| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.56 | 7.42 | -0.14 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,565,457 | 14,565,457 | 0 | 5.83 | 6.44 | +0.61 | hold |
| TCG Crossover Management, LLC | 10,000,000 | 12,362,205 | +2,362,205 | 3.94 | 5.19 | +1.26 | buy |
| Frazier Life Sciences Management, L.P. | 4,000,000 | 8,157,385 | +4,157,385 | 0.84 | 1.54 | +0.70 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,779,186 | 7,015,490 | +4,236,304 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,287,930 | 6,987,930 | -1,300,000 | 0.08 | 0.05 | -0.03 | sell |
| VANGUARD GROUP INC | 6,063,620 | 6,638,758 | +575,138 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 6,490,000 | +6,490,000 | 0.00 | 1.95 | +1.95 | buy |
| JENNISON ASSOCIATES LLC | 8,841,971 | 5,731,480 | -3,110,491 | 0.03 | 0.01 | -0.01 | sell |
| Sofinnova Investments, Inc. | 2,347,261 | 5,358,918 | +3,011,657 | 0.69 | 1.36 | +0.67 | buy |
| Nantahala Capital Management, LLC | 1,737,410 | 5,180,951 | +3,443,541 | 0.85 | 2.10 | +1.25 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,394,299 | 4,560,000 | +2,165,701 | 0.07 | 0.11 | +0.04 | buy |
| STATE STREET CORP | 1,880,064 | 3,578,034 | +1,697,970 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 1,085,666 | 2,820,316 | +1,734,650 | 0.07 | 0.12 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,367,805 | 2,462,025 | +94,220 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,563,620 | 2,276,460 | -287,160 | 0.01 | 0.00 | -0.00 | sell |
| First Light Asset Management, LLC | 0 | 2,002,219 | +2,002,219 | 0.00 | 0.71 | +0.71 | buy |
| Altium Capital Management LLC | 1,335,000 | 1,575,000 | +240,000 | 2.97 | 2.62 | -0.35 | buy |
| Affinity Asset Advisors, LLC | 1,150,000 | 1,546,850 | +396,850 | 0.93 | 0.98 | +0.05 | buy |
| AXA S.A. | 1,330,435 | 1,051,135 | -279,300 | 0.02 | 0.01 | -0.01 | sell |
| FMR LLC | 2,015 | 988,739 | +986,724 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 962,687 | +962,687 | 0.00 | 0.63 | +0.63 | buy |
| NORTHERN TRUST CORP | 803,159 | 791,897 | -11,262 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 753,885 | 782,098 | +28,213 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 855,000 | 714,960 | -140,040 | 0.93 | 0.66 | -0.27 | sell |
| PRUDENTIAL FINANCIAL INC | 1,137,845 | 675,895 | -461,950 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 5,600 | 663,598 | +657,998 | 0.01 | 0.54 | +0.53 | buy |
| Schonfeld Strategic Advisors LLC | 177,100 | 646,668 | +469,568 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 562,186 | 529,579 | -32,607 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 392,723 | 448,360 | +55,637 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 499,115 | 404,215 | -94,900 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 58,593 | 304,700 | +246,107 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 256,183 | 288,325 | +32,142 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 144,880 | 287,441 | +142,561 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,575 | 269,358 | +26,783 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 231,564 | 257,325 | +25,761 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 197,430 | 238,807 | +41,377 | 0.04 | 0.03 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 169,225 | 208,549 | +39,324 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 2,065,144 | 200,000 | -1,865,144 | 6.80 | 1.02 | -5.78 | sell |
| CITADEL ADVISORS LLC | 0 | 161,007 | +161,007 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 120,941 | 152,123 | +31,182 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 147,000 | 147,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 138,211 | 138,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 0 | 135,640 | +135,640 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 133,929 | 134,548 | +619 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 130,830 | +130,830 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 108,687 | 126,034 | +17,347 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 17,300 | 119,674 | +102,374 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 79,073 | 115,831 | +36,758 | 0.02 | 0.01 | -0.01 | buy |
| CITIGROUP INC | 17,320 | 112,818 | +95,498 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 112,238 | +112,238 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 95,462 | 107,777 | +12,315 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 1,025,839 | 102,536 | -923,303 | 0.06 | 0.00 | -0.05 | sell |
| ALLIANCEBERNSTEIN L.P. | 34,100 | 100,770 | +66,670 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 100,737 | +100,737 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| AWM Investment Company, Inc. | 100,000 | 90,500 | -9,500 | 0.07 | 0.05 | -0.02 | sell |
| JANE STREET GROUP, LLC | 85,849 | 88,566 | +2,717 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 85,061 | 83,474 | -1,587 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,986 | 76,329 | +343 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 15,887 | 72,171 | +56,284 | 0.07 | 0.14 | +0.06 | buy |
| Legal & General Group Plc | 64,014 | 69,412 | +5,398 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 78,071 | 67,961 | -10,110 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 17,190 | 62,411 | +45,221 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,002 | 53,640 | -1,362 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 53,403 | +53,403 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,548 | 52,174 | -36,374 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 39,811 | 52,024 | +12,213 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,122 | 44,008 | +39,886 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 87,437 | 43,978 | -43,459 | 0.01 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 43,211 | 43,108 | -103 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,915 | 41,250 | +5,335 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 10,551 | 41,059 | +30,508 | 0.01 | 0.01 | +0.01 | buy |
| Sivia Capital Partners, LLC | 37,500 | 39,000 | +1,500 | 0.13 | 0.11 | -0.02 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 36,274 | +36,274 | 0.00 | 0.03 | +0.03 | buy |
| SIMPLEX TRADING, LLC | 10,019 | 35,357 | +25,338 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,665 | 33,335 | -330 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,692 | 30,984 | -2,708 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,458 | 30,739 | +281 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 29,415 | +29,415 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 27,833 | +27,833 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 26,017 | +26,017 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 25,782 | 25,782 | 0 | 0.01 | 0.01 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 25,780 | +25,780 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 22,800 | 22,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 0 | 22,297 | +22,297 | 0.00 | 0.04 | +0.04 | buy |
| Arizona State Retirement System | 20,469 | 21,275 | +806 | 0.00 | 0.00 | -0.00 | buy |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 25,715 | 20,630 | -5,085 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,822 | 17,795 | +6,973 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 16,900 | +16,900 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16,583 | 16,693 | +110 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,192 | 16,483 | -4,709 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 26,035 | 16,235 | -9,800 | 0.02 | 0.01 | -0.01 | sell |
| DRW Securities, LLC | 0 | 15,492 | +15,492 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 14,862 | +14,862 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 2,142 | 14,769 | +12,627 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 0 | 14,658 | +14,658 | 0.00 | 0.00 | +0.00 | buy |