| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 4,766,917 | 4,650,409 | -116,508 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 3,749,707 | 3,428,252 | -321,455 | 0.00 | 0.00 | +0.00 | sell |
| BAMCO INC /NY/ | 3,155,180 | 3,155,180 | 0 | 0.12 | 0.16 | +0.04 | hold |
| STATE STREET CORP | 2,566,449 | 2,737,752 | +171,303 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,191,000 | 2,191,000 | 0 | 0.49 | 0.53 | +0.04 | hold |
| ARK Investment Management LLC | 2,170,625 | 2,136,403 | -34,222 | 0.19 | 0.27 | +0.08 | sell |
| GAGNON SECURITIES LLC | 1,729,425 | 1,774,890 | +45,465 | 5.04 | 6.81 | +1.76 | buy |
| BRAIDWELL LP | 2,182,781 | 1,585,220 | -597,561 | 0.94 | 0.96 | +0.01 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 1,740,064 | 1,446,616 | -293,448 | 0.01 | 0.02 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,740,064 | 1,446,616 | -293,448 | 0.24 | 0.31 | +0.07 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,216,524 | 1,309,980 | +93,456 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,297,425 | 1,243,967 | -53,458 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,155,598 | 1,105,198 | -50,400 | 0.02 | 0.03 | +0.01 | sell |
| Chevy Chase Trust Holdings, LLC | 743,751 | 1,081,342 | +337,591 | 0.03 | 0.06 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 594,491 | 1,038,486 | +443,995 | 0.01 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 704,080 | 948,557 | +244,477 | 0.04 | 0.07 | +0.03 | buy |
| Ophir Asset Management Pty Ltd | 2,197,947 | 925,433 | -1,272,514 | 3.95 | 1.96 | -1.99 | sell |
| Boston Partners | 31,355 | 901,929 | +870,574 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 862,283 | 811,186 | -51,097 | 0.00 | 0.00 | +0.00 | sell |
| Portolan Capital Management, LLC | 933,532 | 758,775 | -174,757 | 0.73 | 0.77 | +0.03 | sell |
| ArrowMark Colorado Holdings LLC | 966,916 | 758,400 | -208,516 | 0.26 | 0.31 | +0.05 | sell |
| Zweig-DiMenna Associates LLC | 575,000 | 679,000 | +104,000 | 0.65 | 0.91 | +0.26 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,069,809 | 665,065 | -404,744 | 0.05 | 0.03 | -0.02 | sell |
| CITADEL ADVISORS LLC | 623,813 | 642,762 | +18,949 | 0.01 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 404,394 | 581,211 | +176,817 | 0.06 | 0.11 | +0.05 | buy |
| First Eagle Investment Management, LLC | 475,146 | 546,722 | +71,576 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 486,299 | 541,522 | +55,223 | 0.00 | 0.00 | +0.00 | buy |
| Gagnon Advisors, LLC | 529,414 | 532,892 | +3,478 | 4.75 | 6.37 | +1.62 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,291 | 525,009 | -282 | 0.00 | 0.00 | +0.00 | sell |
| Blue Water Life Science Advisors, LP | 510,000 | 510,000 | 0 | 6.77 | 6.03 | -0.74 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 193,436 | 487,050 | +293,614 | 0.00 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 316,204 | 478,220 | +162,016 | 0.85 | 1.25 | +0.40 | buy |
| NORTHERN TRUST CORP | 492,742 | 449,886 | -42,856 | 0.00 | 0.00 | +0.00 | sell |
| Bellevue Group AG | 572,956 | 431,070 | -141,886 | 0.17 | 0.15 | -0.02 | sell |
| JANE STREET GROUP, LLC | 93,015 | 430,229 | +337,214 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 252,761 | 420,225 | +167,464 | 0.00 | 0.01 | +0.00 | buy |
| PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 425,000 | 375,000 | -50,000 | 11.02 | 14.60 | +3.58 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 371,409 | 371,409 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Aberdeen Group plc | 0 | 345,308 | +345,308 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 168,622 | 333,898 | +165,276 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 318,588 | 324,825 | +6,237 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 187,913 | 303,035 | +115,122 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 21,900 | 287,561 | +265,661 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 276,154 | +276,154 | 0.00 | 0.50 | +0.50 | buy |
| Prosight Management, LP | 504,030 | 250,000 | -254,030 | 1.76 | 0.97 | -0.79 | sell |
| Bullseye Asset Management LLC | 225,485 | 235,485 | +10,000 | 1.72 | 2.39 | +0.67 | buy |
| Man Group plc | 154,162 | 233,171 | +79,009 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 160,002 | 230,482 | +70,480 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 155,616 | 209,419 | +53,803 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 929,023 | 174,748 | -754,275 | 0.05 | 0.01 | -0.04 | sell |
| Bank of New York Mellon Corp | 154,771 | 169,910 | +15,139 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 184,617 | 169,868 | -14,749 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 186,895 | 164,413 | -22,482 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 166,783 | 161,991 | -4,792 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 18,712 | 139,439 | +120,727 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,919 | 125,190 | -15,729 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 168,721 | 125,004 | -43,717 | 0.01 | 0.01 | -0.00 | sell |
| Engineers Gate Manager LP | 98,824 | 120,354 | +21,530 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 111,459 | 120,031 | +8,572 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 126,335 | 116,302 | -10,033 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 109,745 | 115,503 | +5,758 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 99,929 | 103,703 | +3,774 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 28,100 | 102,300 | +74,200 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 33,107 | 100,956 | +67,849 | 0.01 | 0.02 | +0.02 | buy |
| FORMULA GROWTH LTD | 192,293 | 100,668 | -91,625 | 0.99 | 0.73 | -0.26 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 40,122 | 99,870 | +59,748 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 413,689 | 99,735 | -313,954 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 102,500 | 99,700 | -2,800 | 0.00 | 0.00 | +0.00 | sell |
| ARS Investment Partners, LLC | 106,055 | 94,339 | -11,716 | 0.10 | 0.10 | +0.00 | sell |
| Rafferty Asset Management, LLC | 92,498 | 91,134 | -1,364 | 0.00 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 89,300 | +89,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 71,592 | 87,580 | +15,988 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 58,262 | 83,493 | +25,231 | 0.06 | 0.11 | +0.05 | buy |
| Gotham Asset Management, LLC | 0 | 82,593 | +82,593 | 0.00 | 0.01 | +0.01 | buy |
| GLOBEFLEX CAPITAL L P | 71,003 | 79,795 | +8,792 | 0.16 | 0.23 | +0.07 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 78,839 | +78,839 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 54,148 | 78,625 | +24,477 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 42,310 | 70,150 | +27,840 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 81,910 | 69,198 | -12,712 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 64,652 | 61,516 | -3,136 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 33,584 | 57,129 | +23,545 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 44,084 | 55,495 | +11,411 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 52,445 | 52,549 | +104 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 89,742 | 52,076 | -37,666 | 0.02 | 0.03 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,152 | 47,545 | -30,607 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 46,460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,870 | 46,388 | -482 | 0.00 | 0.00 | +0.00 | sell |
| Palumbo Wealth Management LLC | 36,984 | 45,759 | +8,775 | 0.17 | 0.21 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 127,574 | 45,143 | -82,431 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 51,532 | 43,590 | -7,942 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 40,607 | +40,607 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 40,564 | 40,564 | 0 | 0.32 | 0.36 | +0.04 | hold |
| JPMORGAN CHASE & CO | 64,659 | 39,508 | -25,151 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,507 | 39,218 | +711 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 38,600 | +38,600 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 44,531 | 38,123 | -6,408 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 20,079 | 33,867 | +13,788 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 31,240 | +31,240 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 27,987 | 29,580 | +1,593 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 32,071 | 29,391 | -2,680 | 0.00 | 0.00 | +0.00 | sell |