| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 3,866,762 | 8,815,358 | +4,948,596 | 0.01 | 0.03 | +0.02 | buy |
| Sofinnova Investments, Inc. | 157,908 | 2,382,835 | +2,224,927 | 0.04 | 0.63 | +0.59 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 380,352 | 176,886 | +203,466 | 0.04 | 0.06 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 2,000,502 | 1,817,213 | +183,289 | 0.01 | 0.01 | 0.00 | sell |
| Vivo Capital, LLC | 1,913,349 | 2,088,323 | +174,974 | 0.79 | 0.80 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 226,229 | 268,447 | +42,218 | 0.00 | 0.01 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,039,364 | 987,903 | -51,461 | 0.34 | 0.28 | -0.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,938,551 | 7,637,930 | -300,621 | 0.07 | 0.07 | +0.01 | sell |
| CAXTON CORP | 3,313,602 | 353,441 | -2,960,161 | 47.59 | 8.97 | -38.62 | sell |
| VR Adviser, LLC | 7,184,865 | 3,500,000 | -3,684,865 | 2.86 | 1.13 | -1.73 | sell |