| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 8,090,000 | 10,775,000 | +2,685,000 | 2.71 | 1.96 | -0.75 | buy |
| Rosalind Advisors, Inc. | 0 | 2,654,944 | +2,654,944 | 0.00 | 4.39 | +4.39 | buy |
| Nantahala Capital Management, LLC | 5,180,951 | 7,525,259 | +2,344,308 | 1.85 | 1.62 | -0.23 | buy |
| EMERALD ADVISERS, LLC | 0 | 2,332,680 | +2,332,680 | 0.00 | 0.28 | +0.28 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,560,000 | 6,835,000 | +2,275,000 | 0.11 | 0.11 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,465,777 | 7,964,000 | +1,498,223 | 0.41 | 0.47 | +0.06 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 1,375,888 | +1,375,888 | 0.00 | 0.26 | +0.26 | buy |
| JPMORGAN CHASE & CO | 69,490 | 1,423,139 | +1,353,649 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 700,987 | +700,987 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 699,698 | +699,698 | 0.00 | 1.62 | +1.62 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 563,107 | 1,211,533 | +648,426 | 0.39 | 0.69 | +0.30 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 530,317 | +530,317 | 0.00 | 0.07 | +0.07 | buy |
| Frazier Life Sciences Management, L.P. | 8,157,385 | 8,660,379 | +502,994 | 1.39 | 1.10 | -0.28 | buy |
| Woodline Partners LP | 2,305,195 | 2,686,938 | +381,743 | 0.08 | 0.06 | -0.03 | buy |
| VANGUARD GROUP INC | 7,944,011 | 8,309,970 | +365,959 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 361,229 | +361,229 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 200,000 | 508,338 | +308,338 | 0.76 | 1.37 | +0.61 | buy |
| ADAR1 Capital Management, LLC | 742,634 | 988,468 | +245,834 | 0.53 | 0.63 | +0.10 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 214,625 | +214,625 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 280,664 | 482,263 | +201,599 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 9,399,087 | 9,588,099 | +189,012 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 690,609 | 837,467 | +146,858 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 657,849 | 785,477 | +127,628 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 115,831 | 228,536 | +112,705 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 289,915 | 390,715 | +100,800 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 987,790 | 1,077,363 | +89,573 | 0.00 | 0.00 | -0.00 | buy |
| F/m Investments LLC | 0 | 81,343 | +81,343 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 44,095 | 122,635 | +78,540 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 25,693 | 99,959 | +74,266 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 86,330 | 159,461 | +73,131 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 40,963 | 103,288 | +62,325 | 0.10 | 0.13 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,726,850 | 2,784,037 | +57,187 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 17,013 | 70,560 | +53,547 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 874,541 | 927,595 | +53,054 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 911,617 | 963,821 | +52,204 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 53,895 | 103,099 | +49,204 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 4,138,276 | 4,174,079 | +35,803 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,815 | 156,983 | +31,168 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 41,017 | 67,572 | +26,555 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 20,755 | +20,755 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 44,008 | 63,616 | +19,608 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 235,760 | 253,630 | +17,870 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 41,491 | 59,277 | +17,786 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 15,864 | +15,864 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 15,627 | +15,627 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 12,179 | +12,179 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 12,139 | +12,139 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,136 | +11,136 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 10,798 | +10,798 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 128,501 | 138,771 | +10,270 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,482 | 48,482 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 31,531 | 40,627 | +9,096 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 132,384 | 141,425 | +9,041 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 123,968 | 132,968 | +9,000 | 0.01 | 0.01 | -0.00 | buy |
| SG Americas Securities, LLC | 45,259 | 51,589 | +6,330 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 231,005 | 236,705 | +5,700 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 138,211 | 143,661 | +5,450 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,432 | 43,668 | +5,236 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 31,658 | 36,390 | +4,732 | 0.01 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 1,575,000 | 1,579,000 | +4,000 | 1.99 | 1.51 | -0.48 | buy |
| Sio Capital Management, LLC | 0 | 3,747 | +3,747 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,281 | 6,046 | +2,765 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 24,743 | 27,118 | +2,375 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,788 | 72,144 | +2,356 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 46,958 | 48,797 | +1,839 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,026 | +1,026 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 141 | 859 | +718 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 302 | +302 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 60 | 350 | +290 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 7,047 | 7,047 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 11,689 | 11,689 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 100,770 | 100,770 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN ADVISORY INC | 20,854 | 20,854 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 553 | 553 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 5.65 | 4.24 | -1.41 | hold |
| Allworth Financial LP | 2,046 | 2,046 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 36,800 | 36,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Kovitz Investment Group Partners, LLC | 25,214 | 25,214 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHOREO, LLC | 14,658 | 14,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 14,565,457 | 14,565,457 | 0 | 6.43 | 5.26 | -1.17 | hold |
| Truvestments Capital LLC | 1,712 | 1,712 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cornerstone Planning Group LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 4.44 | 3.71 | -0.73 | hold |
| Farther Finance Advisors, LLC | 25,782 | 25,782 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 114 | 114 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 95,577 | 95,577 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 13,855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 3,087 | 3,087 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 13 | 13 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,780 | 25,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 55 | 44 | -11 | 0.00 | 0.00 | 0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 155 | 0 | -155 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 193 | 0 | -193 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 44,956 | 44,734 | -222 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 5,953 | 5,719 | -234 | 0.00 | 0.00 | -0.00 | sell |