| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,655,795 | 9,164,538 | +508,743 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 6,046,520 | 6,020,492 | -26,028 | 0.01 | 0.01 | +0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 2,253,788 | 3,376,928 | +1,123,140 | 0.14 | 0.29 | +0.15 | buy |
| JANUS HENDERSON GROUP PLC | 1,065,209 | 3,018,787 | +1,953,578 | 0.04 | 0.15 | +0.11 | buy |
| STATE STREET CORP | 2,104,362 | 2,122,402 | +18,040 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,900,284 | 2,104,294 | +204,010 | 0.04 | 0.05 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,733,474 | 1,643,448 | -90,026 | 0.04 | 0.06 | +0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 913,410 | 1,609,699 | +696,289 | 0.06 | 0.13 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 436,967 | 1,350,425 | +913,458 | 0.01 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,316,087 | 1,317,648 | +1,561 | 0.01 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 547,052 | 1,299,294 | +752,242 | 0.10 | 0.31 | +0.21 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,093,744 | 1,106,918 | +13,174 | 0.23 | 0.35 | +0.12 | buy |
| BRAIDWELL LP | 780,164 | 921,979 | +141,815 | 1.89 | 3.33 | +1.44 | buy |
| UBS Group AG | 210,093 | 873,942 | +663,849 | 0.00 | 0.02 | +0.02 | buy |
| Capital World Investors | 850,893 | 850,893 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Invesco Ltd. | 607,442 | 780,267 | +172,825 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 702,380 | 714,026 | +11,646 | 0.01 | 0.01 | +0.00 | buy |
| Artisan Partners Limited Partnership | 293,665 | 702,818 | +409,153 | 0.03 | 0.12 | +0.09 | buy |
| MORGAN STANLEY | 429,578 | 670,778 | +241,200 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 627,660 | 587,130 | -40,530 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 278,435 | 558,290 | +279,855 | 0.02 | 0.05 | +0.03 | buy |
| JPMORGAN CHASE & CO | 670,083 | 556,479 | -113,604 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 474,930 | 538,678 | +63,748 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 536,143 | +536,143 | 0.00 | 0.01 | +0.01 | buy |
| RIVERBRIDGE PARTNERS LLC | 569,644 | 535,169 | -34,475 | 0.78 | 1.13 | +0.35 | sell |
| Capital International Investors | 511,510 | 511,510 | 0 | 0.01 | 0.01 | +0.00 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 3,580,670 | 486,824 | -3,093,846 | 0.05 | 0.01 | -0.04 | sell |
| AustralianSuper Pty Ltd | 449,846 | 449,846 | 0 | 0.17 | 0.24 | +0.06 | hold |
| LOOMIS SAYLES & CO L P | 447,429 | 447,805 | +376 | 0.04 | 0.06 | +0.02 | buy |
| Nuveen, LLC | 162,029 | 406,046 | +244,017 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 381,394 | 355,840 | -25,554 | 0.01 | 0.01 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 267,498 | 355,279 | +87,781 | 0.04 | 0.06 | +0.03 | buy |
| Champlain Investment Partners, LLC | 358,419 | 333,264 | -25,155 | 0.22 | 0.38 | +0.16 | sell |
| BROWN CAPITAL MANAGEMENT LLC | 762,760 | 326,579 | -436,181 | 2.56 | 3.02 | +0.46 | sell |
| FRED ALGER MANAGEMENT, LLC | 316,804 | 325,540 | +8,736 | 0.10 | 0.14 | +0.04 | buy |
| Integral Health Asset Management, LLC | 100,000 | 325,000 | +225,000 | 0.59 | 1.86 | +1.27 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 289,275 | 289,275 | 0 | 0.39 | 0.51 | +0.12 | hold |
| Sofinnova Investments, Inc. | 312,994 | 288,128 | -24,866 | 1.57 | 1.40 | -0.16 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 277,202 | 274,565 | -2,637 | 0.01 | 0.02 | +0.00 | sell |
| Bellevue Group AG | 55,926 | 261,935 | +206,009 | 0.09 | 0.56 | +0.47 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 28,582 | 250,000 | +221,418 | 0.00 | 0.04 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 230,000 | 210,000 | -20,000 | 2.08 | 2.22 | +0.14 | sell |
| C WorldWide Group Holding A/S | 207,212 | 207,212 | 0 | 0.26 | 0.41 | +0.15 | hold |
| DIMENSIONAL FUND ADVISORS LP | 241,680 | 205,461 | -36,219 | 0.00 | 0.00 | +0.00 | sell |
| PFM Health Sciences, LP | 0 | 201,676 | +201,676 | 0.00 | 2.31 | +2.31 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 223,708 | 198,817 | -24,891 | 0.07 | 0.08 | +0.01 | sell |
| ROYAL BANK OF CANADA | 369,439 | 191,900 | -177,539 | 0.01 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 128,210 | 189,832 | +61,622 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 367,528 | 188,735 | -178,793 | 0.04 | 0.03 | -0.01 | sell |
| Assenagon Asset Management S.A. | 157,545 | 182,393 | +24,848 | 0.02 | 0.03 | +0.01 | buy |
| SEI INVESTMENTS CO | 148,108 | 181,853 | +33,745 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 189,276 | 179,698 | -9,578 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 690,723 | 161,596 | -529,127 | 0.12 | 0.03 | -0.09 | sell |
| ALGERT GLOBAL LLC | 34,441 | 155,546 | +121,105 | 0.05 | 0.27 | +0.23 | buy |
| GILDER GAGNON HOWE & CO LLC | 334,532 | 154,442 | -180,090 | 0.28 | 0.18 | -0.09 | sell |
| RHUMBLINE ADVISERS | 157,697 | 151,467 | -6,230 | 0.01 | 0.01 | +0.00 | sell |
| Eversept Partners, LP | 0 | 147,471 | +147,471 | 0.00 | 0.93 | +0.93 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 145,621 | 143,192 | -2,429 | 0.00 | 0.00 | +0.00 | sell |
| KEYBANK NATIONAL ASSOCIATION/OH | 142,447 | 142,506 | +59 | 0.04 | 0.06 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 140,000 | +140,000 | 0.00 | 0.29 | +0.29 | buy |
| SEGALL BRYANT & HAMILL, LLC | 125,490 | 131,404 | +5,914 | 0.14 | 0.20 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 116,906 | 122,169 | +5,263 | 0.00 | 0.00 | +0.00 | buy |
| Granite Investment Partners, LLC | 137,347 | 119,343 | -18,004 | 0.64 | 0.80 | +0.16 | sell |
| Swiss National Bank | 110,700 | 113,100 | +2,400 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 471,552 | 112,022 | -359,530 | 0.03 | 0.01 | -0.02 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 101,447 | 104,279 | +2,832 | 0.05 | 0.08 | +0.03 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 142,288 | 101,613 | -40,675 | 0.52 | 0.49 | -0.04 | sell |
| RAYMOND JAMES FINANCIAL INC | 107,815 | 98,768 | -9,047 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 66,939 | 98,651 | +31,712 | 0.01 | 0.02 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 102,887 | 97,367 | -5,520 | 0.02 | 0.02 | +0.01 | sell |
| BARCLAYS PLC | 91,152 | 91,127 | -25 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 87,171 | +87,171 | 0.00 | 0.02 | +0.02 | buy |
| DnB Asset Management AS | 73,550 | 82,320 | +8,770 | 0.02 | 0.03 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 97,307 | 80,102 | -17,205 | 0.00 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 52,174 | 79,610 | +27,436 | 0.01 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 72,353 | 72,340 | -13 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 40,808 | 69,175 | +28,367 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 61,700 | 69,000 | +7,300 | 0.01 | 0.02 | +0.01 | buy |
| SIT INVESTMENT ASSOCIATES INC | 68,630 | 66,970 | -1,660 | 0.11 | 0.15 | +0.04 | sell |
| SG Americas Securities, LLC | 10,740 | 60,232 | +49,492 | 0.00 | 0.01 | +0.01 | buy |
| Capricorn Fund Managers Ltd | 0 | 60,000 | +60,000 | 0.00 | 1.63 | +1.63 | buy |
| Allianz Asset Management GmbH | 58,654 | 55,996 | -2,658 | 0.01 | 0.01 | +0.00 | sell |
| Baird Financial Group, Inc. | 58,849 | 55,434 | -3,415 | 0.01 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,784 | 54,563 | +779 | 0.00 | 0.01 | +0.00 | buy |
| Neuberger Berman Group LLC | 50,801 | 53,778 | +2,977 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 57,647 | 53,557 | -4,090 | 0.01 | 0.01 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 55,883 | 51,833 | -4,050 | 0.00 | 0.00 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 51,600 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 61,348 | 50,101 | -11,247 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 48,243 | 48,243 | 0 | 0.01 | 0.01 | +0.00 | hold |
| THORNBURG INVESTMENT MANAGEMENT INC | 49,069 | 47,725 | -1,344 | 0.05 | 0.07 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 44,710 | 46,731 | +2,021 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 21,912 | 44,623 | +22,711 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 50,095 | 43,615 | -6,480 | 0.04 | 0.04 | +0.01 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 31,175 | 42,996 | +11,821 | 0.00 | 0.01 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,500 | +40,500 | 0.00 | 2.21 | +2.21 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 41,374 | 39,465 | -1,909 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,162 | 39,141 | -1,021 | 0.01 | 0.01 | +0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 35,926 | 32,342 | -3,584 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 16,068 | 31,806 | +15,738 | 0.00 | 0.00 | +0.00 | buy |