| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Krensavage Asset Management, LLC | 1,498,074 | 2,117,390 | +619,316 | 8.70 | 7.20 | -1.49 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,108,262 | 2,108,262 | 0 | 0.12 | 0.06 | -0.06 | hold |
| BlackRock, Inc. | 1,900,323 | 2,039,642 | +139,319 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,981,866 | 1,984,164 | +2,298 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,102,852 | 1,221,595 | +118,743 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,038,000 | +1,038,000 | 0.00 | 0.08 | +0.08 | buy |
| MARSHALL WACE, LLP | 850,890 | 930,087 | +79,197 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 731,295 | 896,987 | +165,692 | 0.01 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 849,424 | 849,424 | 0 | 0.03 | 0.01 | -0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 524,900 | 498,000 | -26,900 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 477,351 | 477,231 | -120 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 449,975 | 460,984 | +11,009 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 501,372 | 421,594 | -79,778 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 536,705 | 387,376 | -149,329 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 331,900 | +331,900 | 0.00 | 1.54 | +1.54 | buy |
| DIMENSIONAL FUND ADVISORS LP | 194,460 | 297,106 | +102,646 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 191,726 | 290,011 | +98,285 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 143,806 | 192,856 | +49,050 | 0.00 | 0.00 | -0.00 | buy |
| Caligan Partners LP | 322,453 | 184,826 | -137,627 | 1.06 | 0.27 | -0.79 | sell |
| Sio Capital Management, LLC | 177,004 | 177,004 | 0 | 0.82 | 0.29 | -0.54 | hold |
| JPMORGAN CHASE & CO | 243,628 | 163,113 | -80,515 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 121,019 | 161,679 | +40,660 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 170,615 | 159,729 | -10,886 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 672,880 | 158,258 | -514,622 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 233,000 | 156,300 | -76,700 | 0.01 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 162,398 | 154,827 | -7,571 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 68,914 | 135,954 | +67,040 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 126,655 | 126,655 | 0 | 0.09 | 0.05 | -0.05 | hold |
| GOLDMAN SACHS GROUP INC | 160,133 | 123,861 | -36,272 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 149,425 | 85,649 | -63,776 | 0.05 | 0.01 | -0.03 | sell |
| FMR LLC | 49,301 | 77,584 | +28,283 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 72,925 | 72,789 | -136 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 35,409 | 71,104 | +35,695 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 328,311 | 70,427 | -257,884 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 191,257 | 64,283 | -126,974 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 157,064 | 60,364 | -96,700 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 58,127 | 57,120 | -1,007 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 34,751 | 51,298 | +16,547 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 43,428 | 46,614 | +3,186 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,000 | 46,200 | -1,800 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 37,859 | 46,099 | +8,240 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 27,438 | 45,508 | +18,070 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 44,102 | +44,102 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 40,700 | 40,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 36,165 | 37,091 | +926 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,461 | 36,962 | +3,501 | 0.00 | 0.00 | -0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 33,451 | +33,451 | 0.00 | 0.06 | +0.06 | buy |
| PDT Partners, LLC | 33,342 | 33,449 | +107 | 0.03 | 0.02 | -0.01 | buy |
| Portland Global Advisors LLC | 33,185 | 33,185 | 0 | 0.04 | 0.02 | -0.02 | hold |
| BANK OF MONTREAL /CAN/ | 0 | 31,748 | +31,748 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 30,726 | +30,726 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 29,940 | 29,940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 11,768 | 24,636 | +12,868 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 23,762 | +23,762 | 0.00 | 0.06 | +0.06 | buy |
| AlphaQuest LLC | 19,123 | 22,260 | +3,137 | 0.02 | 0.02 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 22,920 | 20,255 | -2,665 | 0.00 | 0.00 | -0.00 | sell |
| CIBC WORLD MARKET INC. | 0 | 18,727 | +18,727 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 18,346 | +18,346 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 16,038 | 17,137 | +1,099 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 43,899 | 16,679 | -27,220 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 16,535 | 16,335 | -200 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,363 | 15,881 | +6,518 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 7,225 | 15,726 | +8,501 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 14,677 | 15,527 | +850 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 17,520 | 14,416 | -3,104 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 0 | 13,000 | +13,000 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 0 | 11,558 | +11,558 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,931 | 11,471 | +540 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 10,701 | +10,701 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 10,349 | 10,347 | -2 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,092 | +10,092 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 10,741 | 9,987 | -754 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 88,128 | 8,534 | -79,594 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,771 | 7,771 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 4,928 | 7,202 | +2,274 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Trust, LLC | 5,064 | 5,064 | 0 | 0.01 | 0.01 | -0.01 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 4,658 | 4,658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 0 | 4,494 | +4,494 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 4,000 | 3,510 | -490 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 336 | 2,036 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,973 | 1,973 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,968 | 1,968 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,456 | 1,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 706 | +706 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 64 | 682 | +618 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 667 | 667 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 2,827 | 535 | -2,292 | 0.00 | 0.00 | -0.00 | sell |
| Sachetta, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 0 | 96 | +96 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 80 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 134 | 58 | -76 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 221 | 56 | -165 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,126 | 0 | -20,126 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 11,454 | 0 | -11,454 | 0.00 | 0.00 | -0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 1,906 | 0 | -1,906 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 1,322 | 0 | -1,322 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 128 | 0 | -128 | 0.00 | 0.00 | -0.00 | sell |