| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.67 | 7.56 | -0.10 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,232,751 | 14,565,457 | +332,706 | 6.41 | 5.83 | -0.58 | buy |
| TCG Crossover Management, LLC | 10,000,000 | 10,000,000 | 0 | 5.21 | 3.94 | -1.28 | hold |
| JENNISON ASSOCIATES LLC | 8,815,358 | 8,841,971 | +26,613 | 0.03 | 0.03 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,637,930 | 8,287,930 | +650,000 | 0.07 | 0.08 | +0.00 | buy |
| VANGUARD GROUP INC | 5,914,947 | 6,063,620 | +148,673 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 4,000,000 | 4,000,000 | 0 | 1.01 | 0.84 | -0.16 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 2,060,173 | 2,779,186 | +719,013 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,817,213 | 2,563,620 | +746,407 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 6,255,406 | 2,394,299 | -3,861,107 | 0.18 | 0.07 | -0.11 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,326,873 | 2,367,805 | +40,932 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 2,382,835 | 2,347,261 | -35,574 | 0.63 | 0.69 | +0.06 | sell |
| Vivo Capital, LLC | 2,088,323 | 2,088,323 | 0 | 0.80 | 0.82 | +0.01 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 814,266 | 2,065,144 | +1,250,878 | 2.73 | 6.80 | +4.07 | buy |
| STATE STREET CORP | 1,768,053 | 1,880,064 | +112,011 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 987,903 | 1,737,410 | +749,507 | 0.46 | 0.85 | +0.38 | buy |
| Altium Capital Management LLC | 1,333,000 | 1,335,000 | +2,000 | 4.32 | 2.97 | -1.35 | buy |
| AXA S.A. | 1,747,673 | 1,330,435 | -417,238 | 0.03 | 0.02 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,150,000 | 1,150,000 | 0 | 1.08 | 0.93 | -0.15 | hold |
| PRUDENTIAL FINANCIAL INC | 972,945 | 1,137,845 | +164,900 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 1,085,666 | +1,085,666 | 0.00 | 0.07 | +0.07 | buy |
| Walleye Capital LLC | 88,926 | 1,025,839 | +936,913 | 0.01 | 0.06 | +0.05 | buy |
| Opaleye Management Inc. | 0 | 855,000 | +855,000 | 0.00 | 0.93 | +0.93 | buy |
| NORTHERN TRUST CORP | 794,909 | 803,159 | +8,250 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 33,165 | 753,885 | +720,720 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 135,842 | 562,186 | +426,344 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 36,215 | 499,115 | +462,900 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 268,447 | 392,723 | +124,276 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 295,701 | 256,183 | -39,518 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 248,562 | 242,575 | -5,987 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 221,510 | 231,564 | +10,054 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 197,430 | +197,430 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 20,600 | 177,100 | +156,500 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 80,201 | 169,225 | +89,024 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 86,343 | 166,992 | +80,649 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 147,000 | +147,000 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 127,200 | 144,880 | +17,680 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 145,275 | 138,211 | -7,064 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 130,064 | 133,929 | +3,865 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 125,749 | 120,941 | -4,808 | 0.00 | 0.00 | -0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 110,669 | +110,669 | 0.00 | 0.31 | +0.31 | buy |
| UBS Group AG | 106,236 | 108,687 | +2,451 | 0.00 | 0.00 | -0.00 | buy |
| AWM Investment Company, Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.07 | +0.07 | buy |
| ALPS ADVISORS INC | 90,919 | 95,462 | +4,543 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 88,548 | +88,548 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 176,886 | 87,437 | -89,449 | 0.03 | 0.01 | -0.01 | sell |
| JANE STREET GROUP, LLC | 60,458 | 85,849 | +25,391 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 37,446 | 85,061 | +47,615 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 79,073 | +79,073 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 123,956 | 78,071 | -45,885 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,869 | 75,986 | +61,117 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 38,225 | 73,494 | +35,269 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 72,624 | +72,624 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 7,509 | 64,014 | +56,505 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 136,700 | 63,876 | -72,824 | 0.02 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 0 | 58,593 | +58,593 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 55,002 | +55,002 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 44,903 | 44,520 | -383 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 102,990 | 43,211 | -59,779 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 48,616 | 39,811 | -8,805 | 0.00 | 0.00 | -0.00 | sell |
| Sivia Capital Partners, LLC | 36,000 | 37,500 | +1,500 | 0.13 | 0.13 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,915 | 35,915 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 22,510 | 34,100 | +11,590 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 49,862 | 33,717 | -16,145 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,067 | 33,692 | +4,625 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 30,098 | 33,665 | +3,567 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,014 | 30,458 | +12,444 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 28,724 | +28,724 | 0.00 | 0.06 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 15,654 | 26,035 | +10,381 | 0.01 | 0.02 | +0.00 | buy |
| Farther Finance Advisors, LLC | 25,782 | 25,782 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ProShare Advisors LLC | 23,601 | 25,715 | +2,114 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 0 | 25,214 | +25,214 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 22,800 | +22,800 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,701 | 21,192 | +5,491 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arizona State Retirement System | 0 | 20,469 | +20,469 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 17,779 | +17,779 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 15,318 | 17,320 | +2,002 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 17,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 17,190 | +17,190 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 16,583 | +16,583 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 12,314 | 16,094 | +3,780 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 45,643 | 15,887 | -29,756 | 0.21 | 0.07 | -0.13 | sell |
| Quarry LP | 4,500 | 15,000 | +10,500 | 0.01 | 0.03 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,803 | +11,803 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 10,910 | +10,910 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,550 | 10,822 | -728 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 10,551 | +10,551 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 2,996 | 10,019 | +7,023 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,054 | 9,054 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 0 | 7,047 | +7,047 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 5,600 | +5,600 | 0.00 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 4,122 | +4,122 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,341 | 3,602 | -1,739 | 0.00 | 0.00 | -0.00 | sell |
| Truvestments Capital LLC | 2,713 | 2,713 | 0 | 0.01 | 0.01 | -0.00 | hold |
| AMALGAMATED BANK | 8,556 | 2,571 | -5,985 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 19,507 | 2,142 | -17,365 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,302 | 2,015 | -287 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 553 | 553 | 0 | 0.00 | 0.00 | -0.00 | hold |