| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,381,132 | 4,536,178 | +155,046 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 3,912,575 | 3,145,456 | -767,119 | 0.99 | 1.59 | +0.60 | sell |
| ARK Investment Management LLC | 5,702,351 | 2,988,597 | -2,713,754 | 0.79 | 0.85 | +0.07 | sell |
| STATE STREET CORP | 2,107,830 | 2,036,089 | -71,741 | 0.00 | 0.00 | +0.00 | sell |
| BAMCO INC /NY/ | 1,876,672 | 1,876,672 | 0 | 0.08 | 0.16 | +0.07 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 2,576,261 | 1,653,927 | -922,334 | 0.03 | 0.04 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 2,576,261 | 1,652,759 | -923,502 | 0.46 | 0.58 | +0.12 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,149,602 | 1,503,521 | +353,919 | 0.09 | 0.23 | +0.14 | buy |
| Invesco Ltd. | 90,739 | 1,463,690 | +1,372,951 | 0.00 | 0.01 | +0.01 | buy |
| GAGNON SECURITIES LLC | 2,174,167 | 1,437,722 | -736,445 | 7.60 | 8.90 | +1.30 | sell |
| D. E. Shaw & Co., Inc. | 1,727,890 | 1,360,227 | -367,663 | 0.04 | 0.06 | +0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,512,700 | 1,235,900 | -276,800 | 0.04 | 0.06 | +0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,195,583 | 1,227,724 | +32,141 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 183,613 | 905,381 | +721,768 | 0.03 | 0.24 | +0.22 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,178,040 | 814,716 | -363,324 | 0.08 | 0.10 | +0.02 | sell |
| MORGAN STANLEY | 630,902 | 761,598 | +130,696 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,283,912 | 750,857 | -533,055 | 0.01 | 0.01 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 390,671 | 696,893 | +306,222 | 0.03 | 0.11 | +0.08 | buy |
| FMR LLC | 69,320 | 625,550 | +556,230 | 0.00 | 0.00 | +0.00 | buy |
| Blue Water Life Science Advisors, LP | 510,000 | 604,000 | +94,000 | 7.70 | 16.59 | +8.88 | buy |
| First Eagle Investment Management, LLC | 968,552 | 594,314 | -374,238 | 0.03 | 0.04 | +0.00 | sell |
| Russell Investments Group, Ltd. | 120,544 | 535,373 | +414,829 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 458,330 | 504,770 | +46,440 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 485,933 | 499,480 | +13,547 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 421,904 | 452,001 | +30,097 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,140,909 | 450,739 | -1,690,170 | 0.03 | 0.01 | -0.02 | sell |
| Gagnon Advisors, LLC | 610,336 | 412,875 | -197,461 | 7.22 | 8.33 | +1.11 | sell |
| CITADEL ADVISORS LLC | 120,501 | 411,687 | +291,186 | 0.00 | 0.01 | +0.01 | buy |
| ROYCE & ASSOCIATES LP | 392,286 | 393,286 | +1,000 | 0.06 | 0.11 | +0.05 | buy |
| BANK OF MONTREAL /CAN/ | 584,589 | 392,819 | -191,770 | 0.00 | 0.01 | +0.00 | sell |
| Boston Partners | 24,289 | 375,138 | +350,849 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 55,711 | 368,430 | +312,719 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 348,219 | +348,219 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 250,581 | 340,326 | +89,745 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 336,648 | +336,648 | 0.00 | 0.16 | +0.16 | buy |
| AQR CAPITAL MANAGEMENT LLC | 180,059 | 329,794 | +149,735 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 105,980 | 312,524 | +206,544 | 0.00 | 0.02 | +0.02 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 250,400 | 294,500 | +44,100 | 0.24 | 0.47 | +0.23 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 610,055 | 269,184 | -340,871 | 0.03 | 0.03 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 141,800 | 258,300 | +116,500 | 0.00 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 256,580 | +256,580 | 0.00 | 0.03 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 190,953 | 241,208 | +50,255 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 182,765 | 216,630 | +33,865 | 0.06 | 0.13 | +0.07 | buy |
| Squarepoint Ops LLC | 0 | 214,751 | +214,751 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 208,513 | +208,513 | 0.00 | 0.08 | +0.08 | buy |
| Allspring Global Investments Holdings, LLC | 21,164 | 204,987 | +183,823 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 202,312 | 193,722 | -8,590 | 0.00 | 0.00 | +0.00 | sell |
| Bullseye Asset Management LLC | 184,820 | 184,820 | 0 | 1.41 | 2.66 | +1.26 | hold |
| PRUDENTIAL FINANCIAL INC | 130,185 | 177,477 | +47,292 | 0.00 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 164,801 | +164,801 | 0.00 | 0.47 | +0.47 | buy |
| JANE STREET GROUP, LLC | 153,670 | 152,896 | -774 | 0.00 | 0.01 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 143,249 | 150,093 | +6,844 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 139,880 | +139,880 | 0.00 | 0.18 | +0.18 | buy |
| Bank of New York Mellon Corp | 193,994 | 139,768 | -54,226 | 0.00 | 0.00 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 0 | 136,830 | +136,830 | 0.00 | 0.33 | +0.33 | buy |
| UBS Group AG | 113,370 | 127,779 | +14,409 | 0.00 | 0.00 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 123,402 | +123,402 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 112,984 | +112,984 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 107,890 | +107,890 | 0.00 | 0.50 | +0.50 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 123,082 | 107,543 | -15,539 | 0.00 | 0.01 | +0.00 | sell |
| BARCLAYS PLC | 44,023 | 98,505 | +54,482 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 121,996 | 98,136 | -23,860 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 0 | 96,800 | +96,800 | 0.00 | 0.00 | +0.00 | buy |
| ARS Investment Partners, LLC | 81,435 | 95,885 | +14,450 | 0.12 | 0.27 | +0.15 | buy |
| GLOBEFLEX CAPITAL L P | 5,443 | 89,148 | +83,705 | 0.01 | 0.27 | +0.26 | buy |
| AMERICAN CENTURY COMPANIES INC | 108,366 | 86,690 | -21,676 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 70,142 | 83,550 | +13,408 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 81,331 | 81,331 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 84,159 | 79,750 | -4,409 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 23,830 | 75,382 | +51,552 | 0.01 | 0.05 | +0.04 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 111,936 | 70,551 | -41,385 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 89,434 | 68,239 | -21,195 | 0.01 | 0.01 | +0.00 | sell |
| Assenagon Asset Management S.A. | 166,305 | 65,787 | -100,518 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 44,236 | 59,474 | +15,238 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 53,514 | +53,514 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 68,050 | 51,260 | -16,790 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 87,667 | 50,755 | -36,912 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 89,351 | 50,385 | -38,966 | 0.01 | 0.01 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,622 | 49,420 | +46,798 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,613 | 46,974 | +43,361 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 75,584 | 45,387 | -30,197 | 0.43 | 0.42 | -0.01 | sell |
| Main Management ETF Advisors, LLC | 0 | 45,008 | +45,008 | 0.00 | 0.07 | +0.07 | buy |
| SEI INVESTMENTS CO | 0 | 41,456 | +41,456 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 32,375 | 41,170 | +8,795 | 0.00 | 0.00 | +0.00 | buy |
| Curi Capital, LLC | 40,547 | 40,547 | 0 | 0.02 | 0.03 | +0.01 | hold |
| HRT FINANCIAL LP | 65,299 | 40,198 | -25,101 | 0.01 | 0.01 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 41,817 | 40,131 | -1,686 | 0.00 | 0.01 | +0.00 | sell |
| ROYAL BANK OF CANADA | 31,932 | 39,778 | +7,846 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 55,145 | 39,445 | -15,700 | 0.72 | 0.97 | +0.24 | sell |
| LPL Financial LLC | 35,666 | 37,584 | +1,918 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 29,874 | 36,345 | +6,471 | 0.08 | 0.14 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 0 | 36,181 | +36,181 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 37,003 | 35,914 | -1,089 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 32,658 | +32,658 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 18,039 | 31,923 | +13,884 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 30,871 | +30,871 | 0.00 | 0.01 | +0.01 | buy |
| Corton Capital Inc. | 29,550 | 29,758 | +208 | 0.24 | 0.45 | +0.21 | buy |
| Baird Financial Group, Inc. | 0 | 29,723 | +29,723 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 30,344 | 28,900 | -1,444 | 0.00 | 0.01 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 28,580 | +28,580 | 0.00 | 0.02 | +0.02 | buy |