| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 4,657,919 | 4,766,917 | +108,998 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,910,571 | 3,749,707 | -1,160,864 | 0.00 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 2,435,657 | 3,155,180 | +719,523 | 0.13 | 0.12 | -0.01 | buy |
| STATE STREET CORP | 2,180,145 | 2,566,449 | +386,304 | 0.00 | 0.00 | -0.00 | buy |
| Ophir Asset Management Pty Ltd | 1,892,994 | 2,197,947 | +304,953 | 3.87 | 3.95 | +0.08 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 2,191,000 | +2,191,000 | 0.00 | 0.49 | +0.49 | buy |
| BRAIDWELL LP | 0 | 2,182,781 | +2,182,781 | 0.00 | 0.94 | +0.94 | buy |
| ARK Investment Management LLC | 2,100,157 | 2,170,625 | +70,468 | 0.30 | 0.19 | -0.11 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,236,928 | 1,740,064 | +503,136 | 0.02 | 0.01 | -0.00 | buy |
| Nikko Asset Management Americas, Inc. | 1,235,591 | 1,740,064 | +504,473 | 0.24 | 0.24 | +0.00 | buy |
| GAGNON SECURITIES LLC | 1,548,912 | 1,729,425 | +180,513 | 6.15 | 5.04 | -1.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,323,497 | 1,297,425 | -26,072 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 962,785 | 1,216,524 | +253,739 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,155,698 | 1,155,598 | -100 | 0.03 | 0.02 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 1,082,308 | 1,069,809 | -12,499 | 0.07 | 0.05 | -0.03 | sell |
| ArrowMark Colorado Holdings LLC | 719,207 | 966,916 | +247,709 | 0.25 | 0.26 | +0.01 | buy |
| Portolan Capital Management, LLC | 629,977 | 933,532 | +303,555 | 0.77 | 0.73 | -0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,233,759 | 929,023 | -304,736 | 0.11 | 0.05 | -0.06 | sell |
| GOLDMAN SACHS GROUP INC | 1,130,575 | 862,283 | -268,292 | 0.00 | 0.00 | -0.00 | sell |
| Chevy Chase Trust Holdings, LLC | 512,549 | 743,751 | +231,202 | 0.03 | 0.03 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,092,401 | 704,080 | -388,321 | 0.08 | 0.04 | -0.04 | sell |
| CITADEL ADVISORS LLC | 790,667 | 623,813 | -166,854 | 0.01 | 0.01 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 615,374 | 594,491 | -20,883 | 0.01 | 0.01 | -0.00 | sell |
| Zweig-DiMenna Associates LLC | 226,600 | 575,000 | +348,400 | 0.45 | 0.65 | +0.20 | buy |
| Bellevue Group AG | 752,371 | 572,956 | -179,415 | 0.32 | 0.17 | -0.15 | sell |
| Kent Lake PR LLC | 0 | 550,000 | +550,000 | 0.00 | 4.09 | +4.09 | buy |
| Gagnon Advisors, LLC | 454,163 | 529,414 | +75,251 | 5.96 | 4.75 | -1.21 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 526,028 | 525,291 | -737 | 0.00 | 0.00 | -0.00 | sell |
| Blue Water Life Science Advisors, LP | 724,014 | 510,000 | -214,014 | 11.20 | 6.77 | -4.43 | sell |
| Prosight Management, LP | 302,808 | 504,030 | +201,222 | 1.44 | 1.76 | +0.32 | buy |
| NORTHERN TRUST CORP | 493,369 | 492,742 | -627 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 410,502 | 486,299 | +75,797 | 0.00 | 0.00 | -0.00 | buy |
| First Eagle Investment Management, LLC | 379,023 | 475,146 | +96,123 | 0.01 | 0.01 | -0.00 | buy |
| MACQUARIE GROUP LTD | 513,767 | 462,952 | -50,815 | 0.01 | 0.01 | -0.00 | sell |
| PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 219,403 | 425,000 | +205,597 | 6.81 | 11.02 | +4.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 68,492 | 413,689 | +345,197 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 778,604 | 404,394 | -374,210 | 0.16 | 0.06 | -0.10 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 381,937 | 371,409 | -10,528 | 0.05 | 0.04 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 349,984 | 318,588 | -31,396 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 0 | 316,204 | +316,204 | 0.00 | 0.85 | +0.85 | buy |
| Russell Investments Group, Ltd. | 258,869 | 252,761 | -6,108 | 0.01 | 0.00 | -0.00 | sell |
| Bullseye Asset Management LLC | 182,485 | 225,485 | +43,000 | 1.78 | 1.72 | -0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,428 | 193,436 | +176,008 | 0.00 | 0.00 | +0.00 | buy |
| FORMULA GROWTH LTD | 192,293 | 192,293 | 0 | 1.42 | 0.99 | -0.42 | hold |
| FIRST TRUST ADVISORS LP | 93,256 | 188,445 | +95,189 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 259,763 | 187,913 | -71,850 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 186,985 | 186,895 | -90 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 165,558 | 184,617 | +19,059 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 110,264 | 168,721 | +58,457 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 186,949 | 168,622 | -18,327 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 180,619 | 166,783 | -13,836 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 117,526 | 160,002 | +42,476 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 4,211 | 155,616 | +151,405 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 151,099 | 154,771 | +3,672 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 55,392 | 154,162 | +98,770 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 274,688 | 140,919 | -133,769 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 41,609 | 130,893 | +89,284 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 122,486 | 127,574 | +5,088 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 102,740 | 126,335 | +23,595 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 126,215 | 111,459 | -14,756 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 2,543,419 | 109,745 | -2,433,674 | 0.01 | 0.00 | -0.01 | sell |
| ARS Investment Partners, LLC | 95,885 | 106,055 | +10,170 | 0.14 | 0.10 | -0.03 | buy |
| Swiss National Bank | 100,600 | 102,500 | +1,900 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.10 | 0.06 | -0.04 | hold |
| FRANKLIN RESOURCES INC | 74,144 | 99,929 | +25,785 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 47,012 | 98,824 | +51,812 | 0.01 | 0.02 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 98,470 | +98,470 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 93,015 | +93,015 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 71,369 | 92,498 | +21,129 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 2,004 | 89,742 | +87,738 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 84,687 | 81,910 | -2,777 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,244 | 78,152 | +12,908 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 71,592 | +71,592 | 0.00 | 0.00 | +0.00 | buy |
| GLOBEFLEX CAPITAL L P | 85,208 | 71,003 | -14,205 | 0.14 | 0.16 | +0.02 | sell |
| JUPITER ASSET MANAGEMENT LTD | 198,384 | 69,715 | -128,669 | 0.03 | 0.01 | -0.02 | sell |
| JPMORGAN CHASE & CO | 68,602 | 64,659 | -3,943 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 68,734 | 64,652 | -4,082 | 0.00 | 0.00 | -0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 32,382 | 58,262 | +25,880 | 0.06 | 0.06 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 47,781 | 54,148 | +6,367 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 155,197 | 52,445 | -102,752 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 32,870 | 51,532 | +18,662 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,867 | 46,870 | +3 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,519 | 46,460 | -59 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 141,683 | 44,531 | -97,152 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 166,259 | 44,084 | -122,175 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 21,390 | 42,310 | +20,920 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 40,564 | 40,564 | 0 | 0.48 | 0.32 | -0.16 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 42,041 | 40,122 | -1,919 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34,543 | 38,507 | +3,964 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 36,984 | +36,984 | 0.00 | 0.17 | +0.17 | buy |
| WELLS FARGO & COMPANY/MN | 30,393 | 33,584 | +3,191 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 33,107 | +33,107 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 32,071 | 32,071 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Boston Partners | 21,491 | 31,355 | +9,864 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 30,670 | +30,670 | 0.00 | 0.04 | +0.04 | buy |
| Allianz Asset Management GmbH | 68,826 | 30,117 | -38,709 | 0.00 | 0.00 | -0.00 | sell |
| NEEDHAM INVESTMENT MANAGEMENT LLC | 15,000 | 30,000 | +15,000 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 210,200 | 28,100 | -182,100 | 0.01 | 0.00 | -0.01 | sell |
| Creative Planning | 0 | 27,987 | +27,987 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 35,077 | 22,324 | -12,753 | 0.00 | 0.00 | -0.00 | sell |