| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Aberdeen Group plc | 4,092,062 | 7,966,498 | +3,874,436 | 0.02 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 7,143,948 | 7,395,740 | +251,792 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 12,795,000 | 6,789,738 | -6,005,262 | 4.41 | 1.46 | -2.95 | sell |
| VANGUARD GROUP INC | 4,669,815 | 4,941,542 | +271,727 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 4,030,619 | 3,990,169 | -40,450 | 0.61 | 0.39 | -0.22 | sell |
| Telemark Asset Management, LLC | 4,000,000 | 3,846,411 | -153,589 | 0.93 | 0.63 | -0.30 | sell |
| AMERIPRISE FINANCIAL INC | 2,773,646 | 3,793,574 | +1,019,928 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 4,067,559 | 3,135,192 | -932,367 | 0.01 | 0.00 | -0.00 | sell |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 635,545 | 2,568,359 | +1,932,814 | 0.16 | 0.39 | +0.23 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,992,404 | 2,026,006 | +33,602 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,540,754 | 1,603,510 | +62,756 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,164,846 | 1,135,190 | -29,656 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 522,383 | 809,520 | +287,137 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 756,158 | 740,558 | -15,600 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 310,486 | 737,485 | +426,999 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 724,255 | 718,109 | -6,146 | 0.00 | 0.00 | -0.00 | sell |
| Private Advisor Group, LLC | 561,413 | 654,581 | +93,168 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 645,274 | 645,296 | +22 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 584,367 | 641,926 | +57,559 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 173,805 | 628,291 | +454,486 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 233,953 | 566,547 | +332,594 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 537,833 | 537,833 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PERKINS CAPITAL MANAGEMENT INC | 307,700 | 529,500 | +221,800 | 0.66 | 0.69 | +0.02 | buy |
| Post Resch Tallon Group Inc. | 559,935 | 511,748 | -48,187 | 1.21 | 0.70 | -0.50 | sell |
| CITADEL ADVISORS LLC | 269,931 | 499,377 | +229,446 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 428,921 | +428,921 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 603,620 | 406,004 | -197,616 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 234,247 | 347,640 | +113,393 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 920,122 | 300,852 | -619,270 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 299,930 | +299,930 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 294,653 | +294,653 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,732 | 274,898 | +24,166 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 264,464 | 264,464 | 0 | 0.04 | 0.10 | +0.06 | hold |
| Stonepine Capital Management, LLC | 88,264 | 256,106 | +167,842 | 0.18 | 0.33 | +0.16 | buy |
| BARCLAYS PLC | 224,492 | 244,851 | +20,359 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 208,249 | 204,749 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 184,655 | +184,655 | 0.00 | 0.02 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 278,341 | 177,750 | -100,591 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 123,136 | 174,590 | +51,454 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 100,908 | 150,908 | +50,000 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 76,583 | 122,030 | +45,447 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 118,130 | 118,130 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 410,133 | 116,567 | -293,566 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 129,869 | 112,254 | -17,615 | 0.12 | 0.05 | -0.07 | sell |
| RHUMBLINE ADVISERS | 111,819 | 108,582 | -3,237 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 133,835 | 107,996 | -25,839 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 99,100 | 99,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 60,365 | 88,376 | +28,011 | 0.00 | 0.00 | -0.00 | buy |
| Jain Global LLC | 0 | 85,900 | +85,900 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 17,304 | 74,558 | +57,254 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 84,069 | 64,675 | -19,394 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 63,089 | +63,089 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 27,500 | 59,400 | +31,900 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 48,443 | 59,051 | +10,608 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 26,926 | 54,435 | +27,509 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,647 | 51,406 | +49,759 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 21,536 | 50,290 | +28,754 | 0.00 | 0.00 | -0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 50,000 | 50,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 44,269 | 44,269 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,742 | 41,398 | +2,656 | 0.00 | 0.00 | -0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 46,713 | 39,813 | -6,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 22,745 | 39,804 | +17,059 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 41,690 | 37,346 | -4,344 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 41,033 | 35,491 | -5,542 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 35,927 | 34,787 | -1,140 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 29,466 | 32,751 | +3,285 | 0.00 | 0.00 | -0.00 | buy |
| BLAIR WILLIAM & CO/IL | 35,293 | 30,390 | -4,903 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 30,389 | +30,389 | 0.00 | 0.01 | +0.01 | buy |
| Krilogy Financial LLC | 30,029 | 30,101 | +72 | 0.00 | 0.00 | -0.00 | buy |
| EVERGREEN CAPITAL MANAGEMENT LLC | 0 | 29,000 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 27,813 | +27,813 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 9,974 | 27,409 | +17,435 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 27,355 | +27,355 | 0.00 | 0.00 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 21,695 | 21,695 | 0 | 0.02 | 0.01 | -0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 16,608 | 20,668 | +4,060 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 17,215 | 20,214 | +2,999 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,441 | 19,441 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AIGEN INVESTMENT MANAGEMENT, LP | 15,830 | 17,629 | +1,799 | 0.01 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 67,717 | 17,095 | -50,622 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,888 | 16,888 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 13,102 | 16,870 | +3,768 | 0.00 | 0.00 | -0.00 | buy |
| Navalign, LLC | 0 | 15,340 | +15,340 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,843 | 14,843 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 15,823 | 14,718 | -1,105 | 0.00 | 0.00 | -0.00 | sell |
| FIDUCIARY TRUST CO | 13,620 | 13,620 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SEI INVESTMENTS CO | 10,536 | 10,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 10,072 | 10,081 | +9 | 0.00 | 0.00 | -0.00 | buy |
| GAMCO INVESTORS, INC. ET AL | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,500 | 8,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,428 | 8,428 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,934 | 5,485 | -449 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 56,040 | 5,417 | -50,623 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,490 | 4,389 | +899 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,780 | 2,803 | +23 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 973 | 2,604 | +1,631 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 1,800 | 1,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 4,293 | 1,794 | -2,499 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,942 | 1,775 | -167 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,587 | 1,587 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 1,198 | 1,471 | +273 | 0.00 | 0.00 | -0.00 | buy |