| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 13,569,000 | +5,605,000 | 0.43 | 1.04 | +0.61 | buy |
| Affinity Asset Advisors, LLC | 1,500,000 | 2,797,153 | +1,297,153 | 0.50 | 1.21 | +0.71 | buy |
| VR Adviser, LLC | 12,681,043 | 13,740,375 | +1,059,332 | 2.55 | 4.09 | +1.54 | buy |
| Swedbank AB | 550,000 | 850,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 433,713 | 678,813 | +245,100 | 0.06 | 0.16 | +0.10 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,151,358 | 2,396,458 | +245,100 | 0.40 | 0.70 | +0.31 | buy |
| GSA CAPITAL PARTNERS LLP | 372,449 | 140,753 | +231,696 | 0.13 | 0.08 | 0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 39,839 | 59,469 | +19,630 | 0.00 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 30,296 | 33,155 | +2,859 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,667 | 3,998 | +331 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 48,500 | 48,507 | +7 | 0.05 | 0.06 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 50,349 | 38,443 | -11,906 | 0.05 | 0.06 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 3,529,324 | 3,495,496 | -33,828 | 0.40 | 0.65 | +0.25 | sell |
| EntryPoint Capital, LLC | 81,648 | 40,716 | -40,932 | 0.11 | 0.10 | -0.02 | sell |
| Sio Capital Management, LLC | 726,851 | 613,888 | -112,963 | 0.66 | 0.58 | -0.07 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,350,333 | 1,178,164 | -172,169 | 1.02 | 1.37 | +0.36 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,309,236 | 995,353 | -313,883 | 4.60 | 3.21 | -1.39 | sell |
| ADAR1 Capital Management, LLC | 1,988,288 | 1,405,452 | -582,836 | 0.70 | 0.63 | -0.07 | sell |
| Rosalind Advisors, Inc. | 4,000,000 | 3,403,721 | -596,279 | 4.88 | 7.21 | +2.33 | sell |
| Nantahala Capital Management, LLC | 8,775,375 | 7,344,783 | -1,430,592 | 1.09 | 1.46 | +0.38 | sell |
| Frazier Life Sciences Management, L.P. | 11,462,301 | 9,862,301 | -1,600,000 | 1.23 | 1.60 | +0.37 | sell |
| Sofinnova Investments, Inc. | 2,427,724 | 304,770 | -2,122,954 | 0.47 | 0.08 | -0.39 | sell |
| Vestal Point Capital, LP | 4,015,000 | 1,606,000 | -2,409,000 | 0.65 | 0.36 | -0.30 | sell |