| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 4,000,000 | 8,157,385 | +4,157,385 | 0.84 | 1.54 | +0.70 | buy |
| Nantahala Capital Management, LLC | 1,737,410 | 5,180,951 | +3,443,541 | 0.49 | 1.22 | +0.73 | buy |
| Sofinnova Investments, Inc. | 2,347,261 | 5,358,918 | +3,011,657 | 0.65 | 1.12 | +0.47 | buy |
| TCG Crossover Management, LLC | 10,000,000 | 12,362,205 | +2,362,205 | 3.94 | 5.19 | +1.26 | buy |
| ExodusPoint Capital Management, LP | 1,085,666 | 2,820,316 | +1,734,650 | 0.07 | 0.13 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 5,600 | 663,598 | +657,998 | 0.01 | 0.54 | +0.53 | buy |
| Affinity Asset Advisors, LLC | 1,150,000 | 1,546,850 | +396,850 | 0.93 | 0.98 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 2,563,620 | 2,276,460 | +287,160 | 0.01 | 0.00 | 0.00 | sell |
| Altium Capital Management LLC | 1,335,000 | 1,575,000 | +240,000 | 2.97 | 2.62 | -0.35 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 392,723 | 448,360 | +55,637 | 0.01 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 87,437 | 43,978 | +43,459 | 0.03 | 0.01 | 0.00 | sell |
| ALGERT GLOBAL LLC | 197,430 | 238,807 | +41,377 | 0.04 | 0.03 | 0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 79,073 | 115,831 | +36,758 | 0.02 | 0.01 | -0.01 | buy |
| ALPS ADVISORS INC | 95,462 | 107,777 | +12,315 | 0.00 | 0.00 | -0.00 | buy |
| Sivia Capital Partners, LLC | 37,500 | 39,000 | +1,500 | 0.13 | 0.11 | -0.02 | buy |
| AWM Investment Company, Inc. | 100,000 | 90,500 | -9,500 | 0.07 | 0.05 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 26,035 | 16,235 | -9,800 | 0.02 | 0.01 | -0.01 | sell |
| Opaleye Management Inc. | 855,000 | 714,960 | -140,040 | 0.93 | 0.66 | -0.27 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,287,930 | 6,987,930 | -1,300,000 | 0.08 | 0.05 | -0.03 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 2,065,144 | 200,000 | -1,865,144 | 6.80 | 1.02 | -5.78 | sell |
| JENNISON ASSOCIATES LLC | 8,841,971 | 5,731,480 | -3,110,491 | 0.03 | 0.01 | -0.01 | sell |