| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 4.20 | 4.79 | +0.59 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 5.02 | 4.17 | -0.85 | hold |
| VR Adviser, LLC | 8,884,263 | 12,681,043 | +3,796,780 | 1.52 | 2.55 | +1.03 | buy |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 3.22 | 2.17 | -1.05 | hold |
| Frazier Life Sciences Management, L.P. | 11,462,301 | 11,462,301 | 0 | 1.05 | 1.23 | +0.18 | hold |
| Nantahala Capital Management, LLC | 8,325,375 | 8,775,375 | +450,000 | 1.34 | 1.93 | +0.59 | buy |
| BlackRock, Inc. | 9,775,573 | 8,448,240 | -1,327,333 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 8,453,980 | 8,313,194 | -140,786 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 7,964,000 | 0 | 0.33 | 0.44 | +0.11 | hold |
| Vestal Point Capital, LP | 11,015,000 | 4,015,000 | -7,000,000 | 1.32 | 0.65 | -0.67 | sell |
| Rosalind Advisors, Inc. | 2,654,944 | 4,000,000 | +1,345,056 | 2.93 | 5.05 | +2.12 | buy |
| EMERALD ADVISERS, LLC | 3,534,368 | 3,529,324 | -5,044 | 0.30 | 0.40 | +0.11 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,970,183 | 2,795,661 | -174,522 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,350,272 | 2,644,000 | -706,272 | 0.00 | 0.00 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 6,835,000 | 2,500,000 | -4,335,000 | 0.07 | 0.05 | -0.02 | sell |
| Sofinnova Investments, Inc. | 2,457,352 | 2,427,724 | -29,628 | 0.38 | 0.53 | +0.15 | sell |
| STATE STREET CORP | 2,456,941 | 2,359,858 | -97,083 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,186,404 | 2,151,358 | -35,046 | 0.30 | 0.40 | +0.09 | sell |
| ADAR1 Capital Management, LLC | 3,600,670 | 1,988,288 | -1,612,382 | 1.33 | 0.70 | -0.63 | sell |
| MORGAN STANLEY | 0 | 1,917,827 | +1,917,827 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 1,500,000 | +1,000,000 | 0.17 | 0.50 | +0.33 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,310,233 | 1,350,333 | +40,100 | 0.78 | 1.14 | +0.36 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,115,379 | 1,309,236 | +193,857 | 3.17 | 4.60 | +1.44 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 995,511 | 963,798 | -31,713 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,069,656 | 946,732 | -122,924 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 797,118 | 856,600 | +59,482 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 831,045 | 850,978 | +19,933 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 844,177 | +844,177 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 726,851 | 726,851 | 0 | 0.67 | 0.66 | -0.01 | hold |
| DIMENSIONAL FUND ADVISORS LP | 645,472 | 700,646 | +55,174 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 216,611 | 695,734 | +479,123 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 110,784 | 668,106 | +557,322 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 530,078 | 662,246 | +132,168 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 654,395 | +654,395 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 605,565 | +605,565 | 0.00 | 0.00 | +0.00 | buy |
| Swedbank AB | 0 | 550,000 | +550,000 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 314,846 | 433,713 | +118,867 | 0.03 | 0.06 | +0.03 | buy |
| Point72 Asset Management, L.P. | 526,162 | 419,800 | -106,362 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 708,463 | 372,449 | -336,014 | 0.11 | 0.11 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 79,713 | 372,025 | +292,312 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 269,487 | 273,356 | +3,869 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 260,100 | +260,100 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 155,860 | 237,221 | +81,361 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 320,273 | 236,835 | -83,438 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 253,828 | 176,516 | -77,312 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 120,891 | 171,266 | +50,375 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 282,764 | 158,016 | -124,748 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 170,176 | 157,567 | -12,609 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 123,790 | +123,790 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 119,989 | +119,989 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 137,090 | 118,790 | -18,300 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,000 | 110,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brooklyn Investment Group | 77,911 | 98,642 | +20,731 | 0.02 | 0.02 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 309,835 | 93,867 | -215,968 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 91,021 | +91,021 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 77,891 | 84,090 | +6,199 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 178,500 | 81,648 | -96,852 | 0.20 | 0.11 | -0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 55,667 | 67,420 | +11,753 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 68,508 | 63,835 | -4,673 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 199,315 | 61,815 | -137,500 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 123,358 | 60,637 | -62,721 | 0.01 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 75,633 | 60,306 | -15,327 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 85,000 | 60,000 | -25,000 | 0.19 | 0.17 | -0.02 | sell |
| Graham Capital Management, L.P. | 0 | 53,398 | +53,398 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,845 | 53,195 | -16,650 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 18,459 | 52,039 | +33,580 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 41,607 | 50,349 | +8,742 | 0.03 | 0.05 | +0.02 | buy |
| Sivia Capital Partners, LLC | 41,500 | 48,500 | +7,000 | 0.03 | 0.05 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 69,167 | 46,303 | -22,864 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 56,001 | 44,225 | -11,776 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 39,839 | 39,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jain Global LLC | 0 | 39,505 | +39,505 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 88,097 | 38,667 | -49,430 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,930 | 38,467 | -13,463 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 26,223 | 33,925 | +7,702 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 14,580 | 33,193 | +18,613 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 30,580 | +30,580 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 34,714 | 30,296 | -4,418 | 0.01 | 0.01 | +0.00 | sell |
| Farther Finance Advisors, LLC | 38,001 | 29,176 | -8,825 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,798 | +26,798 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 32,398 | 25,736 | -6,662 | 0.00 | 0.00 | +0.00 | sell |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 13,473 | 25,154 | +11,681 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 25,136 | +25,136 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,087 | +24,087 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 16,897 | +16,897 | 0.00 | 0.01 | +0.01 | buy |
| OPPENHEIMER & CO INC | 15,500 | 15,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 14,743 | +14,743 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 12,995 | 13,145 | +150 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 53,178 | 12,944 | -40,234 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 12,849 | +12,849 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 54,697 | 12,102 | -42,595 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 1,017 | 10,480 | +9,463 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 11,833 | 10,302 | -1,531 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 86,465 | 8,457 | -78,008 | 0.00 | 0.00 | -0.00 | sell |