| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 8,090,000 | 10,775,000 | +2,685,000 | 2.71 | 1.96 | -0.75 | buy |
| Nantahala Capital Management, LLC | 5,180,951 | 7,525,259 | +2,344,308 | 1.11 | 0.99 | -0.12 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,465,777 | 7,964,000 | +1,498,223 | 0.41 | 0.46 | +0.05 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 563,107 | 1,211,533 | +648,426 | 0.38 | 0.67 | +0.29 | buy |
| Frazier Life Sciences Management, L.P. | 8,157,385 | 8,660,379 | +502,994 | 1.39 | 1.10 | -0.28 | buy |
| Woodline Partners LP | 2,305,195 | 2,686,938 | +381,743 | 0.08 | 0.06 | -0.03 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 200,000 | 508,338 | +308,338 | 0.76 | 1.37 | +0.61 | buy |
| ADAR1 Capital Management, LLC | 742,634 | 988,468 | +245,834 | 0.53 | 0.63 | +0.10 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 690,609 | 837,467 | +146,858 | 0.01 | 0.01 | -0.00 | buy |
| EntryPoint Capital, LLC | 40,963 | 103,288 | +62,325 | 0.10 | 0.13 | +0.03 | buy |
| ALPS ADVISORS INC | 128,501 | 138,771 | +10,270 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 38,482 | 48,482 | +10,000 | 0.01 | 0.01 | 0.00 | buy |
| ALGERT GLOBAL LLC | 123,968 | 132,968 | +9,000 | 0.01 | 0.01 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 31,658 | 36,390 | +4,732 | 0.01 | 0.01 | -0.00 | buy |
| Altium Capital Management LLC | 1,575,000 | 1,579,000 | +4,000 | 1.99 | 1.51 | -0.48 | buy |
| E Fund Management Co., Ltd. | 10,802 | 10,399 | -403 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 22,701 | 21,222 | -1,479 | 0.05 | 0.03 | -0.02 | sell |
| Sivia Capital Partners, LLC | 40,500 | 38,000 | -2,500 | 0.10 | 0.06 | -0.04 | sell |
| Rafferty Asset Management, LLC | 168,125 | 146,997 | -21,128 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 5,662,550 | 5,471,299 | -191,251 | 1.91 | 1.22 | -0.68 | sell |
| Affinity Asset Advisors, LLC | 700,000 | 410,586 | -289,414 | 0.46 | 0.20 | -0.26 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,753,701 | 2,115,771 | -4,637,930 | 0.05 | 0.01 | -0.04 | sell |