| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 7,617,876 | 12,934,541 | +5,316,665 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,706,926 | 6,794,869 | +4,087,943 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,341,357 | 4,337,152 | +2,995,795 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 13,034,043 | 16,003,158 | +2,969,115 | 0.00 | 0.00 | -0.00 | buy |
| Casdin Capital, LLC | 61,907,605 | 63,959,677 | +2,052,072 | 12.48 | 8.64 | -3.84 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 8,853,491 | 10,642,271 | +1,788,780 | 0.02 | 0.01 | -0.00 | buy |
| Nikko Asset Management Americas, Inc. | 8,853,491 | 10,642,271 | +1,788,780 | 0.24 | 0.22 | -0.02 | buy |
| Invenomic Capital Management LP | 0 | 950,114 | +950,114 | 0.00 | 0.09 | +0.09 | buy |
| CITADEL ADVISORS LLC | 0 | 905,346 | +905,346 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 87,600 | 980,983 | +893,383 | 0.00 | 0.00 | +0.00 | buy |
| Pacific Capital Partners Ltd | 0 | 750,000 | +750,000 | 0.00 | 0.88 | +0.88 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,584 | 847,355 | +735,771 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 561,521 | +561,521 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 10,748 | 407,467 | +396,719 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 315,690 | +315,690 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 304,231 | +304,231 | 0.00 | 0.01 | +0.01 | buy |
| Alpine Global Management, LLC | 0 | 293,706 | +293,706 | 0.00 | 0.09 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 104,060 | 382,488 | +278,428 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 784,928 | 1,002,377 | +217,449 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 63,420 | 243,237 | +179,817 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 132,778 | 305,516 | +172,738 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 23,264 | 161,911 | +138,647 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 133,531 | +133,531 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 122,200 | +122,200 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,199 | 125,792 | +121,593 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,760 | 136,237 | +118,477 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 117,395 | +117,395 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 107,619 | +107,619 | 0.00 | 0.05 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 103,036 | +103,036 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 68,869 | 165,043 | +96,174 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 76,915 | +76,915 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 26,383 | 97,307 | +70,924 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 428,660 | 488,860 | +60,200 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 72,061 | 131,610 | +59,549 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 192,767 | 247,203 | +54,436 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 195,125 | 246,336 | +51,211 | 0.00 | 0.00 | -0.00 | buy |
| GAGNON SECURITIES LLC | 855,145 | 898,509 | +43,364 | 0.55 | 0.36 | -0.19 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 41,903 | +41,903 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 34,374 | +34,374 | 0.00 | 0.03 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,690 | 50,330 | +32,640 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 32,097 | +32,097 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 29,558 | +29,558 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 25,117 | +25,117 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 24,201 | +24,201 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 22,856 | +22,856 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 26,094 | 48,287 | +22,193 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0 | 21,972 | +21,972 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 19,143 | +19,143 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 14,497 | +14,497 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 14,455 | +14,455 | 0.00 | 0.00 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 12,049 | +12,049 | 0.00 | 0.02 | +0.02 | buy |
| HighTower Advisors, LLC | 76,101 | 88,101 | +12,000 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,033 | +11,033 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 16,224 | 27,230 | +11,006 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 10,858 | +10,858 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 10,438 | +10,438 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 36,900 | 46,967 | +10,067 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 10,025 | +10,025 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,018 | 35,965 | +9,947 | 0.01 | 0.01 | -0.00 | buy |
| Arizona State Retirement System | 59,663 | 69,596 | +9,933 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 16,478 | 20,837 | +4,359 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,019 | +4,019 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 159,666 | 160,556 | +890 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 1,398 | 2,218 | +820 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 9,302 | 9,727 | +425 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 30,282 | 30,654 | +372 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Advisors, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 1 | 76 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 21,480 | 21,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 58,651,170 | 58,651,170 | 0 | 0.59 | 0.40 | -0.19 | hold |
| CIBC Private Wealth Group LLC | 900 | 900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 81,617 | 81,617 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TAKEDA PHARMACEUTICAL CO LTD | 16,515 | 16,515 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Redmile Group, LLC | 411,631 | 411,631 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Freestone Capital Holdings, LLC | 11,388 | 11,388 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corvex Management LP | 44,400 | 44,400 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 845 | 845 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Slate Path Capital LP | 1,615,000 | 1,615,000 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Gagnon Advisors, LLC | 672,294 | 672,294 | 0 | 1.58 | 0.91 | -0.67 | hold |
| Tikvah Management LLC | 6,551,058 | 6,551,058 | 0 | 5.56 | 3.78 | -1.78 | hold |
| Russell Investments Group, Ltd. | 220 | 220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 23,800 | 23,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 880 | 880 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Evolution Wealth Advisors, LLC | 12,210 | 12,210 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 1,883,179 | 1,883,179 | 0 | 4.73 | 3.56 | -1.17 | hold |
| Polar Capital Holdings Plc | 56,585 | 56,585 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eagle Bay Advisors LLC | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 32 | 32 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pictet Asset Management Holding SA | 11,366 | 11,366 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schoolcraft Capital LLC | 74,224 | 74,224 | 0 | 0.05 | 0.03 | -0.02 | hold |
| JOHNSON & JOHNSON | 311,967 | 311,967 | 0 | 0.02 | 0.14 | +0.12 | hold |
| Federation des caisses Desjardins du Quebec | 2,442 | 2,442 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 156,191 | 156,191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 42,591 | 42,591 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 49,001 | 49,001 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 236,479 | 236,479 | 0 | 0.01 | 0.00 | -0.00 | hold |