| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 8,770,000 | 8,840,000 | +70,000 | 4.51 | 7.38 | +2.87 | buy |
| Casdin Capital, LLC | 8,100,000 | 8,100,000 | 0 | 1.66 | 2.58 | +0.92 | hold |
| BlackRock, Inc. | 6,915,734 | 7,642,607 | +726,873 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,497,090 | 4,526,590 | +29,500 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,152,719 | 4,463,801 | +311,082 | 0.00 | 0.00 | +0.00 | buy |
| Telemark Asset Management, LLC | 2,696,411 | 3,000,000 | +303,589 | 0.84 | 1.43 | +0.59 | buy |
| Nantahala Capital Management, LLC | 2,967,808 | 2,841,660 | -126,148 | 0.77 | 0.95 | +0.18 | sell |
| AMERIPRISE FINANCIAL INC | 2,387,025 | 2,399,650 | +12,625 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,644,039 | 1,855,514 | +211,475 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 1,813,800 | 1,694,025 | -119,775 | 0.00 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 1,551,411 | 1,612,911 | +61,500 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,256,359 | 1,278,126 | +21,767 | 0.01 | 0.01 | +0.00 | buy |
| CenterBook Partners LP | 0 | 982,848 | +982,848 | 0.00 | 0.28 | +0.28 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 895,695 | 860,955 | -34,740 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 406,462 | 709,772 | +303,310 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 589,933 | 688,189 | +98,256 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 555,139 | 527,623 | -27,516 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 800,410 | 508,623 | -291,787 | 0.00 | 0.00 | +0.00 | sell |
| Kent Lake PR LLC | 1,000,000 | 500,000 | -500,000 | 1.22 | 1.01 | -0.21 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 740,137 | 483,732 | -256,405 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 408,942 | 405,975 | -2,967 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 485,100 | 403,700 | -81,400 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 268,793 | 350,082 | +81,289 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 199,172 | 309,713 | +110,541 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 125,916 | 299,143 | +173,227 | 0.00 | 0.01 | +0.00 | buy |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 237,174 | 297,174 | +60,000 | 0.11 | 0.19 | +0.09 | buy |
| Assenagon Asset Management S.A. | 1,103,442 | 287,864 | -815,578 | 0.01 | 0.00 | -0.00 | sell |
| Private Advisor Group, LLC | 278,699 | 281,043 | +2,344 | 0.01 | 0.01 | +0.00 | buy |
| Empire Financial Management Company, LLC | 222,952 | 270,000 | +47,048 | 0.21 | 0.40 | +0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 256,821 | 263,218 | +6,397 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,668 | 239,720 | +26,052 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 207,628 | 237,176 | +29,548 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 242,000 | 236,008 | -5,992 | 0.02 | 0.03 | +0.01 | sell |
| LPL Financial LLC | 188,660 | 223,995 | +35,335 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 203,447 | 220,876 | +17,429 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 200,063 | 200,063 | 0 | 0.03 | 0.06 | +0.03 | hold |
| WHITE PINE CAPITAL LLC | 151,424 | 193,936 | +42,512 | 0.16 | 0.31 | +0.15 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 164,100 | 188,350 | +24,250 | 0.47 | 0.80 | +0.32 | buy |
| JPMORGAN CHASE & CO | 31,468 | 183,906 | +152,438 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 182,223 | +182,223 | 0.00 | 0.12 | +0.12 | buy |
| FRANKLIN RESOURCES INC | 29,456 | 177,101 | +147,645 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 176,748 | +176,748 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 104,178 | 115,080 | +10,902 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 110,965 | 110,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 109,085 | 107,983 | -1,102 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 161,800 | 107,100 | -54,700 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 58,093 | 106,365 | +48,272 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 314,460 | 103,631 | -210,829 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 0 | 84,988 | +84,988 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 76,305 | +76,305 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 58,294 | 75,951 | +17,657 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 177,669 | 74,340 | -103,329 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 51,335 | 62,677 | +11,342 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 77,100 | 60,046 | -17,054 | 0.00 | 0.00 | +0.00 | sell |
| Numerai GP LLC | 0 | 54,476 | +54,476 | 0.00 | 0.07 | +0.07 | buy |
| Squarepoint Ops LLC | 93,594 | 53,067 | -40,527 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 59,342 | 52,300 | -7,042 | 0.00 | 0.00 | +0.00 | sell |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 100,000 | 50,000 | -50,000 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 35,134 | 48,172 | +13,038 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 31,908 | 47,211 | +15,303 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,591 | 46,160 | +28,569 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,222 | 45,606 | +7,384 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 79,584 | 45,348 | -34,236 | 0.00 | 0.00 | -0.00 | sell |
| JACKSON SQUARE CAPITAL, LLC | 0 | 43,996 | +43,996 | 0.00 | 0.05 | +0.05 | buy |
| STIFEL FINANCIAL CORP | 172,186 | 41,673 | -130,513 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 37,349 | 40,052 | +2,703 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 36,830 | 36,830 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Centiva Capital, LP | 0 | 36,329 | +36,329 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 36,978 | 35,938 | -1,040 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,400,059 | 35,931 | -1,364,128 | 0.00 | 0.00 | -0.00 | sell |
| CLOUGH CAPITAL PARTNERS L P | 0 | 35,600 | +35,600 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 33,304 | 33,731 | +427 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 21,354 | 33,111 | +11,757 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,720 | 31,552 | +8,832 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,881 | 27,563 | -318 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 26,953 | 26,953 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ProShare Advisors LLC | 13,199 | 26,543 | +13,344 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 25,663 | 22,282 | -3,381 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 0 | 17,255 | +17,255 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,888 | 16,888 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OSAIC HOLDINGS, INC. | 0 | 16,634 | +16,634 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 16,600 | +16,600 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 17,480 | 15,620 | -1,860 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 0 | 15,226 | +15,226 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 15,329 | 15,200 | -129 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 13,643 | 13,643 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIDUCIARY TRUST CO | 0 | 13,620 | +13,620 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 12,627 | 12,558 | -69 | 0.00 | 0.00 | +0.00 | sell |
| WOLVERINE TRADING, LLC | 0 | 12,010 | +12,010 | 0.00 | 0.00 | +0.00 | buy |
| Miller Investment Management, LP | 11,693 | 11,693 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 13,762 | 9,977 | -3,785 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 4,645 | 8,428 | +3,783 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,162 | 7,349 | +1,187 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,061 | 5,931 | +870 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,115 | 5,426 | +1,311 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 4,986 | +4,986 | 0.00 | 0.01 | +0.01 | buy |
| CWM, LLC | 3,904 | 4,005 | +101 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 3,400 | 3,200 | -200 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,493 | 2,997 | -496 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,712 | +2,712 | 0.00 | 0.00 | +0.00 | buy |