| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 63,959,677 | 71,254,677 | +7,295,000 | 8.64 | 9.17 | +0.52 | buy |
| VIKING GLOBAL INVESTORS LP | 58,651,170 | 58,651,170 | 0 | 0.40 | 0.41 | +0.01 | hold |
| VANGUARD GROUP INC | 16,003,158 | 17,292,092 | +1,288,934 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 12,934,541 | 15,245,461 | +2,310,920 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 10,642,271 | 9,578,563 | -1,063,708 | 0.01 | 0.01 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 10,642,271 | 9,572,492 | -1,069,779 | 0.22 | 0.21 | -0.01 | sell |
| ARK Investment Management LLC | 12,679,391 | 8,949,765 | -3,729,626 | 0.20 | 0.16 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 6,221,993 | 6,984,232 | +762,239 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 6,794,869 | 6,949,717 | +154,848 | 0.00 | 0.00 | +0.00 | buy |
| Tikvah Management LLC | 6,551,058 | 6,551,058 | 0 | 3.78 | 3.92 | +0.14 | hold |
| Hollow Brook Wealth Management LLC | 0 | 5,532,951 | +5,532,951 | 0.00 | 3.17 | +3.17 | buy |
| STATE STREET CORP | 4,337,152 | 5,495,136 | +1,157,984 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 4,137,246 | 4,729,846 | +592,600 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 2,851,165 | 3,228,360 | +377,195 | 0.00 | 0.00 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 3,008,643 | 2,962,123 | -46,520 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 1,002,377 | 2,631,638 | +1,629,261 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 847,355 | 2,445,083 | +1,597,728 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 1,883,179 | 1,883,179 | 0 | 3.56 | 3.13 | -0.42 | hold |
| Slate Path Capital LP | 1,615,000 | 1,615,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 998,162 | 991,704 | -6,458 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 640,983 | 918,542 | +277,559 | 0.00 | 0.00 | +0.00 | buy |
| Pacific Capital Partners Ltd | 750,000 | 825,000 | +75,000 | 0.88 | 0.93 | +0.05 | buy |
| NEEDHAM INVESTMENT MANAGEMENT LLC | 984,435 | 784,435 | -200,000 | 0.14 | 0.12 | -0.03 | sell |
| Bank of New York Mellon Corp | 980,983 | 755,468 | -225,515 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 304,231 | 614,552 | +310,321 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 488,860 | 469,960 | -18,900 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 419,702 | 419,702 | 0 | 0.20 | 0.21 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 0 | 407,755 | +407,755 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 407,467 | 381,489 | -25,978 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 362,385 | 332,381 | -30,004 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 315,690 | 315,690 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 403,529 | 314,241 | -89,288 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 311,967 | 311,967 | 0 | 0.14 | 0.14 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 382,488 | 306,871 | -75,617 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 175,536 | 253,305 | +77,769 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 247,203 | 246,951 | -252 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 236,479 | 236,479 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 305,516 | 236,396 | -69,120 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 246,336 | 231,551 | -14,785 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 75,934 | 230,625 | +154,691 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,004,558 | 201,000 | -803,558 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 257,680 | 185,246 | -72,434 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 97,307 | 183,290 | +85,983 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 242,154 | 181,814 | -60,340 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 125,792 | 168,460 | +42,668 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 156,191 | 164,993 | +8,802 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 165,043 | 164,993 | -50 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 161,911 | 162,847 | +936 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 160,556 | 161,556 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 161,473 | +161,473 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 162,312 | 157,724 | -4,588 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 76,915 | 143,325 | +66,410 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 133,531 | 140,362 | +6,831 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 139,748 | +139,748 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,229,132 | 138,140 | -1,090,992 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 131,610 | 131,610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 117,395 | 114,239 | -3,156 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 34,374 | 113,867 | +79,493 | 0.03 | 0.13 | +0.10 | buy |
| SG Americas Securities, LLC | 48,287 | 101,257 | +52,970 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 100,309 | +100,309 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 103,036 | 98,070 | -4,966 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 136,237 | 95,006 | -41,231 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 243,237 | 87,174 | -156,063 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 35,965 | 83,817 | +47,852 | 0.01 | 0.01 | +0.01 | buy |
| WEXFORD CAPITAL LP | 107,619 | 83,638 | -23,981 | 0.05 | 0.04 | -0.01 | sell |
| HSBC HOLDINGS PLC | 49,001 | 82,610 | +33,609 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 88,101 | 82,101 | -6,000 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,991 | 79,695 | -143,296 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 122,200 | 79,000 | -43,200 | 0.00 | 0.00 | -0.00 | sell |
| Schoolcraft Capital LLC | 74,224 | 74,224 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Arizona State Retirement System | 69,596 | 69,330 | -266 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 905,346 | 65,670 | -839,676 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 30,654 | 63,497 | +32,843 | 0.00 | 0.00 | +0.00 | buy |
| GAGNON SECURITIES LLC | 898,509 | 60,424 | -838,085 | 0.36 | 0.02 | -0.34 | sell |
| MARSHALL WACE, LLP | 81,617 | 58,145 | -23,472 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 0 | 55,740 | +55,740 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 52,225 | +52,225 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 50,330 | 50,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 46,967 | 45,881 | -1,086 | 0.00 | 0.00 | +0.00 | sell |
| Corvex Management LP | 44,400 | 44,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 42,591 | 42,591 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Polar Capital Holdings Plc | 56,585 | 35,585 | -21,000 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 10,858 | 34,083 | +23,225 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 29,558 | 29,558 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 23,800 | 23,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 22,856 | 22,856 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 32,097 | 22,493 | -9,604 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 21,480 | 21,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,837 | 20,837 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 0 | 20,328 | +20,328 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 19,781 | +19,781 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 21,972 | 19,726 | -2,246 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 9,727 | 18,775 | +9,048 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 19,143 | 18,504 | -639 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 3,396 | 18,128 | +14,732 | 0.00 | 0.00 | +0.00 | buy |
| TAKEDA PHARMACEUTICAL CO LTD | 16,515 | 16,515 | 0 | 0.01 | 0.08 | +0.07 | hold |
| Amundi | 14,497 | 14,497 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 38,432 | 13,832 | -24,600 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE TRADING, LLC | 0 | 13,808 | +13,808 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 13,002 | +13,002 | 0.00 | 0.00 | +0.00 | buy |