| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 9,500,000 | 12,600,000 | +3,100,000 | 5.69 | 6.22 | +0.53 | buy |
| Casdin Capital, LLC | 8,100,000 | 7,200,000 | -900,000 | 1.78 | 1.60 | -0.18 | sell |
| BlackRock, Inc. | 7,584,787 | 7,135,938 | -448,849 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,569,425 | 4,610,357 | +40,932 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,724,941 | 4,589,213 | -135,728 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 606,294 | 4,200,950 | +3,594,656 | 0.00 | 0.02 | +0.01 | buy |
| Nantahala Capital Management, LLC | 2,830,619 | 4,030,619 | +1,200,000 | 0.63 | 0.70 | +0.07 | buy |
| Telemark Asset Management, LLC | 3,000,000 | 4,000,000 | +1,000,000 | 1.06 | 1.04 | -0.02 | buy |
| AMERIPRISE FINANCIAL INC | 2,534,707 | 2,550,806 | +16,099 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,925,281 | 1,977,869 | +52,588 | 0.00 | 0.00 | -0.00 | buy |
| Pier Capital, LLC | 1,669,204 | 1,915,160 | +245,956 | 0.75 | 0.71 | -0.04 | buy |
| BAILLIE GIFFORD & CO | 1,699,644 | 1,685,664 | -13,980 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,647,237 | 1,613,338 | -33,899 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,070,253 | 1,178,131 | +107,878 | 0.01 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1,087,951 | 872,814 | -215,137 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 650,786 | 755,486 | +104,700 | 0.00 | 0.00 | -0.00 | buy |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 568,974 | 700,591 | +131,617 | 0.22 | 0.20 | -0.02 | buy |
| NORTHERN TRUST CORP | 663,045 | 659,158 | -3,887 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 458,616 | 572,139 | +113,523 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 342,660 | 522,913 | +180,253 | 0.01 | 0.01 | +0.00 | buy |
| Post Resch Tallon Group Inc. | 468,587 | 467,301 | -1,286 | 1.18 | 1.10 | -0.08 | sell |
| GOLDMAN SACHS GROUP INC | 309,086 | 448,770 | +139,684 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 269,193 | 447,526 | +178,333 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 437,126 | 414,419 | -22,707 | 0.00 | 0.00 | -0.00 | sell |
| Mink Brook Asset Management LLC | 126,642 | 321,711 | +195,069 | 0.36 | 0.68 | +0.32 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 316,383 | 316,383 | 0 | 0.05 | 0.05 | +0.00 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 318,800 | 312,000 | -6,800 | 0.90 | 0.77 | -0.14 | sell |
| Nuveen, LLC | 1,248,263 | 300,852 | -947,411 | 0.00 | 0.00 | -0.00 | sell |
| Empire Financial Management Company, LLC | 295,000 | 295,000 | 0 | 0.25 | 0.21 | -0.04 | hold |
| BARCLAYS PLC | 198,134 | 253,639 | +55,505 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,250 | 250,726 | +476 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 602,288 | 229,697 | -372,591 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 224,390 | 207,800 | -16,590 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 220,125 | 180,665 | -39,460 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 291,985 | 174,151 | -117,834 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 126,103 | 162,912 | +36,809 | 0.04 | 0.04 | +0.00 | buy |
| WHITE PINE CAPITAL LLC | 195,081 | 137,749 | -57,332 | 0.18 | 0.11 | -0.08 | sell |
| RHUMBLINE ADVISERS | 107,659 | 135,556 | +27,897 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 117,815 | 118,130 | +315 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 117,002 | +117,002 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 107,100 | 115,300 | +8,200 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 217,673 | 111,848 | -105,825 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 102,378 | +102,378 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 94,608 | 100,908 | +6,300 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 67,447 | 96,078 | +28,631 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 78,032 | 84,556 | +6,524 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 395,234 | 82,037 | -313,197 | 0.00 | 0.00 | -0.00 | sell |
| CLOUGH CAPITAL PARTNERS L P | 69,000 | 69,000 | 0 | 0.02 | 0.02 | -0.01 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 380,950 | 68,402 | -312,548 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 19,816 | 50,349 | +30,533 | 0.00 | 0.00 | +0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 50,000 | 50,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 64,485 | 48,395 | -16,090 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 47,492 | +47,492 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 46,713 | 46,713 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 99,500 | 46,000 | -53,500 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 47,634 | 45,606 | -2,028 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 48,262 | 44,193 | -4,069 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 49,509 | 42,811 | -6,698 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 46,643 | 42,101 | -4,542 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 50,837 | 42,029 | -8,808 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34,199 | 40,497 | +6,298 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 42,121 | 39,991 | -2,130 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 46,935 | 38,036 | -8,899 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 36,830 | 36,830 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 32,908 | 33,648 | +740 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 57,549 | 31,265 | -26,284 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,392 | 29,775 | +1,383 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 40,468 | 28,713 | -11,755 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 21,899 | 23,124 | +1,225 | 0.00 | 0.00 | -0.00 | buy |
| Elmwood Wealth Management, Inc. | 0 | 21,695 | +21,695 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 21,177 | 19,883 | -1,294 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 19,441 | 19,441 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 31,082 | 17,104 | -13,978 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,888 | 16,888 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 16,616 | 16,639 | +23 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 17,960 | 16,200 | -1,760 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 13,643 | 13,643 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIDUCIARY TRUST CO | 13,620 | 13,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 11,708 | 10,536 | -1,172 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 0 | 10,443 | +10,443 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 17,876 | 10,088 | -7,788 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,649 | 9,950 | +7,301 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,946 | 9,138 | +7,192 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,046 | 8,570 | +3,524 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 7,349 | 8,500 | +1,151 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,428 | 8,428 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,931 | 5,931 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 4,346 | 5,768 | +1,422 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,772 | 3,200 | +428 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,780 | 2,780 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,726 | 2,276 | -2,450 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,019 | 2,019 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 4,200 | 1,800 | -2,400 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,075 | 973 | -102 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 972 | 972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 1,242 | 567 | -675 | 0.00 | 0.00 | -0.00 | sell |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Physician Wealth Advisors, Inc. | 0 | 442 | +442 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 269 | 379 | +110 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 350 | 350 | 0 | 0.00 | 0.00 | -0.00 | hold |