| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 24,471,264 | 24,471,264 | 0 | 4.79 | 7.52 | +2.73 | hold |
| Bain Capital Life Sciences Investors, LLC | 17,600,621 | 17,600,621 | 0 | 4.17 | 8.13 | +3.96 | hold |
| VR Adviser, LLC | 12,681,043 | 13,740,375 | +1,059,332 | 2.55 | 4.09 | +1.54 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,964,000 | 13,569,000 | +5,605,000 | 0.44 | 1.05 | +0.61 | buy |
| TCG Crossover Management, LLC | 12,362,205 | 12,362,205 | 0 | 2.17 | 2.47 | +0.30 | hold |
| BlackRock, Inc. | 8,448,240 | 11,097,289 | +2,649,049 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 8,313,194 | 10,041,647 | +1,728,453 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 11,462,301 | 9,862,301 | -1,600,000 | 1.23 | 1.60 | +0.37 | sell |
| Polar Capital Holdings Plc | 0 | 8,306,196 | +8,306,196 | 0.00 | 0.23 | +0.23 | buy |
| Nantahala Capital Management, LLC | 8,775,375 | 7,344,783 | -1,430,592 | 1.93 | 2.64 | +0.71 | sell |
| RTW INVESTMENTS, LP | 0 | 5,952,380 | +5,952,380 | 0.00 | 0.36 | +0.36 | buy |
| MARSHALL WACE, LLP | 0 | 4,559,921 | +4,559,921 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 2,359,858 | 4,333,022 | +1,973,164 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 237,221 | 4,244,640 | +4,007,419 | 0.00 | 0.10 | +0.10 | buy |
| EMERALD ADVISERS, LLC | 3,529,324 | 3,495,496 | -33,828 | 0.40 | 0.65 | +0.25 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,795,661 | 3,417,769 | +622,108 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 4,000,000 | 3,403,721 | -596,279 | 5.05 | 7.48 | +2.43 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 2,797,153 | +1,297,153 | 0.50 | 1.21 | +0.71 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,644,000 | 2,674,931 | +30,931 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 2,400,000 | +2,400,000 | 0.00 | 0.27 | +0.27 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 2,151,358 | 2,396,458 | +245,100 | 0.40 | 0.70 | +0.31 | buy |
| MORGAN STANLEY | 1,917,827 | 2,337,896 | +420,069 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 1,688,500 | +1,688,500 | 0.00 | 0.81 | +0.81 | buy |
| D. E. Shaw & Co., Inc. | 372,025 | 1,669,370 | +1,297,345 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 4,015,000 | 1,606,000 | -2,409,000 | 0.65 | 0.36 | -0.30 | sell |
| ADAR1 Capital Management, LLC | 1,988,288 | 1,405,452 | -582,836 | 0.70 | 0.63 | -0.07 | sell |
| Longaeva Partners L.P. | 0 | 1,246,042 | +1,246,042 | 0.00 | 0.89 | +0.89 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 1,350,333 | 1,178,164 | -172,169 | 1.14 | 1.48 | +0.34 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 963,798 | 1,161,672 | +197,874 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 946,732 | 1,077,625 | +130,893 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,061,198 | +1,061,198 | 0.00 | 0.01 | +0.01 | buy |
| Siren, L.L.C. | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.18 | +0.18 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 1,309,236 | 995,353 | -313,883 | 4.60 | 3.21 | -1.39 | sell |
| Swedbank AB | 550,000 | 850,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 850,978 | 824,717 | -26,261 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 668,106 | 774,492 | +106,386 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 856,600 | 751,255 | -105,345 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 171,266 | 688,595 | +517,329 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 433,713 | 678,813 | +245,100 | 0.06 | 0.16 | +0.10 | buy |
| Sio Capital Management, LLC | 726,851 | 613,888 | -112,963 | 0.66 | 0.61 | -0.04 | sell |
| JANE STREET GROUP, LLC | 605,565 | 584,289 | -21,276 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 543,756 | +543,756 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 844,177 | 534,968 | -309,209 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 662,246 | 516,598 | -145,648 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 119,989 | 423,596 | +303,607 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 373,034 | +373,034 | 0.00 | 0.07 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 260,100 | 332,100 | +72,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 273,356 | 312,870 | +39,514 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 176,516 | 306,940 | +130,424 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 2,427,724 | 304,770 | -2,122,954 | 0.53 | 0.08 | -0.45 | sell |
| Nuveen, LLC | 236,835 | 272,602 | +35,767 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 695,734 | 202,883 | -492,851 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 188,214 | +188,214 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 170,195 | +170,195 | 0.00 | 0.06 | +0.06 | buy |
| DIMENSIONAL FUND ADVISORS LP | 700,646 | 170,129 | -530,517 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 84,090 | 167,644 | +83,554 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 157,567 | 152,775 | -4,792 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 91,021 | 150,084 | +59,063 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 372,449 | 140,753 | -231,696 | 0.11 | 0.07 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 118,790 | 127,040 | +8,250 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 110,000 | 90,000 | -20,000 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 89,858 | +89,858 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 86,160 | +86,160 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 83,334 | +83,334 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 83,089 | +83,089 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 60,306 | 78,551 | +18,245 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 93,867 | 74,882 | -18,985 | 0.00 | 0.00 | +0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 74,115 | +74,115 | 0.00 | 0.16 | +0.16 | buy |
| JPMORGAN CHASE & CO | 63,835 | 73,059 | +9,224 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,195 | 71,014 | +17,819 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 70,695 | +70,695 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 67,420 | 69,536 | +2,116 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 65,615 | +65,615 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 60,637 | 60,637 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 39,839 | 59,469 | +19,630 | 0.00 | 0.01 | +0.00 | buy |
| Graham Capital Management, L.P. | 53,398 | 56,013 | +2,615 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 44,225 | 55,719 | +11,494 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 51,700 | +51,700 | 0.00 | 0.00 | +0.00 | buy |
| Sivia Capital Partners, LLC | 48,500 | 48,507 | +7 | 0.05 | 0.06 | +0.01 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 46,000 | +46,000 | 0.00 | 0.06 | +0.06 | buy |
| SG Americas Securities, LLC | 0 | 45,526 | +45,526 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,467 | 43,547 | +5,080 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 33,193 | 41,652 | +8,459 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 46,303 | 40,958 | -5,345 | 0.00 | 0.00 | +0.00 | sell |
| EntryPoint Capital, LLC | 81,648 | 40,716 | -40,932 | 0.11 | 0.10 | -0.02 | sell |
| Caitong International Asset Management Co., Ltd | 1,995 | 39,649 | +37,654 | 0.00 | 0.06 | +0.05 | buy |
| Virtus Investment Advisers, LLC | 50,349 | 38,443 | -11,906 | 0.05 | 0.06 | +0.01 | sell |
| Jain Global LLC | 39,505 | 37,705 | -1,800 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 98,642 | 36,809 | -61,833 | 0.02 | 0.01 | -0.01 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,855 | 36,555 | +22,700 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 35,145 | +35,145 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 25,736 | 34,869 | +9,133 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 33,925 | 33,925 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 30,296 | 33,155 | +2,859 | 0.01 | 0.02 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 30,580 | 32,678 | +2,098 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 25,154 | 31,204 | +6,050 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,202 | 27,849 | +20,647 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 29,176 | 26,896 | -2,280 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 0 | 26,500 | +26,500 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 25,214 | +25,214 | 0.00 | 0.00 | +0.00 | buy |