| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 13,485,903 | 15,309,860 | +1,823,957 | 0.19 | 0.26 | +0.07 | buy |
| BANK OF AMERICA CORP /DE/ | 418,552 | 1,064,573 | +646,021 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 500,000 | 1,000,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 558,490 | 913,792 | +355,302 | 0.02 | 0.05 | +0.02 | buy |
| VANGUARD GROUP INC | 12,733,399 | 13,056,605 | +323,206 | 0.05 | 0.06 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 300,635 | +300,635 | 0.00 | 0.23 | +0.23 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 270,924 | +270,924 | 0.00 | 0.12 | +0.12 | buy |
| TWO SIGMA ADVISERS, LP | 78,800 | 275,800 | +197,000 | 0.04 | 0.17 | +0.12 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 93,056 | 282,184 | +189,128 | 0.04 | 0.14 | +0.10 | buy |
| Capital Research Global Investors | 6,968,513 | 7,154,728 | +186,215 | 0.34 | 0.42 | +0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,319,385 | 3,505,168 | +185,783 | 0.09 | 0.12 | +0.03 | buy |
| SCS Capital Management LLC | 0 | 171,077 | +171,077 | 0.00 | 0.59 | +0.59 | buy |
| Winslow Capital Management, LLC | 1,020,567 | 1,187,178 | +166,611 | 0.85 | 1.28 | +0.43 | buy |
| Orbis Allan Gray Ltd | 1,472,802 | 1,634,923 | +162,121 | 1.86 | 2.53 | +0.66 | buy |
| Woodline Partners LP | 0 | 156,464 | +156,464 | 0.00 | 0.27 | +0.27 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,604,024 | 1,760,435 | +156,411 | 0.22 | 0.29 | +0.07 | buy |
| PRUDENTIAL FINANCIAL INC | 18,753 | 172,006 | +153,253 | 0.01 | 0.07 | +0.06 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 152,970 | +152,970 | 0.00 | 0.16 | +0.16 | buy |
| SEI INVESTMENTS CO | 99,000 | 251,000 | +152,000 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 16,600,525 | 16,749,623 | +149,098 | 0.59 | 0.73 | +0.14 | buy |
| 1832 Asset Management L.P. | 0 | 144,045 | +144,045 | 0.00 | 0.07 | +0.07 | buy |
| SG Americas Securities, LLC | 1,667 | 132,960 | +131,293 | 0.00 | 0.12 | +0.12 | buy |
| GOLDMAN SACHS GROUP INC | 306,455 | 423,367 | +116,912 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,206,800 | 2,322,834 | +116,034 | 0.04 | 0.05 | +0.01 | buy |
| Allianz Asset Management GmbH | 108,871 | 218,503 | +109,632 | 0.04 | 0.09 | +0.05 | buy |
| CITIGROUP INC | 86,897 | 194,734 | +107,837 | 0.02 | 0.04 | +0.02 | buy |
| FIL Ltd | 22,066 | 117,862 | +95,796 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 107,117 | 197,415 | +90,298 | 0.06 | 0.12 | +0.06 | buy |
| PFM Health Sciences, LP | 0 | 87,145 | +87,145 | 0.00 | 1.80 | +1.80 | buy |
| J. Goldman & Co LP | 0 | 74,185 | +74,185 | 0.00 | 0.71 | +0.71 | buy |
| Sofinnova Investments, Inc. | 110,157 | 176,181 | +66,024 | 1.90 | 3.59 | +1.69 | buy |
| Iron Triangle Partners LP | 0 | 65,409 | +65,409 | 0.00 | 2.78 | +2.78 | buy |
| Handelsbanken Fonder AB | 54,346 | 116,683 | +62,337 | 0.05 | 0.13 | +0.08 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 60,000 | +60,000 | 0.00 | 0.29 | +0.29 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,817 | 70,465 | +59,648 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 73,160 | 129,196 | +56,036 | 0.02 | 0.05 | +0.02 | buy |
| Legal & General Group Plc | 828,917 | 881,111 | +52,194 | 0.05 | 0.06 | +0.01 | buy |
| Pictet Asset Management Holding SA | 430,612 | 480,967 | +50,355 | 0.11 | 0.14 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 259,913 | 309,219 | +49,306 | 0.04 | 0.06 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 16,776 | 62,302 | +45,526 | 0.01 | 0.06 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 414,139 | 458,314 | +44,175 | 0.03 | 0.04 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 55,464 | 96,804 | +41,340 | 0.06 | 0.13 | +0.07 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 150,191 | 191,105 | +40,914 | 0.23 | 0.33 | +0.10 | buy |
| T. Rowe Price Investment Management, Inc. | 4,384,449 | 4,418,145 | +33,696 | 0.64 | 0.79 | +0.15 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 513,962 | 546,642 | +32,680 | 0.02 | 0.03 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 31,594 | +31,594 | 0.00 | 2.78 | +2.78 | buy |
| Rhenman & Partners Asset Management AB | 17,000 | 48,197 | +31,197 | 0.41 | 1.50 | +1.08 | buy |
| Parkman Healthcare Partners LLC | 38,672 | 68,938 | +30,266 | 1.21 | 2.21 | +1.00 | buy |
| ROYAL BANK OF CANADA | 310,187 | 337,231 | +27,044 | 0.02 | 0.02 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 133,759 | 159,554 | +25,795 | 1.09 | 1.35 | +0.26 | buy |
| Mediolanum International Funds Ltd | 9,063 | 34,729 | +25,666 | 0.03 | 0.13 | +0.10 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 710,598 | 736,111 | +25,513 | 0.04 | 0.05 | +0.01 | buy |
| Aberdeen Group plc | 190,841 | 215,385 | +24,544 | 0.08 | 0.11 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,378 | 34,701 | +24,323 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 33,480 | 57,128 | +23,648 | 0.07 | 0.15 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 276,962 | 300,080 | +23,118 | 0.02 | 0.02 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 22,262 | +22,262 | 0.00 | 0.06 | +0.06 | buy |
| Cercano Management LLC | 0 | 20,772 | +20,772 | 0.00 | 0.16 | +0.16 | buy |
| DEUTSCHE BANK AG\ | 556,579 | 576,993 | +20,414 | 0.05 | 0.06 | +0.01 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 19,821 | +19,821 | 0.00 | 0.22 | +0.22 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 19,200 | +19,200 | 0.00 | 1.36 | +1.36 | buy |
| Quadrature Capital Ltd | 0 | 18,511 | +18,511 | 0.00 | 0.11 | +0.11 | buy |
| Investment Management Corp of Ontario | 7,099 | 23,277 | +16,178 | 0.06 | 0.13 | +0.07 | buy |
| Point72 Europe (London) LLP | 0 | 15,958 | +15,958 | 0.00 | 0.30 | +0.30 | buy |
| Jefferies Financial Group Inc. | 0 | 15,347 | +15,347 | 0.00 | 0.07 | +0.07 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 15,006 | +15,006 | 0.00 | 1.06 | +1.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 813,356 | 828,344 | +14,988 | 0.25 | 0.22 | -0.02 | buy |
| FEDERATED HERMES, INC. | 249,591 | 264,173 | +14,582 | 0.13 | 0.15 | +0.03 | buy |
| National Pension Service | 159,511 | 173,659 | +14,148 | 0.04 | 0.05 | +0.01 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 10,018 | 23,763 | +13,745 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,116 | +13,116 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 13,115 | +13,115 | 0.00 | 2.83 | +2.83 | buy |
| AVIVA PLC | 77,244 | 90,053 | +12,809 | 0.05 | 0.06 | +0.01 | buy |
| Korea Investment CORP | 93,603 | 105,759 | +12,156 | 0.05 | 0.07 | +0.02 | buy |
| MACQUARIE GROUP LTD | 60,664 | 72,592 | +11,928 | 0.02 | 0.02 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 1,763 | 13,644 | +11,881 | 0.00 | 0.04 | +0.04 | buy |
| GROUPAMA ASSET MANAGMENT | 28,450 | 40,139 | +11,689 | 0.17 | 0.25 | +0.08 | buy |
| SEI INVESTMENTS CO | 266,000 | 277,369 | +11,369 | 0.08 | 0.10 | +0.02 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 94,698 | 105,879 | +11,181 | 0.02 | 0.03 | +0.00 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 4,529 | 15,302 | +10,773 | 0.07 | 0.35 | +0.28 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 10,090 | +10,090 | 0.00 | 0.09 | +0.09 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 9,370 | +9,370 | 0.00 | 0.10 | +0.10 | buy |
| TB Alternative Assets Ltd. | 0 | 9,168 | +9,168 | 0.00 | 0.58 | +0.58 | buy |
| Kentucky Retirement Systems | 0 | 8,794 | +8,794 | 0.00 | 0.07 | +0.07 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 8,400 | +8,400 | 0.00 | 0.55 | +0.55 | buy |
| SIH Partners, LLLP | 0 | 7,959 | +7,959 | 0.00 | 0.19 | +0.19 | buy |
| Verition Fund Management LLC | 2,903 | 10,779 | +7,876 | 0.00 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 0 | 7,777 | +7,777 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 10,313 | 17,804 | +7,491 | 0.43 | 0.83 | +0.41 | buy |
| Advisory Services Network, LLC | 6,268 | 13,516 | +7,248 | 0.03 | 0.07 | +0.04 | buy |
| Twin Tree Management, LP | 0 | 7,074 | +7,074 | 0.00 | 0.04 | +0.04 | buy |
| CANADA LIFE ASSURANCE Co | 76,919 | 83,828 | +6,909 | 0.03 | 0.04 | +0.01 | buy |
| Federation des caisses Desjardins du Quebec | 2,644 | 9,422 | +6,778 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 18,240 | 24,862 | +6,622 | 0.23 | 0.53 | +0.30 | buy |
| Jain Global LLC | 0 | 6,221 | +6,221 | 0.00 | 0.03 | +0.03 | buy |
| GROUP ONE TRADING LLC | 0 | 6,202 | +6,202 | 0.00 | 0.07 | +0.07 | buy |
| Tredje AP-fonden | 9,742 | 15,907 | +6,165 | 0.02 | 0.04 | +0.02 | buy |
| Genus Capital Management Inc. | 0 | 6,130 | +6,130 | 0.00 | 0.24 | +0.24 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 66,014 | 72,047 | +6,033 | 0.00 | 0.01 | +0.00 | buy |
| Capital International Sarl | 115,142 | 121,160 | +6,018 | 0.63 | 0.74 | +0.12 | buy |