| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.42 | 5.65 | -1.77 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,565,457 | 14,565,457 | 0 | 6.44 | 6.43 | -0.02 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 5.19 | 4.44 | -0.75 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 7,015,490 | 8,624,012 | +1,608,522 | 0.01 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 8,157,385 | 8,157,385 | 0 | 1.54 | 1.39 | -0.15 | hold |
| Vestal Point Capital, LP | 6,490,000 | 8,090,000 | +1,600,000 | 1.95 | 2.71 | +0.76 | buy |
| VANGUARD GROUP INC | 6,638,758 | 7,944,011 | +1,305,253 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,987,930 | 6,753,701 | -234,229 | 0.05 | 0.05 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 5,731,480 | 6,732,776 | +1,001,296 | 0.01 | 0.02 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 6,465,777 | +6,465,777 | 0.00 | 0.41 | +0.41 | buy |
| Sofinnova Investments, Inc. | 5,358,918 | 5,662,550 | +303,632 | 1.36 | 1.99 | +0.63 | buy |
| Nantahala Capital Management, LLC | 5,180,951 | 5,180,951 | 0 | 2.10 | 1.85 | -0.25 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 4,560,000 | 4,560,000 | 0 | 0.11 | 0.11 | -0.00 | hold |
| STATE STREET CORP | 3,578,034 | 4,138,276 | +560,242 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 2,820,316 | 2,794,476 | -25,840 | 0.12 | 0.12 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,462,025 | 2,726,850 | +264,825 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 2,305,195 | +2,305,195 | 0.00 | 0.08 | +0.08 | buy |
| Altium Capital Management LLC | 1,575,000 | 1,575,000 | 0 | 2.62 | 1.99 | -0.63 | hold |
| FMR LLC | 988,739 | 1,083,893 | +95,154 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 1,051,135 | 1,051,432 | +297 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 791,897 | 987,790 | +195,893 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 269,358 | 911,617 | +642,259 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 782,098 | 874,541 | +92,443 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 663,598 | 742,634 | +79,036 | 0.54 | 0.53 | -0.01 | buy |
| Affinity Asset Advisors, LLC | 1,546,850 | 700,000 | -846,850 | 0.98 | 0.46 | -0.52 | sell |
| GOLDMAN SACHS GROUP INC | 287,441 | 696,807 | +409,366 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 448,360 | 690,609 | +242,249 | 0.01 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 675,895 | 677,475 | +1,580 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 529,579 | 657,849 | +128,270 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 962,687 | 563,107 | -399,580 | 0.63 | 0.39 | -0.24 | sell |
| MORGAN STANLEY | 257,325 | 471,355 | +214,030 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 376,800 | +376,800 | 0.00 | 0.80 | +0.80 | buy |
| Schonfeld Strategic Advisors LLC | 646,668 | 373,080 | -273,588 | 0.02 | 0.01 | -0.01 | sell |
| CITADEL ADVISORS LLC | 161,007 | 316,189 | +155,182 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 404,215 | 289,915 | -114,300 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 208,549 | 283,242 | +74,693 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 29,415 | 280,664 | +251,249 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,276,460 | 245,800 | -2,030,660 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 288,325 | 235,760 | -52,565 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 67,961 | 231,005 | +163,044 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 200,000 | 200,000 | 0 | 1.02 | 0.76 | -0.26 | hold |
| Swiss National Bank | 147,000 | 190,800 | +43,800 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 126,034 | 170,079 | +44,045 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 135,640 | 168,125 | +32,485 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 130,830 | 140,010 | +9,180 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 138,211 | 138,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 53,403 | 132,425 | +79,022 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 134,548 | 132,384 | -2,164 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 107,777 | 128,501 | +20,724 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,674 | 125,815 | +6,141 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 238,807 | 123,968 | -114,839 | 0.03 | 0.01 | -0.02 | sell |
| OPPENHEIMER & CO INC | 100,737 | 115,604 | +14,867 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 62,411 | 114,495 | +52,084 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,770 | 100,770 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 69,412 | 95,577 | +26,165 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 76,329 | 94,567 | +18,238 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 36,274 | 92,521 | +56,247 | 0.03 | 0.07 | +0.05 | buy |
| CITIGROUP INC | 112,818 | 86,330 | -26,488 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 83,474 | 83,451 | -23 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,663 | 69,788 | +19,125 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 69,490 | +69,490 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 52,024 | 66,907 | +14,883 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 88,566 | 64,919 | -23,647 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 52,168 | 61,697 | +9,529 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 53,895 | +53,895 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 43,108 | 46,958 | +3,850 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 45,259 | +45,259 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,250 | 44,956 | +3,706 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 112,238 | 44,095 | -68,143 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 44,008 | 44,008 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 33,335 | 41,491 | +8,156 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 41,017 | +41,017 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 72,171 | 40,963 | -31,208 | 0.14 | 0.10 | -0.04 | sell |
| Sivia Capital Partners, LLC | 39,000 | 40,500 | +1,500 | 0.11 | 0.10 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 43,978 | 38,482 | -5,496 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 30,984 | 38,432 | +7,448 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,174 | 37,509 | -14,665 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 100,000 | 36,800 | -63,200 | 0.01 | 0.00 | -0.01 | sell |
| PROFUND ADVISORS LLC | 26,017 | 34,215 | +8,198 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,235 | 31,658 | +15,423 | 0.01 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 20,630 | 31,531 | +10,901 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 21,275 | 28,406 | +7,131 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 25,782 | 25,782 | 0 | 0.01 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 7,159 | 25,693 | +18,534 | 0.00 | 0.00 | +0.00 | buy |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16,693 | 24,743 | +8,050 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 22,297 | 22,701 | +404 | 0.04 | 0.05 | +0.00 | buy |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 0 | 17,013 | +17,013 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 15,853 | +15,853 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,739 | 13,855 | -16,884 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 12,836 | 12,157 | -679 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 9,054 | 11,689 | +2,635 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 10,802 | +10,802 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 17,795 | 10,188 | -7,607 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 9,610 | +9,610 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 8,686 | +8,686 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,047 | 7,047 | 0 | 0.00 | 0.00 | -0.00 | hold |