| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 635,000 | 3,959,900 | +3,324,900 | 0.08 | 0.46 | +0.39 | buy |
| MARSHALL WACE, LLP | 4,514,348 | 6,256,989 | +1,742,641 | 0.03 | 0.03 | +0.01 | buy |
| BlackRock, Inc. | 11,291,185 | 12,494,498 | +1,203,313 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,170,747 | +1,170,747 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 13,740,375 | 14,745,943 | +1,005,568 | 2.80 | 2.75 | -0.05 | buy |
| Pictet Asset Management Holding SA | 2,275,381 | 2,763,055 | +487,674 | 0.01 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 864,614 | 1,329,259 | +464,645 | 0.07 | 0.10 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 410,609 | +410,609 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 2,111,882 | 2,514,998 | +403,116 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,594,480 | 3,872,133 | +277,653 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 580,059 | 829,345 | +249,286 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 142,793 | +142,793 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 32,292 | 159,884 | +127,592 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 2,600,052 | 2,720,000 | +119,948 | 0.40 | 0.39 | -0.01 | buy |
| NORTHERN TRUST CORP | 1,189,994 | 1,302,905 | +112,911 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 69,031 | 174,738 | +105,707 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.16 | +0.16 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,917 | 100,936 | +93,019 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 86,929 | 179,563 | +92,634 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 80,000 | +80,000 | 0.00 | 0.23 | +0.23 | buy |
| Russell Investments Group, Ltd. | 10,797 | 89,875 | +79,078 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 69,638 | +69,638 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,718 | 116,222 | +63,504 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 309,695 | 372,367 | +62,672 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 195,077 | 248,720 | +53,643 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,854 | 95,117 | +48,263 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 136,800 | 185,000 | +48,200 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 44,400 | +44,400 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,135 | 65,816 | +32,681 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 31,447 | +31,447 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,140,244 | 1,170,747 | +30,503 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 157,142 | 186,071 | +28,929 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 24,560 | +24,560 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,215 | 37,647 | +24,432 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 101,472 | 125,676 | +24,204 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 33,613 | 56,951 | +23,338 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 39,405 | 62,205 | +22,800 | 0.06 | 0.09 | +0.03 | buy |
| Quantinno Capital Management LP | 0 | 21,630 | +21,630 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 69,449 | 89,256 | +19,807 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 739,164 | 756,164 | +17,000 | 0.69 | 0.67 | -0.03 | buy |
| DEUTSCHE BANK AG\ | 848,391 | 864,956 | +16,565 | 0.00 | 0.00 | +0.00 | buy |
| Swedbank AB | 700,000 | 715,900 | +15,900 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 11,940 | +11,940 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 0 | 11,278 | +11,278 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 0 | 10,488 | +10,488 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 10,319 | +10,319 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 10,161 | +10,161 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 27,874 | 37,350 | +9,476 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 23,119 | 32,051 | +8,932 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,555 | 45,455 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,368,669 | 2,375,999 | +7,330 | 0.63 | 0.51 | -0.11 | buy |
| F/m Investments LLC | 651,024 | 658,354 | +7,330 | 0.24 | 0.21 | -0.03 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 6,765 | +6,765 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,989 | 25,445 | +6,456 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 23,627 | 29,817 | +6,190 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 26,500 | 32,400 | +5,900 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 80,709 | 85,909 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 57,400 | 61,977 | +4,577 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 613,888 | 617,675 | +3,787 | 0.48 | 0.65 | +0.17 | buy |
| Susquehanna Portfolio Strategies, LLC | 59,974 | 63,078 | +3,104 | 0.00 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,495 | 13,885 | +2,390 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 22,175 | 24,555 | +2,380 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 12,746 | 14,634 | +1,888 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,175 | 69,885 | +1,710 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 11,545 | 13,239 | +1,694 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 59,829 | 61,518 | +1,689 | 0.00 | 0.00 | -0.00 | buy |
| OPPENHEIMER & CO INC | 15,500 | 17,000 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,484 | +1,484 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,358 | 11,698 | +1,340 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,914 | 12,329 | +415 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 399 | 701 | +302 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,473 | 1,760 | +287 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 136 | 409 | +273 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 26,903 | 27,056 | +153 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 117 | +117 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 205 | 276 | +71 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 22 | 74 | +52 | 0.00 | 0.00 | 0.00 | buy |
| EverSource Wealth Advisors, LLC | 12 | 47 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 26,421 | 26,426 | +5 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 3 | 6 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,000 | 13,569,000 | 0 | 0.87 | 0.87 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205,090 | 205,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 127,040 | 127,040 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 5,952,380 | 5,952,380 | 0 | 0.32 | 0.31 | -0.01 | hold |
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.60 | 9.49 | +1.90 | hold |
| Sofinnova Investments, Inc. | 364,763 | 364,763 | 0 | 0.10 | 0.12 | +0.02 | hold |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 46,000 | 46,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 8.67 | 6.45 | -2.22 | hold |
| KLP KAPITALFORVALTNING AS | 15,200 | 15,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Affinity Asset Advisors, LLC | 2,512,153 | 2,512,153 | 0 | 0.80 | 0.76 | -0.05 | hold |
| Integral Health Asset Management, LLC | 600,000 | 600,000 | 0 | 0.17 | 0.15 | -0.02 | hold |
| NAN FUNG TRINITY (HK) Ltd | 1,842,350 | 1,842,350 | 0 | 1.10 | 1.12 | +0.02 | hold |
| Woodline Partners LP | 4,245,119 | 4,245,119 | 0 | 0.09 | 0.08 | -0.01 | hold |