| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 4,650,409 | 4,522,096 | -128,313 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 3,155,180 | 3,336,409 | +181,229 | 0.16 | 0.17 | +0.01 | buy |
| STATE STREET CORP | 2,737,752 | 2,760,385 | +22,633 | 0.00 | 0.00 | -0.00 | buy |
| ARK Investment Management LLC | 2,136,403 | 2,227,556 | +91,153 | 0.27 | 0.30 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,191,000 | 2,191,000 | 0 | 0.53 | 0.45 | -0.08 | hold |
| BRAIDWELL LP | 1,585,220 | 2,173,146 | +587,926 | 0.96 | 1.26 | +0.30 | buy |
| Boston Partners | 901,929 | 1,883,534 | +981,605 | 0.02 | 0.03 | +0.02 | buy |
| GAGNON SECURITIES LLC | 1,774,890 | 1,761,874 | -13,016 | 6.81 | 7.06 | +0.25 | sell |
| Chevy Chase Trust Holdings, LLC | 1,081,342 | 1,504,075 | +422,733 | 0.06 | 0.08 | +0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,446,616 | 1,475,126 | +28,510 | 0.02 | 0.02 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 1,446,616 | 1,475,126 | +28,510 | 0.31 | 0.36 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,309,980 | 1,461,914 | +151,934 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,243,967 | 1,254,114 | +10,147 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,105,198 | 1,184,398 | +79,200 | 0.03 | 0.03 | -0.00 | buy |
| Ophir Asset Management Pty Ltd | 925,433 | 988,051 | +62,618 | 1.96 | 2.00 | +0.04 | buy |
| Blue Water Life Science Advisors, LP | 510,000 | 935,000 | +425,000 | 6.03 | 13.02 | +6.98 | buy |
| D. E. Shaw & Co., Inc. | 1,038,486 | 874,908 | -163,578 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 948,557 | 864,468 | -84,089 | 0.07 | 0.06 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 811,186 | 733,332 | -77,854 | 0.00 | 0.00 | -0.00 | sell |
| First Eagle Investment Management, LLC | 546,722 | 575,365 | +28,643 | 0.02 | 0.02 | -0.00 | buy |
| Russell Investments Group, Ltd. | 420,225 | 558,336 | +138,111 | 0.01 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 581,211 | 553,197 | -28,014 | 0.11 | 0.09 | -0.02 | sell |
| Gagnon Advisors, LLC | 532,892 | 532,892 | 0 | 6.37 | 6.81 | +0.43 | hold |
| Palo Alto Investors LP | 478,220 | 531,870 | +53,650 | 1.25 | 1.41 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,009 | 510,405 | -14,604 | 0.00 | 0.00 | -0.00 | sell |
| PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 375,000 | 500,000 | +125,000 | 14.60 | 11.80 | -2.80 | buy |
| ArrowMark Colorado Holdings LLC | 758,400 | 486,668 | -271,732 | 0.31 | 0.22 | -0.09 | sell |
| Invesco Ltd. | 115,503 | 484,938 | +369,435 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 324,825 | 470,665 | +145,840 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 487,050 | 458,301 | -28,749 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 449,886 | 454,508 | +4,622 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 541,522 | 425,349 | -116,173 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 345,308 | 417,744 | +72,436 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 333,898 | 390,294 | +56,396 | 0.00 | 0.00 | +0.00 | buy |
| Zweig-DiMenna Associates LLC | 679,000 | 390,255 | -288,745 | 0.91 | 0.95 | +0.04 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 665,065 | 370,183 | -294,882 | 0.03 | 0.01 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 303,035 | 349,225 | +46,190 | 0.00 | 0.00 | -0.00 | buy |
| Portolan Capital Management, LLC | 758,775 | 340,352 | -418,423 | 0.77 | 0.31 | -0.45 | sell |
| Meridiem Capital Partners LP | 0 | 316,950 | +316,950 | 0.00 | 0.36 | +0.36 | buy |
| JANUS HENDERSON GROUP PLC | 287,561 | 316,519 | +28,958 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 371,409 | 310,539 | -60,870 | 0.05 | 0.04 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 276,154 | 291,378 | +15,224 | 0.50 | 0.52 | +0.03 | buy |
| JANE STREET GROUP, LLC | 430,229 | 250,351 | -179,878 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 89,300 | 231,600 | +142,300 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 209,419 | 231,305 | +21,886 | 0.00 | 0.00 | +0.00 | buy |
| Bullseye Asset Management LLC | 235,485 | 220,485 | -15,000 | 2.39 | 2.22 | -0.17 | sell |
| Legal & General Group Plc | 230,482 | 209,763 | -20,719 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 78,839 | 197,925 | +119,086 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 174,748 | 173,013 | -1,735 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 169,910 | 170,347 | +437 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 233,171 | 166,474 | -66,697 | 0.01 | 0.01 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 161,991 | 156,483 | -5,508 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 169,868 | 145,680 | -24,188 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 139,439 | 139,439 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GLOBEFLEX CAPITAL L P | 79,795 | 119,252 | +39,457 | 0.23 | 0.31 | +0.08 | buy |
| LAZARD ASSET MANAGEMENT LLC | 116,302 | 116,751 | +449 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,190 | 115,785 | -9,405 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 120,354 | 115,207 | -5,147 | 0.03 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 87,580 | 114,350 | +26,770 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 83,493 | 101,747 | +18,254 | 0.11 | 0.13 | +0.03 | buy |
| Swiss National Bank | 99,700 | 99,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 125,004 | 98,317 | -26,687 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 120,031 | 94,159 | -25,872 | 0.00 | 0.00 | -0.00 | sell |
| Gotham Asset Management, LLC | 82,593 | 89,604 | +7,011 | 0.01 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 642,762 | 84,173 | -558,589 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 91,134 | 78,734 | -12,400 | 0.01 | 0.01 | -0.00 | sell |
| FORMULA GROWTH LTD | 100,668 | 78,478 | -22,190 | 0.73 | 0.61 | -0.12 | sell |
| ARS Investment Partners, LLC | 94,339 | 77,235 | -17,104 | 0.10 | 0.07 | -0.03 | sell |
| FRANKLIN RESOURCES INC | 103,703 | 69,444 | -34,259 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 78,625 | 68,925 | -9,700 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 69,198 | 65,500 | -3,698 | 0.00 | 0.00 | -0.00 | sell |
| Uniplan Investment Counsel, Inc. | 28,267 | 62,773 | +34,506 | 0.05 | 0.11 | +0.06 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61,516 | 62,673 | +1,157 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 55,495 | 60,245 | +4,750 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 52,549 | 51,907 | -642 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,545 | 50,646 | +3,101 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 45,143 | 49,873 | +4,730 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 39,218 | 47,001 | +7,783 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 46,460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,388 | 45,903 | -485 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 70,150 | 44,510 | -25,640 | 0.02 | 0.01 | -0.01 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 43,590 | 44,296 | +706 | 0.01 | 0.01 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 26,048 | 41,294 | +15,246 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 40,564 | 40,564 | 0 | 0.36 | 0.33 | -0.03 | hold |
| JPMORGAN CHASE & CO | 39,508 | 40,323 | +815 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 38,600 | 40,100 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 16,623 | 38,387 | +21,764 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 45,759 | 36,410 | -9,349 | 0.21 | 0.15 | -0.06 | sell |
| PROFUND ADVISORS LLC | 33,867 | 35,217 | +1,350 | 0.02 | 0.02 | +0.00 | buy |
| Creative Planning | 29,580 | 30,497 | +917 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 27,657 | 29,949 | +2,292 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 29,391 | 29,021 | -370 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 27,395 | 28,191 | +796 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 27,720 | +27,720 | 0.00 | 0.01 | +0.01 | buy |
| State of Wyoming | 8,253 | 23,537 | +15,284 | 0.02 | 0.05 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 21,566 | 21,566 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aquatic Capital Management LLC | 52,076 | 21,325 | -30,751 | 0.03 | 0.01 | -0.02 | sell |
| Allspring Global Investments Holdings, LLC | 19,091 | 21,242 | +2,151 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 10,468 | 19,092 | +8,624 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 17,689 | 18,701 | +1,012 | 0.00 | 0.00 | -0.00 | buy |