10 | buy |
| TD ASSET MANAGEMENT INC | 38,130 | 26,330 | -11,800 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 25,000 | 25,600 | +600 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 24,197 | 24,440 | +243 | 0.00 | 0.01 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 12,837 | 24,324 | +11,487 | 0.06 | 0.15 | +0.10 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,957 | 24,080 | -5,877 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 23,844 | +23,844 | 0.00 | 0.01 | +0.01 | buy |
| Simplify Asset Management Inc. | 23,305 | 23,302 | -3 | 0.34 | 0.50 | +0.16 | sell |
| Neuberger Berman Group LLC | 0 | 22,128 | +22,128 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 22,295 | 21,310 | -985 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 19,960 | +19,960 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 21,687 | 18,656 | -3,031 | 0.24 | 0.35 | +0.11 | sell |
| Rockefeller Capital Management L.P. | 18,088 | 18,210 | +122 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 80,401 | 17,494 | -62,907 | 0.02 | 0.01 | -0.02 | sell |
| Proficio Capital Partners LLC | 0 | 17,280 | +17,280 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,207 | 16,323 | -1,884 | 0.01 | 0.01 | +0.00 | sell |
| Aquatic Capital Management LLC | 0 | 15,032 | +15,032 | 0.00 | 0.13 | +0.13 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,667 | 15,001 | +334 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 15,000 | 15,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CITADEL ADVISORS LLC | 54,649 | 14,872 | -39,777 | 0.01 | 0.00 | -0.01 | sell |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 14,760 | +14,760 | 0.00 | 0.09 | +0.09 | buy |
| Legal & General Group Plc | 13,572 | 14,463 | +891 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 14,228 | +14,228 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,024 | 14,162 | +138 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 13,400 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 13,328 | 13,078 | -250 | 0.10 | 0.15 | +0.05 | sell |
| HRT FINANCIAL LP | 10,088 | 12,588 | +2,500 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,441 | 12,546 | +105 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 9,648 | 11,390 | +1,742 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 11,242 | 11,232 | -10 | 0.03 | 0.04 | +0.01 | sell |
| Nan Fung Group Holdings Ltd | 9,762 | 11,122 | +1,360 | 1.78 | 2.94 | +1.15 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 20,842 | 11,047 | -9,795 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 10,900 | +10,900 | 0.00 | 0.25 | +0.25 | buy |
| MetLife Investment Management, LLC | 10,123 | 10,818 | +695 | 0.01 | 0.02 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 10,327 | +10,327 | 0.00 | 0.03 | +0.03 | buy |
| EULAV Asset Management | 10,000 | 10,000 | 0 | 0.05 | 0.07 | +0.02 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 43,614 | 9,942 | -33,672 | 0.01 | 0.00 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 18,917 | 9,904 | -9,013 | 0.19 | 0.14 | -0.05 | sell |
| ALGERT GLOBAL LLC | 0 | 9,770 | +9,770 | 0.00 | 0.07 | +0.07 | buy |
| Twin Tree Management, LP | 0 | 9,738 | +9,738 | 0.00 | 0.07 | +0.07 | buy |