| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 1,200,000 | 61,907,605 | +60,707,605 | 0.26 | 12.48 | +12.22 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 58,651,170 | +58,651,170 | 0.00 | 0.59 | +0.59 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,477,917 | 14,373,199 | +12,895,282 | 0.00 | 0.03 | +0.03 | buy |
| ARK Investment Management LLC | 0 | 13,042,440 | +13,042,440 | 0.00 | 0.24 | +0.24 | buy |
| VANGUARD GROUP INC | 4,133,939 | 13,034,043 | +8,900,104 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 8,853,491 | +8,853,491 | 0.00 | 0.02 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 8,853,491 | +8,853,491 | 0.00 | 0.24 | +0.24 | buy |
| MORGAN STANLEY | 3,928,646 | 7,617,876 | +3,689,230 | 0.00 | 0.00 | +0.00 | buy |
| Indaba Capital Management, L.P. | 7,446,229 | 7,363,064 | -83,165 | 9.45 | 13.03 | +3.58 | sell |
| Tikvah Management LLC | 0 | 6,551,058 | +6,551,058 | 0.00 | 5.56 | +5.56 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,182,187 | 4,845,051 | +2,662,864 | 0.01 | 0.03 | +0.02 | buy |
| Neuberger Berman Group LLC | 4,365,813 | 4,744,923 | +379,110 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 163,392 | 3,953,820 | +3,790,428 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 133,560 | 3,277,713 | +3,144,153 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,053,943 | 3,021,843 | -32,100 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 806,042 | 2,706,926 | +1,900,884 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 177,246 | 2,095,091 | +1,917,845 | 0.00 | 0.01 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 0 | 1,883,179 | +1,883,179 | 0.00 | 4.73 | +4.73 | buy |
| Qube Research & Technologies Ltd | 0 | 1,716,967 | +1,716,967 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 603,620 | 1,670,401 | +1,066,781 | 0.19 | 0.56 | +0.37 | buy |
| Slate Path Capital LP | 0 | 1,615,000 | +1,615,000 | 0.00 | 0.09 | +0.09 | buy |
| Magnetar Financial LLC | 0 | 1,515,390 | +1,515,390 | 0.00 | 0.09 | +0.09 | buy |
| JANE STREET GROUP, LLC | 315,949 | 1,383,697 | +1,067,748 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 298,637 | 1,341,357 | +1,042,720 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 1,266,859 | +1,266,859 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,039,600 | 1,253,858 | +214,258 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 191,284 | 1,229,288 | +1,038,004 | 0.00 | 0.03 | +0.02 | buy |
| NEEDHAM INVESTMENT MANAGEMENT LLC | 1,124,435 | 1,124,435 | 0 | 0.31 | 0.28 | -0.03 | hold |
| GAGNON SECURITIES LLC | 0 | 855,145 | +855,145 | 0.00 | 0.55 | +0.55 | buy |
| NORTHERN TRUST CORP | 201,098 | 784,928 | +583,830 | 0.00 | 0.00 | +0.00 | buy |
| METEORA CAPITAL, LLC | 0 | 677,100 | +677,100 | 0.00 | 0.31 | +0.31 | buy |
| CITIGROUP INC | 323,572 | 676,176 | +352,604 | 0.00 | 0.00 | +0.00 | buy |
| Gagnon Advisors, LLC | 0 | 672,294 | +672,294 | 0.00 | 1.58 | +1.58 | buy |
| TWO SIGMA INVESTMENTS, LP | 156,603 | 646,940 | +490,337 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 636,339 | +636,339 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 144,376 | 592,646 | +448,270 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 65,502 | 578,439 | +512,937 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 507,417 | +507,417 | 0.00 | 0.01 | +0.01 | buy |
| Zweig-DiMenna Associates LLC | 0 | 505,535 | +505,535 | 0.00 | 0.12 | +0.12 | buy |
| UBS Group AG | 0 | 483,944 | +483,944 | 0.00 | 0.00 | +0.00 | buy |
| Bradley & Co. Private Wealth Management, LLC | 50,000 | 447,877 | +397,877 | 0.10 | 0.98 | +0.88 | buy |
| RBF Capital, LLC | 0 | 441,572 | +441,572 | 0.00 | 0.07 | +0.07 | buy |
| Cubist Systematic Strategies, LLC | 27,310 | 441,232 | +413,922 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 428,660 | +428,660 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 426,200 | +426,200 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 62,768 | 423,518 | +360,750 | 0.04 | 0.30 | +0.26 | buy |
| Redmile Group, LLC | 0 | 411,631 | +411,631 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 807,858 | 331,662 | -476,196 | 0.06 | 0.02 | -0.04 | sell |
| JOHNSON & JOHNSON | 0 | 311,967 | +311,967 | 0.00 | 0.02 | +0.02 | buy |
| Man Group plc | 198,180 | 310,604 | +112,424 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 72,025 | 304,495 | +232,470 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 303,213 | +303,213 | 0.00 | 0.21 | +0.21 | buy |
| Laurion Capital Management LP | 300,010 | 300,010 | 0 | 0.02 | 0.02 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 236,479 | +236,479 | 0.00 | 0.01 | +0.01 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 215,520 | +215,520 | 0.00 | 0.04 | +0.04 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 212,000 | 212,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Jump Financial, LLC | 70,480 | 211,893 | +141,413 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 195,125 | +195,125 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 192,767 | +192,767 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 130,643 | 159,666 | +29,023 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 42,914 | 156,191 | +113,277 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 142,300 | +142,300 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 36,381 | 132,778 | +96,397 | 0.00 | 0.00 | +0.00 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 125,000 | 125,000 | 0 | 0.04 | 0.05 | +0.00 | hold |
| Jefferies Financial Group Inc. | 56,400 | 119,400 | +63,000 | 0.00 | 0.01 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 116,905 | +116,905 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 31,192 | 111,584 | +80,392 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 39,508 | 110,882 | +71,374 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 104,060 | +104,060 | 0.00 | 0.00 | +0.00 | buy |
| LUMINUS MANAGEMENT LLC | 0 | 95,000 | +95,000 | 0.00 | 0.12 | +0.12 | buy |
| FourWorld Capital Management LLC | 0 | 91,700 | +91,700 | 0.00 | 0.22 | +0.22 | buy |
| Bank of New York Mellon Corp | 110,121 | 87,600 | -22,521 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 23,472 | 81,617 | +58,145 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 78,090 | +78,090 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 192,670 | 76,101 | -116,569 | 0.00 | 0.00 | -0.00 | sell |
| Schoolcraft Capital LLC | 0 | 74,224 | +74,224 | 0.00 | 0.05 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 72,061 | +72,061 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 71,288 | 69,250 | -2,038 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,800 | 68,869 | +42,069 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 63,420 | +63,420 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 59,663 | +59,663 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 52,139 | 58,380 | +6,241 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 57,600 | +57,600 | 0.00 | 0.10 | +0.10 | buy |
| Polar Capital Holdings Plc | 56,585 | 56,585 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 0 | 49,001 | +49,001 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 14,367 | 45,383 | +31,016 | 0.00 | 0.00 | +0.00 | buy |
| Corvex Management LP | 0 | 44,400 | +44,400 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 42,591 | +42,591 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 37,400 | +37,400 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,927 | 36,900 | +25,973 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 30,800 | 30,282 | -518 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,317 | 26,803 | +17,486 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 26,383 | +26,383 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 26,094 | +26,094 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,130 | 26,018 | -112 | 0.01 | 0.01 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 27,800 | 23,800 | -4,000 | 0.01 | 0.00 | -0.00 | sell |
| Mariner, LLC | 0 | 23,628 | +23,628 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 23,444 | 23,300 | -144 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 11,985 | 23,264 | +11,279 | 0.00 | 0.00 | +0.00 | buy |