| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 0 | 3,257,639 | +3,257,639 | 0.00 | 0.77 | +0.77 | buy |
| Bain Capital Life Sciences Investors, LLC | 14,565,457 | 17,600,621 | +3,035,164 | 5.26 | 7.21 | +1.95 | buy |
| Frazier Life Sciences Management, L.P. | 8,660,379 | 11,462,301 | +2,801,922 | 1.10 | 1.45 | +0.35 | buy |
| JPMORGAN CHASE & CO | 1,423,139 | 2,183,660 | +760,521 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 2,332,680 | 3,090,213 | +757,533 | 0.28 | 0.39 | +0.11 | buy |
| Sio Capital Management, LLC | 3,747 | 719,654 | +715,907 | 0.00 | 0.60 | +0.60 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,375,888 | 2,014,456 | +638,568 | 0.26 | 0.40 | +0.14 | buy |
| Nantahala Capital Management, LLC | 7,525,259 | 8,075,375 | +550,116 | 1.62 | 1.85 | +0.23 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 508,338 | 966,203 | +457,865 | 1.37 | 3.19 | +1.82 | buy |
| ADAR1 Capital Management, LLC | 988,468 | 1,360,291 | +371,823 | 0.63 | 0.73 | +0.10 | buy |
| BlackRock, Inc. | 9,588,099 | 9,946,311 | +358,212 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 173,396 | 504,011 | +330,615 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 10,775,000 | 11,000,000 | +225,000 | 1.96 | 2.18 | +0.21 | buy |
| Walleye Capital LLC | 0 | 207,299 | +207,299 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 149,629 | +149,629 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 143,661 | 288,674 | +145,013 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 81,343 | 223,016 | +141,673 | 0.01 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 137,694 | +137,694 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 699,698 | 836,397 | +136,699 | 1.62 | 2.08 | +0.46 | buy |
| Point72 Asset Management, L.P. | 700,987 | 797,327 | +96,340 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 87,705 | +87,705 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 103,288 | 181,655 | +78,367 | 0.13 | 0.23 | +0.10 | buy |
| Creative Planning | 15,864 | 93,889 | +78,025 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,211,533 | 1,284,151 | +72,618 | 0.69 | 0.88 | +0.19 | buy |
| UBS Group AG | 134,924 | 184,257 | +49,333 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 49,006 | +49,006 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 20,755 | 65,200 | +44,445 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 214,625 | 256,594 | +41,969 | 0.06 | 0.07 | +0.02 | buy |
| Invesco Ltd. | 48,797 | 89,258 | +40,461 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,784,037 | 2,822,237 | +38,200 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 29,079 | +29,079 | 0.00 | 0.08 | +0.08 | buy |
| Jain Global LLC | 0 | 27,200 | +27,200 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,661 | +26,661 | 0.00 | 0.01 | +0.01 | buy |
| Brooklyn Investment Group | 0 | 23,611 | +23,611 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 22,376 | +22,376 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 10,798 | 26,724 | +15,926 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 51,589 | 67,094 | +15,505 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 141,425 | 153,542 | +12,117 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 12,116 | +12,116 | 0.00 | 0.01 | +0.01 | buy |
| SIH Partners, LLLP | 0 | 10,847 | +10,847 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 5,471,299 | 5,481,666 | +10,367 | 1.23 | 1.15 | -0.09 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 67,572 | 77,689 | +10,117 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 253,630 | 262,935 | +9,305 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 43,668 | 52,122 | +8,454 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,277 | 65,963 | +6,686 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 25,782 | 32,314 | +6,532 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 2,407 | +2,407 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 156,983 | 159,052 | +2,069 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 57,367 | 59,003 | +1,636 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 95,577 | 96,816 | +1,239 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 3,087 | 3,982 | +895 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,627 | 16,516 | +889 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 26,236 | 27,075 | +839 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,604 | 4,395 | +791 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 781 | +781 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 44,734 | 45,481 | +747 | 0.00 | 0.00 | -0.00 | buy |
| Banque Transatlantique SA | 0 | 701 | +701 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 44 | 650 | +606 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 0 | 606 | +606 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 12,139 | 12,588 | +449 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 13 | 335 | +322 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,046 | 2,182 | +136 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 38,000 | 38,041 | +41 | 0.06 | 0.05 | -0.01 | buy |
| Amundi | 302 | 329 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,719 | 5,743 | +24 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 7,964,000 | 0 | 0.47 | 0.44 | -0.03 | hold |
| MAI Capital Management | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 7,047 | 7,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 86,465 | 86,465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 100,770 | 100,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 42,400 | 42,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 132,968 | 132,968 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 553 | 553 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 4.24 | 5.22 | +0.98 | hold |
| Swiss National Bank | 178,000 | 178,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rosalind Advisors, Inc. | 2,654,944 | 2,654,944 | 0 | 4.39 | 3.58 | -0.81 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 13,200 | 13,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 1,712 | 1,712 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cornerstone Planning Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 3.71 | 4.67 | +0.96 | hold |
| Police & Firemen's Retirement System of New Jersey | 26,223 | 26,223 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OPPENHEIMER & CO INC | 15,600 | 15,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 6,835,000 | 6,835,000 | 0 | 0.11 | 0.10 | -0.01 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 5 | 4 | -1 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 71 | 0 | -71 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 81 | 0 | -81 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 350 | 90 | -260 | 0.00 | 0.00 | -0.00 | sell |