| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 2,141,701 | 2,141,701 | 0 | 7.10 | 7.30 | +0.20 | hold |
| RTW INVESTMENTS, LP | 1,993,687 | 1,993,687 | 0 | 11.27 | 11.63 | +0.36 | hold |
| VANGUARD GROUP INC | 1,812,054 | 1,808,894 | -3,160 | 0.01 | 0.02 | +0.00 | sell |
| Avoro Capital Advisors LLC | 1,833,000 | 1,807,500 | -25,500 | 10.88 | 10.35 | -0.53 | sell |
| PAULSON & CO. INC. | 1,907,523 | 1,707,522 | -200,001 | 29.46 | 30.48 | +1.02 | sell |
| BlackRock, Inc. | 1,559,712 | 1,644,750 | +85,038 | 0.01 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,842,690 | 1,584,843 | -257,847 | 0.39 | 0.41 | +0.03 | sell |
| STATE STREET CORP | 658,097 | 583,003 | -75,094 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 404,455 | 461,402 | +56,947 | 0.03 | 0.05 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 446,233 | 451,743 | +5,510 | 0.01 | 0.02 | +0.00 | buy |
| FMR LLC | 401,136 | 439,398 | +38,262 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 244,292 | 416,025 | +171,733 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 299,565 | 365,314 | +65,749 | 0.02 | 0.03 | +0.00 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 411,802 | 354,220 | -57,582 | 0.49 | 0.58 | +0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 352,520 | 313,659 | -38,861 | 0.02 | 0.02 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 386,100 | 305,847 | -80,253 | 0.03 | 0.03 | -0.00 | sell |
| Polar Capital Holdings Plc | 265,154 | 270,151 | +4,997 | 0.59 | 0.72 | +0.13 | buy |
| ARMISTICE CAPITAL, LLC | 119,982 | 265,705 | +145,723 | 1.73 | 3.79 | +2.06 | buy |
| Hood River Capital Management LLC | 242,808 | 247,560 | +4,752 | 1.31 | 1.58 | +0.27 | buy |
| LORD, ABBETT & CO. LLC | 102,143 | 244,796 | +142,653 | 0.14 | 0.44 | +0.30 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 120,000 | 240,000 | +120,000 | 0.25 | 0.61 | +0.36 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,652 | 219,099 | +5,447 | 0.02 | 0.02 | +0.00 | buy |
| Artisan Partners Limited Partnership | 206,254 | 198,693 | -7,561 | 0.14 | 0.18 | +0.04 | sell |
| NORGES BANK | 0 | 196,393 | +196,393 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 37,342 | 192,109 | +154,767 | 0.01 | 0.04 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 165,615 | 185,116 | +19,501 | 0.04 | 0.05 | +0.02 | buy |
| Pictet Asset Management Holding SA | 191,796 | 181,949 | -9,847 | 0.08 | 0.10 | +0.02 | sell |
| Fiera Capital Corp | 127,800 | 169,456 | +41,656 | 0.19 | 0.31 | +0.12 | buy |
| NORTHERN TRUST CORP | 159,988 | 151,802 | -8,186 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 249,647 | 150,462 | -99,185 | 0.01 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 201,100 | 141,100 | -60,000 | 0.86 | 0.69 | -0.17 | sell |
| Rock Springs Capital Management LP | 137,746 | 139,618 | +1,872 | 3.69 | 4.17 | +0.48 | buy |
| Bank of New York Mellon Corp | 97,779 | 136,869 | +39,090 | 0.01 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 41,233 | 126,435 | +85,202 | 0.04 | 0.12 | +0.07 | buy |
| Woodline Partners LP | 103,847 | 125,659 | +21,812 | 0.22 | 0.28 | +0.06 | buy |
| Nuveen, LLC | 73,715 | 118,363 | +44,648 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 115,974 | 111,666 | -4,308 | 0.38 | 0.44 | +0.06 | sell |
| Redwood Wealth Management Group, LLC | 106,751 | 108,164 | +1,413 | 1.28 | 1.26 | -0.02 | buy |
| UBS Group AG | 217,343 | 102,641 | -114,702 | 0.02 | 0.01 | -0.01 | sell |
| MPM BioImpact LLC | 100,415 | 96,780 | -3,635 | 7.54 | 6.45 | -1.09 | sell |
| JANE STREET GROUP, LLC | 95,734 | 93,114 | -2,620 | 0.05 | 0.06 | +0.01 | sell |
| D. E. Shaw & Co., Inc. | 96,182 | 88,554 | -7,628 | 0.04 | 0.04 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 75,570 | 86,076 | +10,506 | 0.01 | 0.01 | +0.00 | buy |
| Tri Locum Partners LP | 67,706 | 86,023 | +18,317 | 7.14 | 6.50 | -0.63 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 120,682 | 83,862 | -36,820 | 0.07 | 0.08 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 123,259 | 82,624 | -40,635 | 1.05 | 1.06 | +0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 69,273 | 75,933 | +6,660 | 0.04 | 0.06 | +0.02 | buy |
| Squarepoint Ops LLC | 29,936 | 74,934 | +44,998 | 0.03 | 0.09 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 70,757 | 73,707 | +2,950 | 0.03 | 0.03 | +0.00 | buy |
| First Light Asset Management, LLC | 11,539 | 66,831 | +55,292 | 0.50 | 2.98 | +2.48 | buy |
| RAYMOND JAMES FINANCIAL INC | 70,584 | 66,724 | -3,860 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 104,818 | 64,466 | -40,352 | 0.07 | 0.05 | -0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 59,437 | 64,254 | +4,817 | 0.03 | 0.04 | +0.01 | buy |
| Candriam S.C.A. | 49,965 | 63,906 | +13,941 | 0.12 | 0.19 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 85,773 | 58,295 | -27,478 | 0.12 | 0.09 | -0.03 | sell |
| Jain Global LLC | 0 | 52,721 | +52,721 | 0.00 | 0.30 | +0.30 | buy |
| Ensign Peak Advisors, Inc | 53,267 | 51,010 | -2,257 | 0.04 | 0.05 | +0.01 | sell |
| Mirae Asset Global Investments Co., Ltd. | 50,578 | 50,631 | +53 | 0.07 | 0.08 | +0.01 | buy |
| EULAV Asset Management | 51,000 | 49,000 | -2,000 | 0.54 | 0.76 | +0.22 | sell |
| Russell Investments Group, Ltd. | 44,885 | 48,159 | +3,274 | 0.02 | 0.03 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 9,000 | 46,120 | +37,120 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 37,818 | 43,457 | +5,639 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 47,824 | 40,079 | -7,745 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 700 | 39,578 | +38,878 | 0.00 | 0.02 | +0.02 | buy |
| EMERALD ADVISERS, LLC | 50,737 | 38,913 | -11,824 | 0.75 | 0.70 | -0.05 | sell |
| BARCLAYS PLC | 49,912 | 38,720 | -11,192 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 48,372 | 36,134 | -12,238 | 0.02 | 0.01 | -0.00 | sell |
| Atika Capital Management LLC | 0 | 34,000 | +34,000 | 0.00 | 2.76 | +2.76 | buy |
| SEGALL BRYANT & HAMILL, LLC | 22,490 | 33,520 | +11,030 | 0.14 | 0.26 | +0.13 | buy |
| GILDER GAGNON HOWE & CO LLC | 30,848 | 33,468 | +2,620 | 0.14 | 0.21 | +0.06 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 32,871 | +32,871 | 0.00 | 0.06 | +0.06 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 24,097 | 31,286 | +7,189 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 115,000 | 31,131 | -83,869 | 4.91 | 1.30 | -3.60 | sell |
| GROUPAMA ASSET MANAGMENT | 27,444 | 30,620 | +3,176 | 0.18 | 0.26 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 12,997 | 29,287 | +16,290 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 16,612 | 29,051 | +12,439 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 27,900 | 28,580 | +680 | 0.01 | 0.01 | +0.00 | buy |
| STEADFAST CAPITAL MANAGEMENT LP | 29,800 | 26,850 | -2,950 | 0.25 | 0.27 | +0.03 | sell |
| Rheos Capital Works Inc. | 43,215 | 26,215 | -17,000 | 1.11 | 0.98 | -0.13 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 35,091 | 24,996 | -10,095 | 0.83 | 0.71 | -0.12 | sell |
| FIRST TRUST ADVISORS LP | 3,795 | 24,819 | +21,024 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 23,476 | 23,846 | +370 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 27,263 | 23,691 | -3,572 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 9,648 | 23,327 | +13,679 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,500 | 23,226 | -65,274 | 0.06 | 0.02 | -0.04 | sell |
| SEI INVESTMENTS CO | 19,115 | 23,076 | +3,961 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 35,695 | 21,912 | -13,783 | 0.01 | 0.00 | -0.00 | sell |
| Tao Capital Management LP | 41,000 | 21,000 | -20,000 | 14.22 | 10.53 | -3.70 | sell |
| Rockefeller Capital Management L.P. | 18,451 | 19,661 | +1,210 | 0.02 | 0.02 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 18,250 | 19,550 | +1,300 | 0.93 | 1.06 | +0.14 | buy |
| DIMENSIONAL FUND ADVISORS LP | 5,799 | 19,321 | +13,522 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 20,956 | 19,221 | -1,735 | 0.15 | 0.14 | -0.00 | sell |
| Bridgewater Associates, LP | 27,785 | 19,218 | -8,567 | 0.05 | 0.04 | -0.01 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 15,288 | 19,076 | +3,788 | 0.01 | 0.02 | +0.01 | buy |
| Neuberger Berman Group LLC | 18,531 | 18,660 | +129 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 8,207 | 17,736 | +9,529 | 0.76 | 1.77 | +1.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 18,291 | 17,254 | -1,037 | 0.02 | 0.02 | +0.00 | sell |
| LPL Financial LLC | 22,538 | 16,542 | -5,996 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,885 | 16,325 | +12,440 | 0.00 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,327 | 16,052 | -1,275 | 0.01 | 0.01 | +0.00 | sell |