| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 4,522,096 | 4,814,709 | +292,613 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,760,385 | 2,468,858 | -291,527 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,191,000 | 1,997,618 | -193,382 | 0.45 | 0.59 | +0.15 | sell |
| ARK Investment Management LLC | 2,227,556 | 1,953,531 | -274,025 | 0.30 | 0.36 | +0.06 | sell |
| Boston Partners | 1,883,534 | 1,937,601 | +54,067 | 0.03 | 0.05 | +0.01 | buy |
| BAMCO INC /NY/ | 3,336,409 | 1,937,326 | -1,399,083 | 0.17 | 0.08 | -0.09 | sell |
| GAGNON SECURITIES LLC | 1,761,874 | 1,770,735 | +8,861 | 7.06 | 9.73 | +2.67 | buy |
| Chevy Chase Trust Holdings, LLC | 1,504,075 | 1,437,416 | -66,659 | 0.08 | 0.11 | +0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,254,114 | 1,328,037 | +73,923 | 0.00 | 0.00 | +0.00 | buy |
| Ophir Asset Management Pty Ltd | 988,051 | 1,264,809 | +276,758 | 2.00 | 2.96 | +0.97 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,184,398 | 1,242,959 | +58,561 | 0.03 | 0.05 | +0.02 | buy |
| BRAIDWELL LP | 2,173,146 | 1,220,602 | -952,544 | 1.26 | 1.29 | +0.03 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 1,475,126 | 1,191,630 | -283,496 | 0.02 | 0.02 | +0.00 | sell |
| Blue Water Life Science Advisors, LP | 935,000 | 1,190,000 | +255,000 | 13.02 | 21.36 | +8.35 | buy |
| Nikko Asset Management Americas, Inc. | 1,475,126 | 1,188,075 | -287,051 | 0.36 | 0.44 | +0.07 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,461,914 | 1,181,077 | -280,837 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 874,908 | 1,137,660 | +262,752 | 0.01 | 0.02 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 864,468 | 995,669 | +131,201 | 0.06 | 0.10 | +0.04 | buy |
| MORGAN STANLEY | 425,349 | 774,299 | +348,950 | 0.00 | 0.00 | +0.00 | buy |
| Divisadero Street Capital Management, LP | 0 | 700,938 | +700,938 | 0.00 | 0.47 | +0.47 | buy |
| GOLDMAN SACHS GROUP INC | 733,332 | 699,993 | -33,339 | 0.00 | 0.00 | +0.00 | sell |
| Portolan Capital Management, LLC | 340,352 | 684,805 | +344,453 | 0.31 | 0.73 | +0.42 | buy |
| First Eagle Investment Management, LLC | 575,365 | 598,497 | +23,132 | 0.02 | 0.03 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 553,197 | 575,971 | +22,774 | 0.09 | 0.13 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 470,665 | 571,808 | +101,143 | 0.00 | 0.00 | +0.00 | buy |
| Gagnon Advisors, LLC | 532,892 | 546,893 | +14,001 | 6.81 | 9.91 | +3.11 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 538,125 | +538,125 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 510,405 | 538,125 | +27,720 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 531,870 | 531,870 | 0 | 1.41 | 2.09 | +0.68 | hold |
| Russell Investments Group, Ltd. | 558,336 | 512,628 | -45,708 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 454,508 | 478,798 | +24,290 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 250,351 | 470,273 | +219,922 | 0.00 | 0.01 | +0.00 | buy |
| Meridiem Capital Partners LP | 316,950 | 451,493 | +134,543 | 0.36 | 0.59 | +0.23 | buy |
| Invesco Ltd. | 484,938 | 447,205 | -37,733 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 231,600 | 401,987 | +170,387 | 0.00 | 0.01 | +0.01 | buy |
| Zweig-DiMenna Associates LLC | 390,255 | 388,812 | -1,443 | 0.95 | 1.01 | +0.06 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 458,301 | 374,909 | -83,392 | 0.01 | 0.01 | +0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 372,111 | +372,111 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 369,837 | +369,837 | 0.00 | 0.01 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 486,668 | 338,549 | -148,119 | 0.22 | 0.40 | +0.18 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 310,539 | 296,200 | -14,339 | 0.04 | 0.06 | +0.02 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 370,183 | 268,207 | -101,976 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 231,305 | 253,314 | +22,009 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 349,225 | 244,375 | -104,850 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 417,744 | 224,829 | -192,915 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 214,342 | +214,342 | 0.00 | 0.06 | +0.06 | buy |
| Legal & General Group Plc | 209,763 | 211,967 | +2,204 | 0.00 | 0.00 | +0.00 | buy |
| Bullseye Asset Management LLC | 220,485 | 203,660 | -16,825 | 2.22 | 2.95 | +0.73 | sell |
| Parkman Healthcare Partners LLC | 291,378 | 202,417 | -88,961 | 0.52 | 0.59 | +0.07 | sell |
| HSBC HOLDINGS PLC | 38,387 | 196,250 | +157,863 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 13,453 | 186,391 | +172,938 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 170,347 | 171,014 | +667 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 173,013 | 170,146 | -2,867 | 0.01 | 0.02 | +0.00 | sell |
| Uniplan Investment Counsel, Inc. | 62,773 | 157,131 | +94,358 | 0.11 | 0.42 | +0.31 | buy |
| Nuveen, LLC | 390,294 | 152,509 | -237,785 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 156,483 | 150,478 | -6,005 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 145,680 | 149,987 | +4,307 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,477 | 141,623 | +125,146 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 114,350 | 128,992 | +14,642 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 166,474 | 126,962 | -39,512 | 0.01 | 0.01 | +0.00 | sell |
| GLOBEFLEX CAPITAL L P | 119,252 | 119,252 | 0 | 0.31 | 0.43 | +0.12 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 139,439 | 116,766 | -22,673 | 0.00 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,785 | 110,031 | -5,754 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 84,173 | 106,984 | +22,811 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 98,317 | 100,799 | +2,482 | 0.00 | 0.01 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 101,747 | 99,173 | -2,574 | 0.13 | 0.18 | +0.05 | sell |
| LAZARD ASSET MANAGEMENT LLC | 116,751 | 94,747 | -22,004 | 0.00 | 0.00 | +0.00 | sell |
| Kera Capital Partners, Inc. | 0 | 91,108 | +91,108 | 0.00 | 0.25 | +0.25 | buy |
| Swiss National Bank | 99,700 | 87,400 | -12,300 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 60,245 | 85,360 | +25,115 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 197,925 | 83,498 | -114,427 | 0.03 | 0.01 | -0.02 | sell |
| Palumbo Wealth Management LLC | 36,410 | 82,946 | +46,536 | 0.15 | 0.49 | +0.34 | buy |
| Jump Financial, LLC | 0 | 82,772 | +82,772 | 0.00 | 0.02 | +0.02 | buy |
| Regal Partners Ltd | 0 | 79,185 | +79,185 | 0.00 | 0.12 | +0.12 | buy |
| FORMULA GROWTH LTD | 78,478 | 78,026 | -452 | 0.61 | 0.78 | +0.17 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62,673 | 76,682 | +14,009 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 28,191 | 76,177 | +47,986 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 68,925 | 74,888 | +5,963 | 0.00 | 0.00 | +0.00 | buy |
| ARS Investment Partners, LLC | 77,235 | 74,235 | -3,000 | 0.07 | 0.09 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 73,809 | +73,809 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 89,604 | 73,579 | -16,025 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 69,444 | 68,788 | -656 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 65,500 | 68,206 | +2,706 | 0.00 | 0.00 | +0.00 | buy |
| Curated Wealth Partners LLC | 0 | 65,000 | +65,000 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 60,580 | +14,120 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,903 | 54,531 | +8,628 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 49,873 | 54,287 | +4,414 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 27,720 | 53,748 | +26,028 | 0.01 | 0.02 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 40,100 | 52,800 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 51,907 | 52,366 | +459 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 47,001 | 52,291 | +5,290 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,413 | 51,840 | +33,427 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 17,166 | 48,820 | +31,654 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 45,908 | +45,908 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 45,589 | +45,589 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 45,122 | +45,122 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 40,564 | 42,046 | +1,482 | 0.33 | 0.46 | +0.13 | buy |
| JPMORGAN CHASE & CO | 40,323 | 40,384 | +61 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 44,296 | 37,681 | -6,615 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 94,159 | 36,467 | -57,692 | 0.00 | 0.00 | -0.00 | sell |