| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 3,455,000 | 8,770,000 | +5,315,000 | 2.45 | 4.51 | +2.06 | buy |
| Casdin Capital, LLC | 2,000,000 | 8,100,000 | +6,100,000 | 0.47 | 1.66 | +1.19 | buy |
| FMR LLC | 4,445,268 | 4,497,090 | +51,822 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,091,230 | 4,152,719 | +61,489 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 3,629,622 | 2,967,808 | -661,814 | 1.13 | 0.77 | -0.36 | sell |
| Telemark Asset Management, LLC | 2,696,411 | 2,696,411 | 0 | 0.76 | 0.84 | +0.08 | hold |
| AMERIPRISE FINANCIAL INC | 2,002,745 | 2,387,025 | +384,280 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 2,708,802 | 1,813,800 | -895,002 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,632,957 | 1,644,039 | +11,082 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,509,931 | 1,551,411 | +41,480 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 71,925 | 1,400,059 | +1,328,134 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,254,465 | 1,256,359 | +1,894 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 894,235 | 1,103,442 | +209,207 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,009,889 | 895,695 | -114,194 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 492,648 | 800,410 | +307,762 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 669,623 | 740,137 | +70,514 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 588,759 | 589,933 | +1,174 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 479,270 | 555,139 | +75,869 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 632,500 | 485,100 | -147,400 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 340,762 | 408,942 | +68,180 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 406,462 | +406,462 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 388,144 | 388,144 | 0 | 0.11 | 0.10 | -0.01 | hold |
| AQR CAPITAL MANAGEMENT LLC | 237,272 | 314,460 | +77,188 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 275,241 | 278,699 | +3,458 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 251,372 | 268,793 | +17,421 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 334,900 | 256,821 | -78,079 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 242,000 | 242,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 237,174 | 237,174 | 0 | 0.11 | 0.11 | -0.01 | hold |
| Empire Financial Management Company, LLC | 212,952 | 222,952 | +10,000 | 0.22 | 0.21 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,567 | 213,668 | +101 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 137,373 | 207,628 | +70,255 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 284,166 | 203,447 | -80,719 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 200,063 | 200,063 | 0 | 0.03 | 0.03 | +0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 216,286 | 199,172 | -17,114 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 173,280 | 188,660 | +15,380 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 244,340 | 177,669 | -66,671 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 278,652 | 172,186 | -106,466 | 0.00 | 0.00 | -0.00 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 159,600 | 164,100 | +4,500 | 0.47 | 0.47 | +0.01 | buy |
| STRS OHIO | 161,800 | 161,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WHITE PINE CAPITAL LLC | 117,944 | 151,424 | +33,480 | 0.14 | 0.16 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 349,490 | 125,916 | -223,574 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 107,950 | 110,965 | +3,015 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 100,734 | 109,085 | +8,351 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 108,594 | 104,178 | -4,416 | 0.00 | 0.00 | -0.00 | sell |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 900,000 | 100,000 | -800,000 | 0.13 | 0.01 | -0.11 | sell |
| GSA CAPITAL PARTNERS LLP | 54,292 | 99,629 | +45,337 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 74,531 | 93,594 | +19,063 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 131,001 | 79,584 | -51,417 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 135,511 | 77,100 | -58,411 | 0.01 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 77,692 | 59,342 | -18,350 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 58,294 | 58,294 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 99,686 | 58,093 | -41,593 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 15,886 | 51,335 | +35,449 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 107,891 | 40,005 | -67,886 | 0.01 | 0.00 | -0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,794 | 38,222 | +2,428 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 37,579 | 37,349 | -230 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 41,556 | 37,165 | -4,391 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 36,677 | 36,978 | +301 | 0.00 | 0.00 | -0.00 | buy |
| BLAIR WILLIAM & CO/IL | 35,880 | 36,830 | +950 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 25,052 | 35,134 | +10,082 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 30,757 | 33,304 | +2,547 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 30,763 | 31,908 | +1,145 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 31,468 | +31,468 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 29,456 | 29,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,976 | 27,881 | -1,095 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 28,263 | 26,953 | -1,310 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 23,922 | 25,663 | +1,741 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,794 | 22,720 | +1,926 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 21,354 | +21,354 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,195 | 17,591 | -21,604 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 17,480 | 17,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,888 | 16,888 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 13,043 | 15,329 | +2,286 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 103,019 | 13,762 | -89,257 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 13,643 | 13,643 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ProShare Advisors LLC | 0 | 13,199 | +13,199 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 12,627 | +12,627 | 0.00 | 0.00 | +0.00 | buy |
| Miller Investment Management, LP | 11,693 | 11,693 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Worth Venture Partners, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.23 | +0.23 | buy |
| Legal & General Group Plc | 6,162 | 6,162 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 3,860 | 5,150 | +1,290 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,061 | 5,061 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,645 | 4,645 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 7,248 | 4,115 | -3,133 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 5,303 | 3,904 | -1,399 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,386 | 3,493 | -893 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 3,400 | 3,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 2,084 | 2,084 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,902 | 1,798 | -104 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 0 | 1,341 | +1,341 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 1,124 | 1,124 | 0 | 0.00 | 0.00 | -0.00 | hold |
| nVerses Capital, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 972 | 972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 0 | 514 | +514 | 0.00 | 0.00 | +0.00 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arax Advisory Partners | 424 | 424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMPLEX TRADING, LLC | 1,446 | 409 | -1,037 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 0 | 406 | +406 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 350 | 350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |