| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 5.65 | 4.24 | -1.41 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,565,457 | 14,565,457 | 0 | 6.43 | 5.26 | -1.17 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 4.44 | 3.71 | -0.73 | hold |
| Vestal Point Capital, LP | 8,090,000 | 10,775,000 | +2,685,000 | 2.71 | 1.96 | -0.75 | buy |
| BlackRock, Inc. | 9,399,087 | 9,588,099 | +189,012 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 8,157,385 | 8,660,379 | +502,994 | 1.39 | 1.10 | -0.28 | buy |
| VANGUARD GROUP INC | 7,944,011 | 8,309,970 | +365,959 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,465,777 | 7,964,000 | +1,498,223 | 0.41 | 0.47 | +0.06 | buy |
| Nantahala Capital Management, LLC | 5,180,951 | 7,525,259 | +2,344,308 | 1.85 | 1.62 | -0.23 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,560,000 | 6,835,000 | +2,275,000 | 0.11 | 0.11 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,624,012 | 5,481,654 | -3,142,358 | 0.01 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 5,662,550 | 5,471,299 | -191,251 | 1.99 | 1.23 | -0.76 | sell |
| STATE STREET CORP | 4,138,276 | 4,174,079 | +35,803 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,726,850 | 2,784,037 | +57,187 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 2,305,195 | 2,686,938 | +381,743 | 0.08 | 0.06 | -0.03 | buy |
| Rosalind Advisors, Inc. | 0 | 2,654,944 | +2,654,944 | 0.00 | 4.39 | +4.39 | buy |
| EMERALD ADVISERS, LLC | 0 | 2,332,680 | +2,332,680 | 0.00 | 0.28 | +0.28 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,753,701 | 2,115,771 | -4,637,930 | 0.05 | 0.01 | -0.04 | sell |
| Altium Capital Management LLC | 1,575,000 | 1,579,000 | +4,000 | 1.99 | 1.51 | -0.48 | buy |
| JPMORGAN CHASE & CO | 69,490 | 1,423,139 | +1,353,649 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 1,375,888 | +1,375,888 | 0.00 | 0.26 | +0.26 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 563,107 | 1,211,533 | +648,426 | 0.39 | 0.69 | +0.30 | buy |
| NORTHERN TRUST CORP | 987,790 | 1,077,363 | +89,573 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,083,893 | 1,053,508 | -30,385 | 0.00 | 0.00 | -0.00 | sell |
| AXA S.A. | 1,051,432 | 1,049,775 | -1,657 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 742,634 | 988,468 | +245,834 | 0.53 | 0.63 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 911,617 | 963,821 | +52,204 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 874,541 | 927,595 | +53,054 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 690,609 | 837,467 | +146,858 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 657,849 | 785,477 | +127,628 | 0.01 | 0.01 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 700,987 | +700,987 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 699,698 | +699,698 | 0.00 | 1.62 | +1.62 | buy |
| GOLDMAN SACHS GROUP INC | 696,807 | 666,482 | -30,325 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 530,317 | +530,317 | 0.00 | 0.07 | +0.07 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 200,000 | 508,338 | +308,338 | 0.76 | 1.37 | +0.61 | buy |
| MILLENNIUM MANAGEMENT LLC | 280,664 | 482,263 | +201,599 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 700,000 | 410,586 | -289,414 | 0.46 | 0.20 | -0.26 | sell |
| MORGAN STANLEY | 471,355 | 395,958 | -75,397 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 289,915 | 390,715 | +100,800 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 361,229 | +361,229 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 283,242 | 254,253 | -28,989 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 235,760 | 253,630 | +17,870 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 231,005 | 236,705 | +5,700 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 115,831 | 228,536 | +112,705 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 214,625 | +214,625 | 0.00 | 0.06 | +0.06 | buy |
| Swiss National Bank | 190,800 | 178,000 | -12,800 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 316,189 | 173,396 | -142,793 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 86,330 | 159,461 | +73,131 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,815 | 156,983 | +31,168 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 168,125 | 146,997 | -21,128 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 138,211 | 143,661 | +5,450 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 132,384 | 141,425 | +9,041 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 128,501 | 138,771 | +10,270 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 170,079 | 134,924 | -35,155 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 123,968 | 132,968 | +9,000 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 44,095 | 122,635 | +78,540 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 40,963 | 103,288 | +62,325 | 0.10 | 0.13 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 53,895 | 103,099 | +49,204 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 100,770 | 100,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 25,693 | 99,959 | +74,266 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 95,577 | 95,577 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 94,567 | 86,465 | -8,102 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 83,451 | 82,715 | -736 | 0.00 | 0.00 | -0.00 | sell |
| F/m Investments LLC | 0 | 81,343 | +81,343 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,788 | 72,144 | +2,356 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 17,013 | 70,560 | +53,547 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 41,017 | 67,572 | +26,555 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 44,008 | 63,616 | +19,608 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 41,491 | 59,277 | +17,786 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 66,907 | 59,049 | -7,858 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 61,697 | 57,367 | -4,330 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 45,259 | 51,589 | +6,330 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 46,958 | 48,797 | +1,839 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,482 | 48,482 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 44,956 | 44,734 | -222 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,432 | 43,668 | +5,236 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 245,800 | 42,400 | -203,400 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 31,531 | 40,627 | +9,096 | 0.00 | 0.00 | -0.00 | buy |
| Sivia Capital Partners, LLC | 40,500 | 38,000 | -2,500 | 0.10 | 0.06 | -0.04 | sell |
| LMR Partners LLP | 36,800 | 36,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 31,658 | 36,390 | +4,732 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 34,215 | 29,575 | -4,640 | 0.01 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 24,743 | 27,118 | +2,375 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 28,406 | 26,236 | -2,170 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 25,782 | 25,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 22,701 | 21,222 | -1,479 | 0.05 | 0.03 | -0.02 | sell |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jump Financial, LLC | 0 | 20,755 | +20,755 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 15,864 | +15,864 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 15,627 | +15,627 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 115,604 | 15,600 | -100,004 | 0.01 | 0.00 | -0.01 | sell |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 12,179 | +12,179 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 12,139 | +12,139 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 140,010 | 11,246 | -128,764 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 11,136 | +11,136 | 0.00 | 0.00 | +0.00 | buy |