| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,884,263 | 12,681,043 | +3,796,780 | 1.52 | 2.55 | +1.03 | buy |
| MORGAN STANLEY | 0 | 1,917,827 | +1,917,827 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 2,654,944 | 4,000,000 | +1,345,056 | 2.93 | 5.05 | +2.12 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 1,500,000 | +1,000,000 | 0.17 | 0.50 | +0.33 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 844,177 | +844,177 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 654,395 | +654,395 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 605,565 | +605,565 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 110,784 | 668,106 | +557,322 | 0.00 | 0.00 | +0.00 | buy |
| Swedbank AB | 0 | 550,000 | +550,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 216,611 | 695,734 | +479,123 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 8,325,375 | 8,775,375 | +450,000 | 1.34 | 1.93 | +0.59 | buy |
| D. E. Shaw & Co., Inc. | 79,713 | 372,025 | +292,312 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 260,100 | +260,100 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,115,379 | 1,309,236 | +193,857 | 3.17 | 4.60 | +1.44 | buy |
| GOLDMAN SACHS GROUP INC | 530,078 | 662,246 | +132,168 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 123,790 | +123,790 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 119,989 | +119,989 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 314,846 | 433,713 | +118,867 | 0.03 | 0.06 | +0.03 | buy |
| Walleye Capital LLC | 0 | 91,021 | +91,021 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 155,860 | 237,221 | +81,361 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 797,118 | 856,600 | +59,482 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 645,472 | 700,646 | +55,174 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 53,398 | +53,398 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 120,891 | 171,266 | +50,375 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,310,233 | 1,350,333 | +40,100 | 0.78 | 1.14 | +0.36 | buy |
| Jain Global LLC | 0 | 39,505 | +39,505 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 18,459 | 52,039 | +33,580 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 30,580 | +30,580 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 26,798 | +26,798 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 25,136 | +25,136 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 24,087 | +24,087 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 77,911 | 98,642 | +20,731 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 831,045 | 850,978 | +19,933 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 14,580 | 33,193 | +18,613 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 16,897 | +16,897 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 14,743 | +14,743 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,849 | +12,849 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 55,667 | 67,420 | +11,753 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,473 | 25,154 | +11,681 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,017 | 10,480 | +9,463 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 41,607 | 50,349 | +8,742 | 0.03 | 0.05 | +0.02 | buy |
| Police & Firemen's Retirement System of New Jersey | 26,223 | 33,925 | +7,702 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 41,500 | 48,500 | +7,000 | 0.03 | 0.05 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 77,891 | 84,090 | +6,199 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 269,487 | 273,356 | +3,869 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,995 | +1,995 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,651 | 7,202 | +1,551 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 1,524 | +1,524 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 672 | 2,105 | +1,433 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 639 | +639 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 617 | +617 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 363 | +363 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Management Group, LLC | 0 | 294 | +294 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,000 | 2,279 | +279 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 12,995 | 13,145 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 1 | 47 | +46 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,677 | 6,682 | +5 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 7,964,000 | 0 | 0.33 | 0.44 | +0.11 | hold |
| MAI Capital Management | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 553 | 553 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 726,851 | 726,851 | 0 | 0.67 | 0.66 | -0.01 | hold |
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 4.20 | 4.79 | +0.59 | hold |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 5.02 | 4.17 | -0.85 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 3.22 | 2.17 | -1.05 | hold |
| Frazier Life Sciences Management, L.P. | 11,462,301 | 11,462,301 | 0 | 1.05 | 1.23 | +0.18 | hold |
| Susquehanna Portfolio Strategies, LLC | 39,839 | 39,839 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,000 | 110,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OPPENHEIMER & CO INC | 15,500 | 15,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 3,982 | 3,982 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 9 | 4 | -5 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 306 | 277 | -29 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 318 | 0 | -318 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 4,395 | 3,667 | -728 | 0.00 | 0.00 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 11,833 | 10,302 | -1,531 | 0.00 | 0.00 | +0.00 | sell |
| Truvestments Capital LLC | 1,712 | 0 | -1,712 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,686 | 6,531 | -2,155 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 34,714 | 30,296 | -4,418 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 68,508 | 63,835 | -4,673 | 0.00 | 0.00 | +0.00 | sell |
| EMERALD ADVISERS, LLC | 3,534,368 | 3,529,324 | -5,044 | 0.30 | 0.40 | +0.11 | sell |
| ProShare Advisors LLC | 32,398 | 25,736 | -6,662 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 7,047 | 0 | -7,047 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 38,001 | 29,176 | -8,825 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 56,001 | 44,225 | -11,776 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 170,176 | 157,567 | -12,609 | 0.00 | 0.00 | +0.00 | sell |
| KLP KAPITALFORVALTNING AS | 13,200 | 0 | -13,200 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,930 | 38,467 | -13,463 | 0.00 | 0.00 | +0.00 | sell |
| May Hill Capital, LLC | 14,097 | 0 | -14,097 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 75,633 | 60,306 | -15,327 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,845 | 53,195 | -16,650 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 17,000 | 0 | -17,000 | 0.01 | 0.00 | -0.01 | sell |