| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 3,866,762 | 8,815,358 | +4,948,596 | 0.01 | 0.03 | +0.02 | buy |
| Sofinnova Investments, Inc. | 157,908 | 2,382,835 | +2,224,927 | 0.04 | 0.63 | +0.59 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 2,060,173 | +2,060,173 | 0.00 | 0.00 | +0.00 | buy |
| Altium Capital Management LLC | 0 | 1,333,000 | +1,333,000 | 0.00 | 4.32 | +4.32 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 1,042,902 | +1,042,902 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 379,936 | 972,945 | +593,009 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,537,314 | 1,768,053 | +230,739 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 221,510 | +221,510 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 1,913,349 | 2,088,323 | +174,974 | 0.79 | 0.80 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 103,900 | 256,900 | +153,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 19,585 | 169,940 | +150,355 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,764,601 | 5,914,947 | +150,346 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 135,842 | +135,842 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 125,749 | +125,749 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 16,028 | 123,956 | +107,928 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,221,488 | 2,326,873 | +105,385 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 32,526 | 136,700 | +104,174 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 0 | 90,919 | +90,919 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 88,926 | +88,926 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 60,458 | +60,458 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 54,471 | 106,236 | +51,765 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 746,990 | 794,909 | +47,919 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 226,229 | 268,447 | +42,218 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 88,305 | 127,200 | +38,895 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 261,435 | 295,701 | +34,266 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 70,511 | 102,990 | +32,479 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 28,876 | +28,876 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 25,782 | +25,782 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,187 | 38,225 | +25,038 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 61,585 | 86,343 | +24,758 | 0.00 | 0.00 | +0.00 | buy |
| ADVISORY RESEARCH INC | 0 | 21,129 | +21,129 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 20,600 | +20,600 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,548 | 19,507 | +16,959 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 15,701 | +15,701 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 15,654 | +15,654 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 48 | 15,318 | +15,270 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 21,842 | 36,215 | +14,373 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 37,142 | 49,862 | +12,720 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,786 | 33,165 | +12,379 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 12,314 | +12,314 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,736 | 23,601 | +11,865 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 121,534 | 130,064 | +8,530 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 40,543 | 48,616 | +8,073 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,112 | 30,098 | +7,986 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 4,500 | +4,500 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 19,000 | 22,510 | +3,510 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 2,996 | +2,996 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 27,320 | 29,067 | +1,747 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,951 | 18,014 | +1,063 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 553 | +553 | 0.00 | 0.00 | +0.00 | buy |
| Tyler-Stone Wealth Management | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,054 | 9,054 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 37,446 | 37,446 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 7.14 | 7.67 | +0.52 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,232,751 | 14,232,751 | 0 | 6.02 | 6.41 | +0.40 | hold |
| Truvestments Capital LLC | 2,713 | 2,713 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Gladstone Institutional Advisory LLC | 14,000 | 14,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 1,150,000 | 1,150,000 | 0 | 1.42 | 1.08 | -0.34 | hold |
| Cornerstone Planning Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TCG Crossover Management, LLC | 10,000,000 | 10,000,000 | 0 | 5.57 | 5.21 | -0.35 | hold |
| Frazier Life Sciences Management, L.P. | 4,000,000 | 4,000,000 | 0 | 1.01 | 1.01 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,341 | 5,341 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 7,509 | 7,509 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 248,562 | 248,562 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,915 | 35,915 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 44 | 30 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 2,032 | 2,000 | -32 | 0.00 | 0.00 | +0.00 | sell |
| Crewe Advisors LLC | 32 | 0 | -32 | 0.00 | 0.00 | -0.00 | sell |
| EARNEST PARTNERS LLC | 77 | 0 | -77 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 45,084 | 44,903 | -181 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 9,321 | 8,556 | -765 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 12,700 | 11,550 | -1,150 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 4,041 | 2,302 | -1,739 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 2,061 | 0 | -2,061 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,933 | 14,869 | -5,064 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 5,861 | 0 | -5,861 | 0.00 | 0.00 | -0.00 | sell |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 16,908 | 0 | -16,908 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 97,568 | 80,201 | -17,367 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 164,146 | 145,275 | -18,871 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 20,400 | 0 | -20,400 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 36,640 | 0 | -36,640 | 0.01 | 0.00 | -0.01 | sell |
| AXA S.A. | 1,789,948 | 1,747,673 | -42,275 | 0.02 | 0.03 | +0.00 | sell |
| Nantahala Capital Management, LLC | 1,039,364 | 987,903 | -51,461 | 0.50 | 0.46 | -0.03 | sell |
| AMERICAN CENTURY COMPANIES INC | 76,169 | 0 | -76,169 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 2,000,502 | 1,817,213 | -183,289 | 0.00 | 0.01 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 380,352 | 176,886 | -203,466 | 0.03 | 0.03 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,938,551 | 7,637,930 | -300,621 | 0.07 | 0.07 | +0.01 | sell |
| Sio Capital Management, LLC | 896,250 | 0 | -896,250 | 1.05 | 0.00 | -1.05 | sell |
| Polar Capital Holdings Plc | 1,000,000 | 0 | -1,000,000 | 0.03 | 0.00 | -0.03 | sell |
| FIRST MANHATTAN CO. LLC. | 1,063,137 | 0 | -1,063,137 | 0.01 | 0.00 | -0.01 | sell |
| CAXTON CORP | 3,313,602 | 353,441 | -2,960,161 | 47.59 | 8.97 | -38.62 | sell |
| VR Adviser, LLC | 7,184,865 | 3,500,000 | -3,684,865 | 2.86 | 1.13 | -1.73 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 10,908,086 | 6,255,406 | -4,652,680 | 0.23 | 0.18 | -0.05 | sell |