| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 5.22 | 4.20 | -1.02 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 7.21 | 5.02 | -2.19 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 4.67 | 3.22 | -1.45 | hold |
| Frazier Life Sciences Management, L.P. | 11,462,301 | 11,462,301 | 0 | 1.45 | 1.05 | -0.41 | hold |
| Vestal Point Capital, LP | 11,000,000 | 11,015,000 | +15,000 | 2.18 | 1.32 | -0.85 | buy |
| BlackRock, Inc. | 9,946,311 | 9,775,573 | -170,738 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 3,257,639 | 8,884,263 | +5,626,624 | 0.77 | 1.52 | +0.75 | buy |
| VANGUARD GROUP INC | 8,119,247 | 8,453,980 | +334,733 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 8,075,375 | 8,325,375 | +250,000 | 1.85 | 1.34 | -0.51 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 7,964,000 | 0 | 0.44 | 0.33 | -0.11 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 6,835,000 | 6,835,000 | 0 | 0.10 | 0.07 | -0.03 | hold |
| ADAR1 Capital Management, LLC | 1,360,291 | 3,600,670 | +2,240,379 | 0.73 | 1.33 | +0.61 | buy |
| EMERALD ADVISERS, LLC | 3,090,213 | 3,534,368 | +444,155 | 0.39 | 0.30 | -0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,162,653 | 3,350,272 | -812,381 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,822,237 | 2,970,183 | +147,946 | 0.00 | 0.00 | -0.00 | buy |
| Rosalind Advisors, Inc. | 2,654,944 | 2,654,944 | 0 | 3.58 | 2.93 | -0.65 | hold |
| Sofinnova Investments, Inc. | 5,481,666 | 2,457,352 | -3,024,314 | 1.15 | 0.38 | -0.76 | sell |
| STATE STREET CORP | 2,449,651 | 2,456,941 | +7,290 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,014,456 | 2,186,404 | +171,948 | 0.40 | 0.30 | -0.09 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,284,151 | 1,310,233 | +26,082 | 0.88 | 0.78 | -0.10 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 966,203 | 1,115,379 | +149,176 | 3.19 | 3.17 | -0.02 | buy |
| NORTHERN TRUST CORP | 1,056,178 | 1,069,656 | +13,478 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 1,048,441 | 1,050,126 | +1,685 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 954,830 | 995,511 | +40,681 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 916,017 | 831,045 | -84,972 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 81,029 | 797,118 | +716,089 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 719,654 | 726,851 | +7,197 | 0.60 | 0.67 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 87,705 | 708,463 | +620,758 | 0.02 | 0.11 | +0.09 | buy |
| DIMENSIONAL FUND ADVISORS LP | 288,674 | 645,472 | +356,798 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 467,547 | 530,078 | +62,531 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 797,327 | 526,162 | -271,165 | 0.01 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.17 | +0.17 | buy |
| Nuveen, LLC | 385,103 | 320,273 | -64,830 | 0.00 | 0.00 | -0.00 | sell |
| F/m Investments LLC | 223,016 | 314,846 | +91,830 | 0.02 | 0.03 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 778,954 | 309,835 | -469,119 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 405,604 | 282,764 | -122,840 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 262,935 | 269,487 | +6,552 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 161,483 | 253,828 | +92,345 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 159,052 | 221,669 | +62,617 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 184,257 | 216,611 | +32,354 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 263,715 | 199,315 | -64,400 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 182,296 | +182,296 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 181,655 | 178,500 | -3,155 | 0.23 | 0.20 | -0.03 | sell |
| RHUMBLINE ADVISERS | 153,542 | 170,176 | +16,634 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,629 | 160,079 | +10,450 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 251,912 | 155,860 | -96,052 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 60,343 | 149,427 | +89,084 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 178,000 | 148,400 | -29,600 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 100,770 | 137,090 | +36,320 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 213,714 | 123,358 | -90,356 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 89,258 | 120,891 | +31,633 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 504,011 | 110,784 | -393,227 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 137,694 | 110,000 | -27,694 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 88,097 | +88,097 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 86,465 | 86,465 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stonepine Capital Management, LLC | 29,079 | 85,000 | +55,921 | 0.08 | 0.19 | +0.11 | buy |
| ALGERT GLOBAL LLC | 132,968 | 79,948 | -53,020 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 56,260 | 79,713 | +23,453 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 23,611 | 77,911 | +54,300 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 65,963 | 77,891 | +11,928 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 52,102 | 75,633 | +23,531 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71,224 | 69,845 | -1,379 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 77,689 | 69,167 | -8,522 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 2,183,660 | 68,508 | -2,115,152 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 93,889 | 56,001 | -37,888 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 52,122 | 55,667 | +3,545 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 96,816 | 54,697 | -42,119 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 93,082 | 53,178 | -39,904 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 45,481 | 51,930 | +6,449 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 42,400 | 42,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 49,006 | 41,607 | -7,399 | 0.04 | 0.03 | -0.00 | sell |
| Sivia Capital Partners, LLC | 38,041 | 41,500 | +3,459 | 0.05 | 0.03 | -0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 39,839 | +39,839 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 32,314 | 38,001 | +5,687 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 34,424 | 34,714 | +290 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 33,815 | 32,398 | -1,417 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 30,395 | +30,395 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 26,223 | 26,223 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arizona State Retirement System | 27,075 | 22,626 | -4,449 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 25,370 | 21,351 | -4,019 | 0.00 | 0.00 | -0.00 | sell |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 0 | 18,459 | +18,459 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 7,000 | 17,000 | +10,000 | 0.00 | 0.01 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 26,724 | 15,589 | -11,135 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 15,600 | 15,500 | -100 | 0.00 | 0.00 | -0.00 | sell |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 14,580 | +14,580 | 0.00 | 0.00 | +0.00 | buy |
| May Hill Capital, LLC | 0 | 14,097 | +14,097 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 8,847 | 13,473 | +4,626 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 13,200 | 13,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 12,995 | +12,995 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 11,833 | +11,833 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,663 | 8,686 | +6,023 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,047 | 7,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 5,743 | 6,677 | +934 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 13,082 | 5,651 | -7,431 | 0.00 | 0.00 | -0.00 | sell |