| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.52 | 7.60 | +0.07 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 8.13 | 8.67 | +0.54 | hold |
| VR Adviser, LLC | 13,740,375 | 13,740,375 | 0 | 4.09 | 2.80 | -1.29 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,000 | 13,569,000 | 0 | 1.05 | 0.87 | -0.17 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 2.47 | 1.93 | -0.54 | hold |
| BlackRock, Inc. | 11,097,289 | 11,291,185 | +193,896 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 9,862,301 | 9,720,852 | -141,449 | 1.60 | 1.37 | -0.23 | sell |
| Polar Capital Holdings Plc | 8,306,196 | 9,541,786 | +1,235,590 | 0.23 | 0.23 | -0.00 | buy |
| Nantahala Capital Management, LLC | 7,344,783 | 7,344,783 | 0 | 2.64 | 2.50 | -0.14 | hold |
| STATE STREET CORP | 4,333,022 | 6,707,684 | +2,374,662 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 5,952,380 | 5,952,380 | 0 | 0.36 | 0.32 | -0.04 | hold |
| MARSHALL WACE, LLP | 4,559,921 | 4,514,348 | -45,573 | 0.03 | 0.03 | -0.00 | sell |
| Woodline Partners LP | 4,244,640 | 4,245,119 | +479 | 0.10 | 0.09 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,417,769 | 3,594,480 | +176,711 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 3,495,496 | 3,371,285 | -124,211 | 0.65 | 0.58 | -0.07 | sell |
| Rosalind Advisors, Inc. | 3,403,721 | 3,203,721 | -200,000 | 7.48 | 7.17 | -0.31 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 2,674,931 | 2,710,723 | +35,792 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 1,606,000 | 2,600,052 | +994,052 | 0.36 | 0.40 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 2,797,153 | 2,512,153 | -285,000 | 1.21 | 0.80 | -0.41 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,396,458 | 2,368,669 | -27,789 | 0.70 | 0.63 | -0.08 | sell |
| Pictet Asset Management Holding SA | 0 | 2,275,381 | +2,275,381 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 1,669,370 | 2,111,882 | +442,512 | 0.01 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 1,688,500 | 1,842,350 | +153,850 | 0.81 | 1.10 | +0.30 | buy |
| MORGAN STANLEY | 2,337,896 | 1,786,293 | -551,603 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 995,353 | 1,585,977 | +590,624 | 3.21 | 6.19 | +2.97 | buy |
| ADAR1 Capital Management, LLC | 1,405,452 | 1,464,535 | +59,083 | 0.63 | 0.48 | -0.15 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,430,982 | +1,430,982 | 0.00 | 0.92 | +0.92 | buy |
| Longaeva Partners L.P. | 1,246,042 | 1,275,000 | +28,958 | 0.89 | 0.33 | -0.56 | buy |
| NORTHERN TRUST CORP | 1,077,625 | 1,189,994 | +112,369 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,161,672 | 1,140,244 | -21,428 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,061,198 | 1,052,893 | -8,305 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 864,614 | +864,614 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 824,717 | 848,391 | +23,674 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 774,492 | 798,735 | +24,243 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 751,255 | 756,774 | +5,519 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,178,164 | 739,164 | -439,000 | 1.48 | 0.69 | -0.79 | sell |
| Swedbank AB | 850,000 | 700,000 | -150,000 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 332,100 | 652,672 | +320,572 | 0.00 | 0.01 | +0.00 | buy |
| F/m Investments LLC | 678,813 | 651,024 | -27,789 | 0.16 | 0.24 | +0.08 | sell |
| ORBIMED ADVISORS LLC | 0 | 635,000 | +635,000 | 0.00 | 0.08 | +0.08 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 614,279 | +614,279 | 0.00 | 0.60 | +0.60 | buy |
| Sio Capital Management, LLC | 613,888 | 613,888 | 0 | 0.61 | 0.48 | -0.13 | hold |
| Integral Health Asset Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.17 | +0.17 | buy |
| UBS Group AG | 202,883 | 596,715 | +393,832 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 423,596 | 588,199 | +164,603 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 516,598 | 580,059 | +63,461 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 463,002 | +463,002 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 584,289 | 430,967 | -153,322 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 170,195 | 384,264 | +214,069 | 0.06 | 0.14 | +0.08 | buy |
| XTX Topco Ltd | 24,680 | 379,402 | +354,722 | 0.00 | 0.04 | +0.03 | buy |
| Sofinnova Investments, Inc. | 304,770 | 364,763 | +59,993 | 0.08 | 0.10 | +0.02 | buy |
| Nuveen, LLC | 272,602 | 343,553 | +70,951 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 312,870 | 309,695 | -3,175 | 0.00 | 0.00 | -0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 0 | 307,998 | +307,998 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 0 | 250,999 | +250,999 | 0.00 | 0.38 | +0.38 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 31,204 | 240,600 | +209,396 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 688,595 | 223,010 | -465,585 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 205,090 | +205,090 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 150,084 | 195,077 | +44,993 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 89,858 | 188,954 | +99,096 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 170,819 | +170,819 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 152,775 | 157,142 | +4,367 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 83,089 | 153,147 | +70,058 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 0 | 136,800 | +136,800 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 127,040 | 127,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 74,882 | 122,862 | +47,980 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 114,198 | +114,198 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 69,536 | 101,472 | +31,936 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 140,753 | 93,726 | -47,027 | 0.07 | 0.03 | -0.04 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90,000 | 90,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 88,720 | +88,720 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 87,575 | +87,575 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 167,644 | 86,929 | -80,715 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 35,145 | 84,981 | +49,836 | 0.01 | 0.02 | +0.01 | buy |
| Optimize Financial Inc | 0 | 84,103 | +84,103 | 0.00 | 0.23 | +0.23 | buy |
| Cresset Asset Management, LLC | 83,334 | 83,484 | +150 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,014 | 81,286 | +10,272 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 73,059 | 80,709 | +7,650 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 40,716 | 73,881 | +33,165 | 0.10 | 0.12 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 543,756 | 71,599 | -472,157 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 78,551 | 69,449 | -9,102 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 27,849 | 69,031 | +41,182 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,547 | 68,175 | +24,628 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 66,428 | +66,428 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 59,469 | 59,974 | +505 | 0.01 | 0.00 | -0.00 | buy |
| Creative Planning | 55,719 | 59,829 | +4,110 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 45,526 | 57,400 | +11,874 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 55,177 | +55,177 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 52,718 | +52,718 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 48,507 | 48,500 | -7 | 0.06 | 0.05 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 46,854 | +46,854 | 0.00 | 0.00 | +0.00 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 46,000 | 46,000 | 0 | 0.06 | 0.06 | -0.01 | hold |
| JANUS HENDERSON GROUP PLC | 0 | 45,200 | +45,200 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 44,791 | +44,791 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 14,709 | 44,569 | +29,860 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 43,376 | +43,376 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 33,925 | 40,637 | +6,712 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 188,214 | 40,017 | -148,197 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 0 | 39,858 | +39,858 | 0.00 | 0.20 | +0.20 | buy |
| Virtus Investment Advisers, LLC | 38,443 | 39,405 | +962 | 0.06 | 0.06 | -0.00 | buy |