| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.60 | 9.49 | +1.90 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 8.67 | 6.45 | -2.22 | hold |
| VR Adviser, LLC | 13,740,375 | 14,745,943 | +1,005,568 | 2.80 | 2.75 | -0.05 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 13,569,000 | 13,569,000 | 0 | 0.87 | 0.87 | -0.00 | hold |
| BlackRock, Inc. | 11,291,185 | 12,494,498 | +1,203,313 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 1.93 | 1.83 | -0.10 | hold |
| Frazier Life Sciences Management, L.P. | 9,720,852 | 9,720,852 | 0 | 1.37 | 1.30 | -0.06 | hold |
| Polar Capital Holdings Plc | 9,541,786 | 9,541,786 | 0 | 0.23 | 0.17 | -0.06 | hold |
| Nantahala Capital Management, LLC | 7,344,783 | 6,976,810 | -367,973 | 2.50 | 2.60 | +0.09 | sell |
| STATE STREET CORP | 6,707,684 | 6,553,348 | -154,336 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 4,514,348 | 6,256,989 | +1,742,641 | 0.03 | 0.03 | +0.01 | buy |
| RTW INVESTMENTS, LP | 5,952,380 | 5,952,380 | 0 | 0.32 | 0.31 | -0.01 | hold |
| Woodline Partners LP | 4,245,119 | 4,245,119 | 0 | 0.09 | 0.08 | -0.01 | hold |
| ORBIMED ADVISORS LLC | 635,000 | 3,959,900 | +3,324,900 | 0.08 | 0.46 | +0.39 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,594,480 | 3,872,133 | +277,653 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 3,203,721 | 3,178,121 | -25,600 | 7.17 | 7.35 | +0.19 | sell |
| EMERALD ADVISERS, LLC | 3,371,285 | 3,148,439 | -222,846 | 0.58 | 0.46 | -0.13 | sell |
| Pictet Asset Management Holding SA | 2,275,381 | 2,763,055 | +487,674 | 0.01 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 2,600,052 | 2,720,000 | +119,948 | 0.40 | 0.39 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,710,723 | 2,694,812 | -15,911 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 2,111,882 | 2,514,998 | +403,116 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 2,512,153 | 2,512,153 | 0 | 0.80 | 0.76 | -0.05 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,368,669 | 2,375,999 | +7,330 | 0.63 | 0.51 | -0.11 | buy |
| NAN FUNG TRINITY (HK) Ltd | 1,842,350 | 1,842,350 | 0 | 1.10 | 1.12 | +0.02 | hold |
| ADAR1 Capital Management, LLC | 1,464,535 | 1,403,409 | -61,126 | 0.48 | 0.41 | -0.07 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,430,982 | 1,355,459 | -75,523 | 0.92 | 0.93 | +0.01 | sell |
| ALGERT GLOBAL LLC | 864,614 | 1,329,259 | +464,645 | 0.07 | 0.10 | +0.03 | buy |
| NORTHERN TRUST CORP | 1,189,994 | 1,302,905 | +112,911 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,170,747 | +1,170,747 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,140,244 | 1,170,747 | +30,503 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 1,275,000 | 1,015,887 | -259,113 | 0.33 | 0.18 | -0.15 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,052,893 | 1,009,691 | -43,202 | 0.01 | 0.01 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,585,977 | 977,460 | -608,517 | 6.19 | 3.80 | -2.38 | sell |
| DEUTSCHE BANK AG\ | 848,391 | 864,956 | +16,565 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 580,059 | 829,345 | +249,286 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 739,164 | 756,164 | +17,000 | 0.69 | 0.67 | -0.03 | buy |
| Swedbank AB | 700,000 | 715,900 | +15,900 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 756,774 | 692,211 | -64,563 | 0.00 | 0.00 | -0.00 | sell |
| F/m Investments LLC | 651,024 | 658,354 | +7,330 | 0.24 | 0.21 | -0.03 | buy |
| Sio Capital Management, LLC | 613,888 | 617,675 | +3,787 | 0.48 | 0.65 | +0.17 | buy |
| Integral Health Asset Management, LLC | 600,000 | 600,000 | 0 | 0.17 | 0.15 | -0.02 | hold |
| BANK OF AMERICA CORP /DE/ | 588,199 | 520,356 | -67,843 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 596,715 | 513,026 | -83,689 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 614,279 | 482,793 | -131,486 | 0.60 | 0.53 | -0.07 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 410,609 | +410,609 | 0.00 | 0.05 | +0.05 | buy |
| Bank of New York Mellon Corp | 309,695 | 372,367 | +62,672 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,786,293 | 365,966 | -1,420,327 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 364,763 | 364,763 | 0 | 0.10 | 0.12 | +0.02 | hold |
| Nuveen, LLC | 343,553 | 339,319 | -4,234 | 0.00 | 0.00 | -0.00 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 307,998 | 294,215 | -13,783 | 0.03 | 0.03 | -0.00 | sell |
| CITADEL ADVISORS LLC | 798,735 | 261,047 | -537,688 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 652,672 | 248,889 | -403,783 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 195,077 | 248,720 | +53,643 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 250,999 | 242,379 | -8,620 | 0.38 | 0.34 | -0.04 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 205,090 | 205,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eversept Partners, LP | 384,264 | 204,428 | -179,836 | 0.14 | 0.07 | -0.07 | sell |
| Invesco Ltd. | 223,010 | 200,685 | -22,325 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 157,142 | 186,071 | +28,929 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 136,800 | 185,000 | +48,200 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 86,929 | 179,563 | +92,634 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 69,031 | 174,738 | +105,707 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 32,292 | 159,884 | +127,592 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 142,793 | +142,793 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 127,040 | 127,040 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 101,472 | 125,676 | +24,204 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 379,402 | 122,510 | -256,892 | 0.04 | 0.01 | -0.03 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,718 | 116,222 | +63,504 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,917 | 100,936 | +93,019 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.16 | +0.16 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,854 | 95,117 | +48,263 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90,000 | 90,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 10,797 | 89,875 | +79,078 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 69,449 | 89,256 | +19,807 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 188,954 | 88,844 | -100,110 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 88,720 | 86,288 | -2,432 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 80,709 | 85,909 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 84,103 | 83,811 | -292 | 0.23 | 0.19 | -0.04 | sell |
| Cresset Asset Management, LLC | 83,484 | 83,334 | -150 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 81,286 | 80,471 | -815 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 0 | 80,000 | +80,000 | 0.00 | 0.23 | +0.23 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 122,862 | 74,876 | -47,986 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,175 | 69,885 | +1,710 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 69,638 | +69,638 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,135 | 65,816 | +32,681 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 59,974 | 63,078 | +3,104 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 39,405 | 62,205 | +22,800 | 0.06 | 0.09 | +0.03 | buy |
| SG Americas Securities, LLC | 57,400 | 61,977 | +4,577 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 59,829 | 61,518 | +1,689 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 33,613 | 56,951 | +23,338 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 66,428 | 54,155 | -12,273 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| Sivia Capital Partners, LLC | 48,500 | 48,500 | 0 | 0.05 | 0.04 | -0.02 | hold |
| PROFUND ADVISORS LLC | 84,981 | 46,371 | -38,610 | 0.02 | 0.01 | -0.01 | sell |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 46,000 | 46,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,555 | 45,455 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 44,400 | +44,400 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 44,569 | 43,429 | -1,140 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 40,637 | 40,637 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 55,177 | 40,242 | -14,935 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,215 | 37,647 | +24,432 | 0.00 | 0.00 | +0.00 | buy |