| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 71,254,677 | 71,254,677 | 0 | 9.17 | 8.34 | -0.83 | hold |
| VIKING GLOBAL INVESTORS LP | 58,651,170 | 58,651,170 | 0 | 0.41 | 0.33 | -0.08 | hold |
| BlackRock, Inc. | 22,452,115 | 24,857,850 | +2,405,735 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 17,292,092 | 17,156,146 | -135,946 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 15,245,461 | 16,850,345 | +1,604,884 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 6,984,232 | 7,081,711 | +97,479 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 6,949,717 | 6,975,221 | +25,504 | 0.00 | 0.00 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 9,578,563 | 6,618,394 | -2,960,169 | 0.01 | 0.01 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 9,572,492 | 6,618,394 | -2,954,098 | 0.21 | 0.12 | -0.08 | sell |
| Tikvah Management LLC | 6,551,058 | 6,551,058 | 0 | 3.92 | 3.12 | -0.80 | hold |
| STATE STREET CORP | 5,495,136 | 6,290,000 | +794,864 | 0.00 | 0.00 | +0.00 | buy |
| Hollow Brook Wealth Management LLC | 5,532,951 | 5,503,381 | -29,570 | 3.17 | 2.96 | -0.21 | sell |
| Neuberger Berman Group LLC | 4,729,846 | 4,580,053 | -149,793 | 0.01 | 0.01 | -0.00 | sell |
| ARK Investment Management LLC | 8,949,765 | 3,323,689 | -5,626,076 | 0.16 | 0.05 | -0.11 | sell |
| BARCLAYS PLC | 3,228,360 | 3,230,851 | +2,491 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 3,130,190 | +3,130,190 | 0.00 | 0.50 | +0.50 | buy |
| NORTHERN TRUST CORP | 2,631,638 | 2,875,160 | +243,522 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,445,083 | 2,332,649 | -112,434 | 0.00 | 0.00 | -0.00 | sell |
| Kent Lake PR LLC | 0 | 2,131,345 | +2,131,345 | 0.00 | 1.58 | +1.58 | buy |
| Nan Fung Group Holdings Ltd | 1,883,179 | 1,883,179 | 0 | 3.13 | 2.82 | -0.31 | hold |
| Slate Path Capital LP | 1,615,000 | 1,615,000 | 0 | 0.05 | 0.05 | -0.00 | hold |
| ROYCE & ASSOCIATES LP | 614,552 | 1,455,503 | +840,951 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 918,542 | 1,173,470 | +254,928 | 0.00 | 0.00 | +0.00 | buy |
| Pacific Capital Partners Ltd | 825,000 | 1,000,000 | +175,000 | 0.93 | 1.03 | +0.10 | buy |
| Bank of New York Mellon Corp | 755,468 | 740,190 | -15,278 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 991,704 | 735,004 | -256,700 | 0.00 | 0.00 | -0.00 | sell |
| NEEDHAM INVESTMENT MANAGEMENT LLC | 784,435 | 734,435 | -50,000 | 0.12 | 0.10 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,962,123 | 641,974 | -2,320,149 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 306,871 | 554,203 | +247,332 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 138,140 | 491,185 | +353,045 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 469,960 | 437,960 | -32,000 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 407,755 | 407,755 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Intellectus Partners, LLC | 419,702 | 404,702 | -15,000 | 0.21 | 0.16 | -0.05 | sell |
| UBS Group AG | 253,305 | 403,153 | +149,848 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 381,489 | 370,514 | -10,975 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 315,690 | 315,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 311,967 | 311,967 | 0 | 0.14 | 0.14 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 161,556 | 296,631 | +135,075 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 314,241 | 286,941 | -27,300 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 332,381 | 258,897 | -73,484 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 168,460 | 258,241 | +89,781 | 0.00 | 0.00 | +0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 550,000 | 248,400 | -301,600 | 0.05 | 0.02 | -0.03 | sell |
| CITIGROUP INC | 230,625 | 247,855 | +17,230 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 246,951 | 246,951 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANE STREET GROUP, LLC | 181,814 | 236,833 | +55,019 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 185,246 | 222,851 | +37,605 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 183,290 | 218,889 | +35,599 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 231,551 | 213,266 | -18,285 | 0.00 | 0.00 | -0.00 | sell |
| GM Advisory Group, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 143,325 | 183,382 | +40,057 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 164,993 | 181,468 | +16,475 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 140,362 | 181,256 | +40,894 | 0.00 | 0.00 | +0.00 | buy |
| Bradley & Co. Private Wealth Management, LLC | 223,939 | 179,364 | -44,575 | 0.29 | 0.20 | -0.10 | sell |
| Invesco Ltd. | 162,847 | 175,041 | +12,194 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 161,473 | 168,777 | +7,304 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 157,724 | 146,654 | -11,070 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,695 | 143,323 | +63,628 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 139,748 | 140,459 | +711 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 101,257 | 135,927 | +34,670 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 131,610 | 131,610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 129,734 | +129,734 | 0.00 | 0.02 | +0.02 | buy |
| Evercore Wealth Management, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 164,993 | 113,000 | -51,993 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 114,239 | 110,208 | -4,031 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 52,225 | 108,008 | +55,783 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 82,101 | 92,791 | +10,690 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 98,070 | 91,902 | -6,168 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 83,638 | 83,638 | 0 | 0.04 | 0.04 | -0.00 | hold |
| ProShare Advisors LLC | 55,740 | 83,074 | +27,334 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 82,610 | 79,997 | -2,613 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 79,000 | 79,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schoolcraft Capital LLC | 74,224 | 74,224 | 0 | 0.03 | 0.03 | -0.00 | hold |
| SEI INVESTMENTS CO | 63,497 | 65,769 | +2,272 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 69,330 | 64,433 | -4,897 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 50,330 | 50,330 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 87,174 | 50,187 | -36,987 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 20,328 | 47,278 | +26,950 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 45,881 | 44,562 | -1,319 | 0.00 | 0.00 | -0.00 | sell |
| Corvex Management LP | 44,400 | 44,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 42,591 | 42,591 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 95,006 | 35,004 | -60,002 | 0.00 | 0.00 | -0.00 | sell |
| SIMON QUICK ADVISORS, LLC | 0 | 31,091 | +31,091 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 29,558 | 29,558 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cresset Asset Management, LLC | 34,083 | 28,871 | -5,212 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 0 | 27,606 | +27,606 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 25,833 | +25,833 | 0.00 | 0.00 | +0.00 | buy |
| GAGNON SECURITIES LLC | 60,424 | 23,930 | -36,494 | 0.02 | 0.01 | -0.01 | sell |
| EverSource Wealth Advisors, LLC | 23,800 | 23,811 | +11 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 22,856 | 22,856 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,837 | 21,877 | +1,040 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 21,480 | 21,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XPONANCE, INC. | 18,504 | 20,275 | +1,771 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 19,781 | 19,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACKENZIE FINANCIAL CORP | 19,781 | 19,781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 22,493 | 18,849 | -3,644 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 0 | 17,341 | +17,341 | 0.00 | 0.01 | +0.01 | buy |
| TAKEDA PHARMACEUTICAL CO LTD | 16,515 | 16,515 | 0 | 0.08 | 0.11 | +0.02 | hold |
| CWM, LLC | 18,775 | 14,721 | -4,054 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 14,497 | 14,497 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 13,832 | 14,132 | +300 | 0.00 | 0.00 | -0.00 | buy |